DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ScsbetaA and acly-1

DIOPT Version :9

Sequence 1:	NP_001163558.1	Gene:	ScsbetaA / 41067	FlyBaseID:	FBgn0037643	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_508280.1	Gene:	acly-1 / 180485	WormBaseID:	WBGene00016995	Length:	1106	Species:	Caenorhabditis elegans

Alignment Length:	427	Identity:	101/427 - (23%)
Similarity:	162/427 - (37%)	Gaps:	86/427 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IPTPRFAVAKNGKEANDIATK---LKTDNL-VLKAQVLAGGRGK-GTFKNGLKGGVRVVYDPQTA 113
            :..|.....|.|:..::||.|   |..||. |:|...|...||| |..|.|         .||..
Worm    25 LSAPHAFHVKAGENFDEIANKYEWLARDNKGVIKPDQLIKRRGKLGLVKIG---------TPQEL 80

  Fly   114 EELSSKMIDQLLVTKQTGAAGRICKKVMVAE---RKFPRREFYFAVMMERAFNGPVLIASKEGGV 175
            :....|..|..:...||  .||:  ...:.|   ....:.|.|.|:..||..:  |::..::|||
Worm    81 KAWFEKTGDSYVRVGQT--EGRL--HTFIVEPFCAHTEKDEMYIAIYSERFRD--VIMFYEQGGV 139

  Fly   176 DIEEVAASSPDAILYEPIDIGTGLTSEQAEKIVKKVGLGGDGEDTHVQMLLNLYDLFVKKDALLV 240
            ||.:|...:....:  |:.:.....:...|::...:|...| .|...:.::.||..:.......:
Worm   140 DIGDVEEKARTVSV--PVQLNENAMTPSDEELTTLLGPLKD-SDIVRRFVVELYKAYKDLHFTYL 201

  Fly   241 EINPYAEDAMSGCFFALDAKLRFDDNAEFRQKELFAL------------------RDWTQEDP-- 285
            ||||:.  .::.....||...|.|:.|.|...:.:..                  ||.|.|:.
Worm   202 EINPFV--LLNNQIHVLDLAARLDETANFLCADKWKSRLTPYGGPNHVEFPAPFGRDLTSEEQYI 264

  Fly   286 KEVEA---AKYNLNYIALDGTIGCMVNGAGLAMATMDIIKLYGG--EPANFLDVGG----GATAE 341
            .|::|   |...|..:...|.:..||.|.|.::...|.:...||  |.||:.:..|    ..|.|
Worm   265 SEMDAKTGASLKLTILNRKGRVWTMVAGGGASVVFTDTVCDLGGASELANYGEYSGDPSESQTYE 329

  Fly   342 AVKAAFKIITS-----DPKVLCI---------LVNIFGGIMRCDVIAEGIISATKDLNLNMPVVV 392
            ..|....::|.     |.|||.|         :...||||:|.   .|..:|..|:..:.  :.|
Worm   330 YAKTLLSVMTEGTPRPDGKVLIIGGSIANFTNVAKTFGGIVRA---FETFVSKLKEHKVT--IFV 389

  Fly   393 RLQGTKVKEARELIRTSGLKILARDDLDKAADLAVHL 429
            |..|...:|....|:.:..|:          :|.:|:
Worm   390 RRGGPNYQEGLRRIKDAATKL----------ELPIHV 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ScsbetaA	NP_001163558.1	PLN00124	28..427	CDD:177736	100/423 (24%)
		ATP-grasp_4	39..247	CDD:302634	50/200 (25%)
		Ligase_CoA	307..427	CDD:278948	35/139 (25%)
acly-1	NP_508280.1	PLN02235	1..431	CDD:177879	101/427 (24%)
		ATP-grasp_4	8..208	CDD:302634	50/202 (25%)
		Citrate_bind	258..432	CDD:292732	43/174 (25%)
		PLN02522	492..1097	CDD:178137
		CoA_binding	496..600	CDD:280747
		Ligase_CoA	660..785	CDD:278948
		CCL_ACL-C	856..1096	CDD:99854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810