DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11964 and ctnnbl1

DIOPT Version :9

Sequence 1:	NP_649847.1	Gene:	CG11964 / 41068	FlyBaseID:	FBgn0037644	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_957160.1	Gene:	ctnnbl1 / 393840	ZFINID:	ZDB-GENE-040426-1850	Length:	563	Species:	Danio rerio

Alignment Length:	587	Identity:	318/587 - (54%)
Similarity:	424/587 - (72%)	Gaps:	30/587 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDIGELLAFKPEQTPKRPHDDEDDEFDLASSHGKRGGVDEKTKRMRRIADAKESAHYVKQSGGAT 65
            ||:||||.::|::..|||.|  .|..:.:.|..|..|.|.....:|...:.:|          .|
Zfish     1 MDVGELLNYQPDRGAKRPRD--GDSHEESRSKQKAAGRDAGRVLLRSEDNTEE----------PT 53

  Fly    66 GGSGTSAFEFDPELTEEERLNILKYVENEEADGDVLDEQSLKKLILVFEKRNLKNQEMRIKFADS 130
            .|.|....|   .|.::         :.|:.:.:::||.::||:||.||||:.||||:||||.|:
Zfish    54 AGDGDKVLE---RLMDQ---------DGEDPEAELVDESTVKKMILTFEKRSYKNQELRIKFPDN 106

  Fly   131 PEKFMDSEVELHTVIQELKGVATVPDLYPILVDLHGLHSLLELLAHQNTDIAVAVVDLLQEVTDV 195
            |||||::|::|:.:|||:..:||:|:||.:||:|:.:.|||.||:|.||||::||||||||:||:
Zfish   107 PEKFMEAELDLNDIIQEMHVIATIPELYHLLVELNAVQSLLGLLSHDNTDISIAVVDLLQELTDI 171

  Fly   196 DILGESQEGAESLIEALRKEQICALLVQNLERLNEQVKEEADGVHNTLAIVENLTEIDSEFVKEA 260
            |.|.||:||||.||:||.:.|:.||:|||:|||:|.||||||||:||||::||:.|.......||
Zfish   172 DTLHESEEGAEVLIDALLEGQVVALMVQNMERLDETVKEEADGVYNTLAVIENMAEFRPGLCTEA 236

  Fly   261 AEQGLLAWLLKRLRGKSPFDPNKLYCSEILSILIQTENENRLLLGSLDGVDVLLQQLAVYKRHDP 325
            |:|||:.|||||::.|.|||.|||||||||:||:|..::.|.|||.:||:|||||||:|:|||:|
Zfish   237 AQQGLMQWLLKRIKAKMPFDANKLYCSEILAILLQNNDKTRELLGEMDGIDVLLQQLSVFKRHNP 301

  Fly   326 ASNEEQEYMQNLFNCLCSALMARENRDRFLSGEGLQLMNLMLREKKMSRNGSLKVLDHAMAGQDG 390
            ::.||||.|:|||:.|||.||...||||||.||||||||||||||||||..:|||||:.|.|.:|
Zfish   302 STAEEQEMMENLFDALCSCLMLPANRDRFLRGEGLQLMNLMLREKKMSRVSALKVLDYGMIGPEG 366

  Fly   391 RDNCNKFVEILGLRTIFPLFMKTPKRNKQRLISADEHEEHVTSVIASMLRNCKGTHRQRMLAKFT 455
            .|||:|||:||||||||||||||||:.|:..||..:|||||.|:|||||||.||..|.|:|:|||
Zfish   367 SDNCHKFVDILGLRTIFPLFMKTPKKMKKVGISDKQHEEHVCSIIASMLRNLKGQQRSRLLSKFT 431

  Fly   456 ENDHEKVDRLLELHLKYLAKVEAIDKEIDQQAKDPT----IDEDEEAENNYIKRLTGGLFTLQRI 516
            |||.||||||:|||.|||..|:..||.|:.:..|..    |.:|...:..|::||..|||.||.:
Zfish   432 ENDCEKVDRLMELHFKYLEAVQLADKRIEGEKHDMVRRGEILDDAMDDEFYLRRLDAGLFVLQLL 496

  Fly   517 DYILLEVSATG-DTVKQRVLQILNLRGASMKTIRSIMREYAGNLGDGDT-DWREQEQNHILSLVD 579
            .||::|:.|.| ..::|||.|||||||.|:|.:|.||||||.|:|||.: :::|.||..|:.|::
Zfish   497 CYIMVEICAAGVPQLQQRVHQILNLRGGSVKVVRHIMREYAENIGDGKSEEFKESEQKRIMELLE 561

  Fly   580 RF 581
            .|
Zfish   562 NF 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11964	NP_649847.1	CTNNBL	87..183	CDD:285433	48/95 (51%)
CG11964	NP_649847.1	ARM	<155..251	CDD:237987	62/95 (65%)
ctnnbl1	NP_957160.1	CTNNBL	61..159	CDD:285433	50/109 (46%)
ctnnbl1	NP_957160.1	ARM	<125..220	CDD:237987	60/94 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596373
Domainoid	1	1.000	475	1.000	Domainoid score	I414
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12003
Inparanoid	1	1.050	602	1.000	Inparanoid score	I911
OMA	1	1.010	-	-		QHG54792
OrthoDB	1	1.010	-	-		D387271at33208
OrthoFinder	1	1.000	-	-		FOG0005506
OrthoInspector	1	1.000	-	-		oto41757
orthoMCL	1	0.900	-	-		OOG6_102971
Panther	1	1.100	-	-	LDO	PTHR14978
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1951
SonicParanoid	1	1.000	-	-		X3926
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940