DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ScsbetaA and SUCLA2

DIOPT Version :9

Sequence 1:	NP_001163558.1	Gene:	ScsbetaA / 41067	FlyBaseID:	FBgn0037643	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_003841.1	Gene:	SUCLA2 / 8803	HGNCID:	11448	Length:	463	Species:	Homo sapiens

Alignment Length:	437	Identity:	251/437 - (57%)
Similarity:	330/437 - (75%)	Gaps:	9/437 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AIKKILGLA--------PIAVQQLRNLNVQEHVSYSLLNEAKIPTPRFAVAKNGKEANDIATKLK 76
            |..::||.:        .:..||.|||::.|::|..||.||.:..|:..|||:..||..||.||.
Human    27 AAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLG 91

  Fly    77 TDNLVLKAQVLAGGRGKGTFKNGLKGGVRVVYDPQTAEELSSKMIDQLLVTKQTGAAGRICKKVM 141
            :.::|:||||||||||||||::||||||::|:.|:.|:.:||:||.:.|.|||||..||||.:|:
Human    92 SKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVL 156

  Fly   142 VAERKFPRREFYFAVMMERAFNGPVLIASKEGGVDIEEVAASSPDAILYEPIDIGTGLTSEQAEK 206
            |.|||:||||:|||:.|||:|.|||||.|..|||:||:|||.||:||:.|||||..|:..|||.:
Human   157 VCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQ 221

  Fly   207 IVKKVGLGGDGEDTHVQMLLNLYDLFVKKDALLVEINPYAEDAMSGCFFALDAKLRFDDNAEFRQ 271
            :.:|:|...:..::..:.::.||.||:|.||.::||||..||: .|....:|||:.||.|:.:||
Human   222 LAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDS-DGAVLCMDAKINFDSNSAYRQ 285

  Fly   272 KELFALRDWTQEDPKEVEAAKYNLNYIALDGTIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGG 336
            |::|.|:||||||.::.:|||.|||||.|||.|||:||||||||||||||||:||.|||||||||
Human   286 KKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGG 350

  Fly   337 GATAEAVKAAFKIITSDPKVLCILVNIFGGIMRCDVIAEGIISATKDLNLNMPVVVRLQGTKVKE 401
            |||...|..|||:||||.|||.||||||||||||||||:||:.|.|||.:.:|||||||||:|.:
Human   351 GATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDD 415

  Fly   402 ARELIRTSGLKILARDDLDKAADLAVHLAQIVKLAREMKMDVNFEIP 448
            |:.||..|||||||.||||:||.:.|.|::||.||::..:||.|::|
Human   416 AKALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLP 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ScsbetaA	NP_001163558.1	PLN00124	28..427	CDD:177736	238/406 (59%)
		ATP-grasp_4	39..247	CDD:302634	110/207 (53%)
		Ligase_CoA	307..427	CDD:278948	89/119 (75%)
SUCLA2	NP_003841.1	sucC	55..445	CDD:234813	235/390 (60%)
SUCLA2	NP_003841.1	Substrate binding, shared with subunit alpha. /evidence=ECO:0000255\|HAMAP-Rule:MF_03220	380..382		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143765
Domainoid	1	1.000	222	1.000	Domainoid score	I2610
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2856
Inparanoid	1	1.050	494	1.000	Inparanoid score	I1413
Isobase	1	0.950	-	0	Normalized mean entropy	S442
OMA	1	1.010	-	-		QHG60702
OrthoDB	1	1.010	-	-		D342254at33208
OrthoFinder	1	1.000	-	-		FOG0001148
OrthoInspector	1	1.000	-	-		oto90224
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11815
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2690
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.960