DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ScsbetaA and Sucla2

DIOPT Version :9

Sequence 1:	NP_001163558.1	Gene:	ScsbetaA / 41067	FlyBaseID:	FBgn0037643	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001101857.2	Gene:	Sucla2 / 361071	RGDID:	1309397	Length:	465	Species:	Rattus norvegicus

Alignment Length:	416	Identity:	246/416 - (59%)
Similarity:	324/416 - (77%)	Gaps:	1/416 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QQLRNLNVQEHVSYSLLNEAKIPTPRFAVAKNGKEANDIATKLKTDNLVLKAQVLAGGRGKGTFK 97
            ||.|:|::.|::|..||.||.:..|:..|||:..||..||.||.:.::|:||||||||||||||.
  Rat    50 QQQRSLSLHEYLSMELLQEAGVSVPKGFVAKSSDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFT 114

  Fly    98 NGLKGGVRVVYDPQTAEELSSKMIDQLLVTKQTGAAGRICKKVMVAERKFPRREFYFAVMMERAF 162
            :||||||::|:.|:.|:.:||:||.|.|:||||||.||||.:|:|.|||:||||:|||:.|||:|
  Rat   115 SGLKGGVKIVFSPEEAKAVSSQMIGQKLITKQTGAKGRICNQVLVCERKYPRREYYFAITMERSF 179

  Fly   163 NGPVLIASKEGGVDIEEVAASSPDAILYEPIDIGTGLTSEQAEKIVKKVGLGGDGEDTHVQMLLN 227
            .|||||.|.:|||:||:|||.:|:||:.||:||..|:..|||..:.||:|...:..|:..:.::.
  Rat   180 QGPVLIGSSQGGVNIEDVAAENPEAIVKEPVDIIEGVKKEQAVTLAKKMGFPSNIVDSAAENMIK 244

  Fly   228 LYDLFVKKDALLVEINPYAEDAMSGCFFALDAKLRFDDNAEFRQKELFALRDWTQEDPKEVEAAK 292
            ||:||:|.||.:|||||..||| .|....:|||:.||.|:.:|||::|||:||:|||.::.:||.
  Rat   245 LYNLFLKYDATMVEINPMVEDA-DGKVLCMDAKINFDSNSAYRQKKIFALQDWSQEDERDKDAAD 308

  Fly   293 YNLNYIALDGTIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGATAEAVKAAFKIITSDPKVL 357
            .::|||.|||.|||:||||||||||||||||:||.||||||||||||...|..|||:||||.:|.
  Rat   309 ADINYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKRVQ 373

  Fly   358 CILVNIFGGIMRCDVIAEGIISATKDLNLNMPVVVRLQGTKVKEARELIRTSGLKILARDDLDKA 422
            .|||||||||||||:||:||:.|.|||.:.:|||||||||:|.:|:.||..|||||||.||||:|
  Rat   374 AILVNIFGGIMRCDIIAQGIVMAVKDLEIRIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEA 438

  Fly   423 ADLAVHLAQIVKLAREMKMDVNFEIP 448
            |.:.|.|::||.||:|..:||.|::|
  Rat   439 AKMVVKLSEIVTLAKEAHVDVKFQLP 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ScsbetaA	NP_001163558.1	PLN00124	28..427	CDD:177736	235/393 (60%)
		ATP-grasp_4	39..247	CDD:302634	113/207 (55%)
		Ligase_CoA	307..427	CDD:278948	86/119 (72%)
Sucla2	NP_001101857.2	sucC	57..447	CDD:234813	233/390 (60%)
		ATP-grasp_2	57..264	CDD:285620	113/206 (55%)
		Ligase_CoA	323..443	CDD:278948	86/119 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337532
Domainoid	1	1.000	230	1.000	Domainoid score	I2368
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2856
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1349
OMA	1	1.010	-	-		QHG60702
OrthoDB	1	1.010	-	-		D342254at33208
OrthoFinder	1	1.000	-	-		FOG0001148
OrthoInspector	1	1.000	-	-		oto97342
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11815
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2690
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870