DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ScsbetaA and Acly

DIOPT Version :9

Sequence 1:	NP_001163558.1	Gene:	ScsbetaA / 41067	FlyBaseID:	FBgn0037643	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_058683.2	Gene:	Acly / 24159	RGDID:	2018	Length:	1101	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	110/484 - (22%)
Similarity:	170/484 - (35%)	Gaps:	129/484 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LKTDNLVLKAQVLAGGRGKGTFKNGLKG------GVRVVYDPQTAEELSSKMIDQLLVTKQTGAA 133
            |.:.:||:|...|...||    |.||.|      ||:....|:...|.:            .|.|
  Rat    50 LLSQSLVVKPDQLIKRRG----KLGLVGVNLSLDGVKSWLKPRLGHEAT------------VGKA 98

  Fly   134 GRICKKVMVAERKFPR---REFYFAVMMERAFNGPVLIASKEGGVDIEEVAASSPDAILYEPIDI 195
            ....|..:: |...|.   .|||..:...|  .|..::...|||||:.:|...:...:    :.:
  Rat    99 KGFLKNFLI-EPFVPHSQAEEFYVCIYATR--EGDYVLFHHEGGVDVGDVDTKAQKLL----VGV 156

  Fly   196 GTGLTSEQAEKIVKKVGLGGDGED------THVQMLLNLY-DLFVKKDALLVEINP--YAEDAMS 251
            ...|.:|.    :|:..|....||      :.:..|.|.| ||:.    ..:||||  ..:|.:
  Rat   157 DEKLNAED----IKRHLLVHAPEDKKEILASFISGLFNFYEDLYF----TYLEINPLVVTKDGV- 212

  Fly   252 GCFFALDAKLRFDDNAEFRQK---------ELFALRDWTQE----DPKEVEAAKYNLNYIALDGT 303
               :.||...:.|..|::..|         ..|....:.:|    |......|...|..:...|.
  Rat   213 ---YILDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGR 274

  Fly   304 IGCMVNGAGLAMATMDIIKLYGG--EPANFLDVGGG----ATAEAVKAAFKIIT----SDPKVLC 358
            |..||.|.|.::...|.|...||  |.||:.:..|.    .|.:..|....::|    .|.|:|
  Rat   275 IWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKIL- 338

  Fly   359 ILVNIFGGIMR--CDVIA--EGIISATKDL-----NLNMPVVVRLQGTKVKEA----RELIRTSG 410
                |.||.:.  .:|.|  :||:.|.:|.     ...:.:.||..|...:|.    .|:.:|:|
  Rat   339 ----IIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTG 399

  Fly   411 LKI----------------LARDDLDKAADLAVHLAQIVKLA---------------REMKMDVN 444
            :.|                |....:......|.|.|..:..|               .|.:.|
  Rat   400 IPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRAD-- 462

  Fly   445 FEIPDAQKGKGDCKKDQ-KQPDSKGGKKS 472
             |:..|:|.|....:|. ..|.|..||.:
  Rat   463 -EVAPAKKAKPAMPQDSVPSPRSLQGKSA 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ScsbetaA	NP_001163558.1	PLN00124	28..427	CDD:177736	95/421 (23%)
		ATP-grasp_4	39..247	CDD:302634	46/189 (24%)
		Ligase_CoA	307..427	CDD:278948	36/158 (23%)
Acly	NP_058683.2	Citrate_bind	1..419	CDD:421882	94/408 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..486		9/45 (20%)
		PLN02522	489..1094	CDD:178137	0/2 (0%)
		CoA-binding. /evidence=ECO:0000255	779..789
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810