DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and SLC9A3R2

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_016879383.1	Gene:	SLC9A3R2 / 9351	HGNCID:	11076	Length:	372	Species:	Homo sapiens

Alignment Length:	311	Identity:	72/311 - (23%)
Similarity:	112/311 - (36%)	Gaps:	57/311 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 DPYLPGGASY----SSQNLYVQPPTRTSNGPNIN----GNGLNDEKSNLTPRGRSRGPIMDGVSL 579
            :|....|.|:    .|.:....||.....||...    |..|...:|:..| ||:........::
Human    96 EPSQGSGLSHHPAPQSDSAPTSPPIPGEPGPQREVDKWGGSLGRPESSGHP-GRTPATCCHCAAV 159

  Fly   580 QQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQK--EG 642
            .......||.   :.|...|||.||.|....|..:|               ..||....:|  :|
Human   160 MARSGSATPP---ARAPGAPPRSPPQRLDVSGPLRE---------------LRPRLCHLRKGPQG 206

  Fly   643 SVGIRL-TGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRID 706
             .|..| :..:..|.::.:|.|||||:..||...|::::||..::.|:...|.|..:.:.:|...
Human   207 -YGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEAR 270

  Fly   707 LIVQYCKEEYDEVVTNQRGDSFHIK------THFHCDNPSKGEMAFKAGDVFRVIDTLHNGVVGS 765
            |:|  ...|.||          |.|      |..|.:.|....:.......     .|:.|...|
Human   271 LLV--VDPETDE----------HFKRLRVTPTEEHVEGPLPSPVTNGTSPA-----QLNGGSACS 318

  Fly   766 WQVLKIGRGHQEMQRG--VIPNKSRAEELATA-QFNATKKEMNANESRGNF 813
            .:....|......:.|  :.|..:.|:|.|.| :.|....:|:.|..|..|
Human   319 SRSDLPGSDKDTEESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIF 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492	23/79 (29%)
		SH3_ZO	729..790	CDD:212793	11/68 (16%)
		GuKc	831..1007	CDD:214504
		ZU5	2263..2351	CDD:279170
SLC9A3R2	XP_016879383.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910