DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ScsbetaA and sucla2

DIOPT Version :9

Sequence 1:	NP_001163558.1	Gene:	ScsbetaA / 41067	FlyBaseID:	FBgn0037643	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_998191.1	Gene:	sucla2 / 406299	ZFINID:	ZDB-GENE-040426-1963	Length:	466	Species:	Danio rerio

Alignment Length:	447	Identity:	258/447 - (57%)
Similarity:	333/447 - (74%)	Gaps:	16/447 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TVRPAAIKKILG------------LAP-IAVQQLRNLNVQEHVSYSLLNEAKIPTPRFAVAKNGK 66
            ||..||  |:||            .:| :::||.|.|::.|::|..||.||.|..|...||....
Zfish    22 TVSSAA--KVLGGTSGLFGHHGNQPSPMLSLQQQRKLSLHEYMSIGLLKEAGISVPAGMVASTPD 84

  Fly    67 EANDIATKLKTDNLVLKAQVLAGGRGKGTFKNGLKGGVRVVYDPQTAEELSSKMIDQLLVTKQTG 131
            ||...|.::.:.:||:||||||||||||||:.|||||||:||.|:.|.::|||||.:.|.|||||
Zfish    85 EAYTAAKQIGSKDLVIKAQVLAGGRGKGTFEGGLKGGVRIVYSPEEARDISSKMIGKKLFTKQTG 149

  Fly   132 AAGRICKKVMVAERKFPRREFYFAVMMERAFNGPVLIASKEGGVDIEEVAASSPDAILYEPIDIG 196
            .|||||.:|.|.||::||||:|||:.|||::.|||||.|.:|||:||:|||.:||||:.|||||.
Zfish   150 EAGRICNQVFVCERRYPRREYYFAITMERSYQGPVLIGSSQGGVNIEDVAAENPDAIVKEPIDIV 214

  Fly   197 TGLTSEQAEKIVKKVGLGGDGEDTHVQMLLNLYDLFVKKDALLVEINPYAEDAMSGCFFALDAKL 261
            .|:..:||.|:.:|:|......:...:.:|.|||:|:|.||.:|||||..||: ||....:|||:
Zfish   215 EGIKMDQAIKVAEKMGFPPALINEAAENMLKLYDVFIKYDASMVEINPMVEDS-SGIVMCMDAKI 278

  Fly   262 RFDDNAEFRQKELFALRDWTQEDPKEVEAAKYNLNYIALDGTIGCMVNGAGLAMATMDIIKLYGG 326
            .||.||.:|||::|.:|||:|||.::.:|||.:||||.|||||||:||||||||||||||||:||
Zfish   279 NFDSNAAYRQKKVFDMRDWSQEDARDRQAAKADLNYIGLDGTIGCLVNGAGLAMATMDIIKLHGG 343

  Fly   327 EPANFLDVGGGATAEAVKAAFKIITSDPKVLCILVNIFGGIMRCDVIAEGIISATKDLNLNMPVV 391
            .|||||||||||||:.|..|||:||||.||..||||||||||||||||:|||.|..||:|.:|:|
Zfish   344 TPANFLDVGGGATAQQVTEAFKLITSDKKVQAILVNIFGGIMRCDVIAQGIIMAVTDLDLKIPIV 408

  Fly   392 VRLQGTKVKEARELIRTSGLKILARDDLDKAADLAVHLAQIVKLAREMKMDVNFEIP 448
            ||||||:|.:|:.||..|.|||||.||||:||.:.|.|::||.||:|.::||.|::|
Zfish   409 VRLQGTRVDDAKALIAASPLKILACDDLDEAAKMVVKLSEIVSLAKEAQVDVKFQLP 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ScsbetaA	NP_001163558.1	PLN00124	28..427	CDD:177736	240/399 (60%)
		ATP-grasp_4	39..247	CDD:302634	112/207 (54%)
		Ligase_CoA	307..427	CDD:278948	88/119 (74%)
sucla2	NP_998191.1	sucC	58..448	CDD:234813	237/390 (61%)
		ATP-grasp_2	58..265	CDD:285620	112/206 (54%)
		Ligase_CoA	324..444	CDD:278948	88/119 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576708
Domainoid	1	1.000	222	1.000	Domainoid score	I2529
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2856
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1363
OMA	1	1.010	-	-		QHG60702
OrthoDB	1	1.010	-	-		D342254at33208
OrthoFinder	1	1.000	-	-		FOG0001148
OrthoInspector	1	1.000	-	-		oto39302
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11815
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1412
SonicParanoid	1	1.000	-	-		X2690
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.900