DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ich and zld

DIOPT Version :9

Sequence 1:	NP_001262393.1	Gene:	ich / 41069	FlyBaseID:	FBgn0286204	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001285466.1	Gene:	zld / 32994	FlyBaseID:	FBgn0259789	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	844	Identity:	155/844 - (18%)
Similarity:	230/844 - (27%)	Gaps:	397/844 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PPFTGYTGHLSINGISG---HHYHAIAQRLPDESNNNYMQSAYHPQNQSNPTSTTQSNG------ 138
            ||..|..|.|.:..:.|   ..|.|...  |.:...:::.   |.|.|:|..:...:||
  Fly   653 PPDYGGGGGLGVGAMGGAAMSQYSASPS--PTQQQQHHLN---HHQQQANGYANGTANGYGYMQQ 712

  Fly   139 ------------GSNSNSNNSNE---------------HNIVSSSTCLPESVLSGSGGGGGGNDA 176
                        .||:||||..:               ||          |||:|...|..|..|
  Fly   713 QVQSTTNASPQHASNNNSNNQQQQQQQQQHHQQQMPQHHN----------SVLNGHPNGLAGPSA 767

  Fly   177 ---------------------------------------------CLADVKLFADSQLDSKLYSV 196
                                                         ....|.:.::...||.....
  Fly   768 PHNNNTTQMPSSQMRGLLNETTTTPPPTTTTRAPQITTTATTTTTAATTVAIKSEQMEDSNHTHT 832

  Fly   197 ADSCVMNGSGSGSAANGNGSGPSIAT-------LTPIDQVADSLH-------------------- 234
            ......|.|.|...::.:.|..|:||       |...:|..|.||
  Fly   833 HTHTHPNHSHSQDRSHSSSSSSSMATEEAEEQELRDQEQADDHLHQHQQASQQYLLSARHYHSST 897

  Fly   235 ----------------NSGVRIYKDLTEYVDMN-------------------------------- 251
                            ||...||:...:..|.:
  Fly   898 PNTLSSSNTNPSTPSSNSPHTIYRQEQQGTDFSRTTPPPQPLPPMGMLPPMAMDYNMLALDMPMP 962

  Fly   252 ---------------SIDDIAAIIGSAIADTTVP-----------------------NQLDKDDN 278
                           |...:|..|.:::.||..|                       :|..:.|:
  Fly   963 MPTLMHSNMLQCSSTSTTPLATTITTSMPDTMQPPQQQLVHHYQAVLHPLHQQLGEQHQRQEADH 1027

  Fly   279 NDTRDSWMDLDAWIDGNCIQQESAKVLVSQQDSL------------------------GDFILPH 319
            :..:.....||.       ||:..:.|: ..|||                        ...:||.
  Fly  1028 HQQQRELHQLDQ-------QQQQQQALI-LADSLPHSSSSPTSSSPPPTMPMPLTTITAPQLLPL 1084

  Fly   320 SPLPMHASSSTLQSLLSHGYMPLL------QNRLQ-------------NGPPNGNSSGGGGGANQ 365
            .|.|.|.:|:.......|  ||::      ..:||             :||.....:.|||.:||
  Fly  1085 QPPPPHITSTMPMPPTMH--MPIMPPPPQCYQQLQPLDPTMSYHTIIGSGPEAHTGTAGGGYSNQ 1147

  Fly   366 GAGIKGD-----------PQAPTSTSYCNELAAATSSSCSPPGSVVSTTDNPNGLMINPRYLSNP 419
            .....|.           |.||.|                 |.||.:......|.:       .|
  Fly  1148 ITTSDGQILQLMPTSLFAPYAPLS-----------------PYSVAAQRSPQEGDL-------PP 1188

  Fly   420 TNNQATG-NLHQQGG-YSMQASGLSLKDNGLCSPDLLGNYPHTTTAS--TTGSEMRTGA------ 474
            .:...|. :.||||| ...|...|::    |.:|     |..|.::|  |...||....
  Fly  1189 VHTLTTALHAHQQGGQQEAQTPTLTV----LSTP-----YSPTVSSSRATPALEMDMATLMQHHQ 1244

  Fly   475 -------PKAKRSRSQKKSNQQQQQQQQQQQQQGD----------------GGGQPTTPQM---- 512
                   ....:...|.:.:|||...|||||...|                |...|:|.:.
  Fly  1245 DYEMEQYQMQHQQLDQMQQHQQQLDHQQQQQILADQTQTMAQQPLAKKRRGGNATPSTTKRRRNS 1309

  Fly   513 --------SAISPSG---------------------------------------FSASDL-SGLL 529
                    |...|||                                       |.:.|: :..|
  Fly  1310 SVGSTSPHSTTLPSGRIKCLECDKEFTKNCYLTQHNKSFHSGEYPFRCQKCGKRFQSEDVYTTHL 1374

  Fly   530 GK----EKPVHRCSICNRGFLNKSNIKVHLRT-HTGEKPFRCDVCAKAFRQKAHLLKHQQIHKR 588
            |:    :|| |:|.:|.:.|.:|::::.|:.. |||.|...||:|.|.|.:|.||.||.:.|.|
  Fly  1375 GRHRTQDKP-HKCELCPKQFHHKTDLRRHVEAIHTGLKQHMCDICEKGFCRKDHLRKHLETHNR 1437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ich	NP_001262393.1	C2H2 Zn finger	538..558	CDD:275368	5/20 (25%)
		zf-H2C2_2	550..575	CDD:316026	10/25 (40%)
		C2H2 Zn finger	566..586	CDD:275368	10/19 (53%)
zld	NP_001285466.1	zf-C2H2_jaz	552..577	CDD:288983
		LIM	1328..1389	CDD:259829	8/61 (13%)
		C2H2 Zn finger	1328..1349	CDD:275368	0/20 (0%)
		C2H2 Zn finger	1357..1377	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1386..1407	CDD:275368	5/20 (25%)
		zf-H2C2_2	1398..1422	CDD:290200	9/23 (39%)
		zf-C2H2	1413..1435	CDD:278523	10/21 (48%)
		C2H2 Zn finger	1415..1435	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100