DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ScsbetaA and suca-1

DIOPT Version :9

Sequence 1:	NP_001163558.1	Gene:	ScsbetaA / 41067	FlyBaseID:	FBgn0037643	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_509821.1	Gene:	suca-1 / 181280	WormBaseID:	WBGene00009812	Length:	435	Species:	Caenorhabditis elegans

Alignment Length:	444	Identity:	237/444 - (53%)
Similarity:	309/444 - (69%)	Gaps:	13/444 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LARTGGPLIETVRPAAIKKILGLAPIAVQQLRNLNVQEHVSYSLLNEAKIPTPRFAVAKNGKEAN 69
            :.|...||:.|.:..       :||.|    |.|.:.||....:|...:|..|.|.||::.:.|.
Worm     2 IGRISQPLLNTSQKF-------MAPAA----RTLMLHEHHGMKILQNYEIKVPPFGVAQDAETAF 55

  Fly    70 DIATKLKTDNLVLKAQVLAGGRGKGTFKNGLKGGVRVVYDPQTAEELSSKMIDQLLVTKQTGAAG 134
            ..|.::...:.|:||||||||||||.|.:||:|||::|:.|...::.:..||...|:||||...|
Worm    56 SEAKRIGGKDYVVKAQVLAGGRGKGRFSSGLQGGVQIVFTPDEVKQKAGMMIGANLITKQTDHRG 120

  Fly   135 RICKKVMVAERKFPRREFYFAVMMERAFNGPVLIASKEGGVDIEEVAASSPDAILYEPIDIGTGL 199
            :.|::|||.:|.|.|||:||::.::|..|||::|||.:|||:||||||::||||:..|||:..|:
Worm   121 KKCEEVMVCKRLFTRREYYFSITLDRNTNGPIVIASSQGGVNIEEVAATNPDAIVKMPIDVNVGI 185

  Fly   200 TSEQAEKIVKKVGLGGDGEDTHVQMLLNLYDLFVKKDALLVEINPYAEDAMSGCFFALDAKLRFD 264
            |.|.|.:|..|:|...|.|....:::..||.:|...||.||||||.||| ::|..:.:|.||..|
Worm   186 TKELAHEIAVKMGFSKDCEQQASEIIEKLYQMFKGSDATLVEINPMAED-VNGDVYCMDCKLLLD 249

  Fly   265 DNAEFRQKELFALRDWTQEDPKEVEAAKYNLNYIALDGTIGCMVNGAGLAMATMDIIKLYGGEPA 329
            .||||||.:||.|:|..|||..|:.||..|||||.||||||||||||||||||||||||:|||||
Worm   250 SNAEFRQAKLFDLKDKKQEDELEIRAAAANLNYIRLDGTIGCMVNGAGLAMATMDIIKLHGGEPA 314

  Fly   330 NFLDVGGGATAEAVKAAFKIITSD-PKVLCILVNIFGGIMRCDVIAEGIISATKDLNLNMPVVVR 393
            ||||||||||.|.|..||||||:| .||..||||||||||||||||:|||.|.::|:|.:|:|||
Worm   315 NFLDVGGGATVEQVTEAFKIITADKDKVSAILVNIFGGIMRCDVIAQGIIQAARELDLKIPIVVR 379

  Fly   394 LQGTKVKEARELIRTSGLKILARDDLDKAADLAVHLAQIVKLAREMKMDVNFEI 447
            ||||||::|:.||.||.|:||..|:||:||.:.|.|:.||.|||...:||.||:
Worm   380 LQGTKVEDAKALIATSQLRILPCDNLDEAAKMVVKLSNIVDLARATNVDVKFEL 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ScsbetaA	NP_001163558.1	PLN00124	28..427	CDD:177736	222/399 (56%)
		ATP-grasp_4	39..247	CDD:302634	93/207 (45%)
		Ligase_CoA	307..427	CDD:278948	88/120 (73%)
suca-1	NP_509821.1	ATP-grasp_2	25..233	CDD:285620	93/207 (45%)
		sucC	26..417	CDD:234813	219/391 (56%)
		Ligase_CoA	292..413	CDD:278948	88/120 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157875
Domainoid	1	1.000	187	1.000	Domainoid score	I1983
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2856
Inparanoid	1	1.050	437	1.000	Inparanoid score	I944
Isobase	1	0.950	-	0	Normalized mean entropy	S442
OMA	1	1.010	-	-		QHG60702
OrthoDB	1	1.010	-	-		D342254at33208
OrthoFinder	1	1.000	-	-		FOG0001148
OrthoInspector	1	1.000	-	-		oto18635
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11815
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1412
SonicParanoid	1	1.000	-	-		X2690
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890