DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and DLG5

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens

Alignment Length:	1133	Identity:	259/1133 - (22%)
Similarity:	431/1133 - (38%)	Gaps:	305/1133 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KPSTRRRSFKTK-------PPKSN--VYNPLVRYRPTAYVRNGIIGGAEGPGSSGVYQIADRVYT 57
            ||..|:..|...       |||.:  :..|...:.|....|.|.:...:.|..|...:...|:.|
Human   966 KPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLET 1030

  Fly    58 TSKMFLRDGYMYPRQPGQT--------MDPRFPLELHEFPQQFGATGLQLVSAPKVHIAGEYLAS 114
            :|:   .:..:....|..:        :||..|  :|..|.:          ..:|.||..|...
Human  1031 SSE---SEATLVGSSPSTSPPSALPPDVDPGEP--MHASPPR----------KARVRIASSYYPE 1080

  Fly   115 EQ-------QQQQQQQQQQHQQVQEQQQLGRR-KAAAAAEINLANQV---YWLGKQKT------- 161
            ..       .::...:....|:|.|..|..|| |:|.:....||..|   .:|.:||.
Human  1081 GDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGEL 1145

  Fly   162 -------------RSRSRSN--------SVGN--RSIT-----------------SCMGGGGGGG 186
                         .|...||        |||.  ||:|                 |...|.....
Human  1146 SPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSP 1210

  Fly   187 EKERERGGDRDRPYIRNVDDLLQALGKRDGGD-------NNSNLLETASTHSSSQRRRFKKGDRT 244
            ...|:.|.....|.:::...|...|..|...|       :.||.|.:::...||...:||.
Human  1211 PAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKA---- 1271

  Fly   245 TWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVS 309
                ..:.:...|.|            |....|....:||......|.:..|
Human  1272 ----ERIKIPSTPRY------------PRSVVGSERGSVSHSECSTPPQSPL------------- 1307

  Fly   310 LENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPI 374
              |::..::....:.|.:|:.     |:.:||               :|:|........|
Human  1308 --NIDTLSSCSQSQTSASTLP-----RIAVNP---------------ASLGERRKDRPYV----- 1345

  Fly   375 TSLSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQ 439
               .:|..:.   ||..|  :|:.:::..|.|    |.:...::.|..|:.:|         .|:
Human  1346 ---EEPRHVK---VQKGS--EPLGISIVSGEK----GGIYVSKVTVGSIAHQA---------GLE 1389

  Fly   440 EGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIY 504
            .||.:...:..|      |:.|      .:::..|::.:.....|.::|               |
Human  1390 YGDQLLEFNGIN------LRSA------TEQQARLIIGQQCDTITILAQ---------------Y 1427

  Fly   505 ATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRS 569
            ..|..|:|..|.|:::|:    |.|...:.|                 |:|      ..||...|
Human  1428 NPHVHQLSSHSRSSSHLD----PAGTHSTLQ-----------------GSG------TTTPEHPS 1465

  Fly   570 RGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPR 634
               ::|.:..|                ||.|..||.:.||...|.:          ..:::.|||
Human  1466 ---VIDPLMEQ----------------DEGPSTPPAKQSSSRIAGD----------ANKKTLEPR 1501

  Fly   635 FISFQK-EGSVGIRLTGGNEAGIFVTAVQPGSPA-SLQGLMPGDKILKVNDMDMNGVTREEAVLF 697
            .:..:| :..:|:.|.|||..|:||..|:..||| ...||:|||.||:...:|:...|.||..:.
Human  1502 VVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVE 1566

  Fly   698 LLSLQDRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGV 762
            :|..:|.:.|.|||..||:.: .....||||:|:..:......:.|::||..|:..|.|||..|.
Human  1567 MLKPRDGVRLKVQYRPEEFTK-AKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTLPQGT 1630

  Fly   763 VGSWQVLKIGRGHQEMQRGVIPNK-------SRAEELATAQ-FNATKKEMNANESRGNFFRRRRS 819
            .|||...::....|::|||.||:|       ||...::..: .|:..|.::| .:|.:||||:
Human  1631 FGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSA-AARRSFFRRK-- 1692

  Fly   820 THRRSKSLSRENWD----DVVFSDSISKFP-----AYERVVLRHPGFVRPVVLFGPVSDLARERL 875
             |:..:|.|::..|    |...||||..|.     ||:||.......:|||::.||:.|:.:|.|
Human  1693 -HKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEML 1756

  Fly   876 AKDFPDKF-STPLQDDDKSAAT----------------SGKCRIVRLSNIRDVMDRGKHALLDIT 923
            ..:.|.|| ..||:....|...                ||...:..:::|:::.::.:|.||||.
Human  1757 VNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIA 1821

  Fly   924 PNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGL---PKAAHKSSKKLLEQCQKLERVWSHIFST 985
            |:|::||::...||:|||:...|...||:.|..:   .|...:.||:..|..||||:.:|..|:.
Human  1822 PHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTG 1886

  Fly   986 QIALSDEESWYRKLRDSIDLQQSGAVWM 1013
            .|......|...::...::.:|:..:|:
Human  1887 VIQGGALSSICTQILAMVNQEQNKVLWI 1914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	11/84 (13%)
		PDZ_signaling	396..477	CDD:238492	14/80 (18%)
		PDZ_signaling	633..710	CDD:238492	29/78 (37%)
		SH3_ZO	729..790	CDD:212793	22/67 (33%)
		GuKc	831..1007	CDD:214504	58/204 (28%)
		ZU5	2263..2351	CDD:279170
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142
		Takusan	130..212	CDD:282652
		TPR_MLP1_2	231..353	CDD:285204
		COG1340	295..587	CDD:224259
		FliJ	310..449	CDD:304890
		BAR	417..601	CDD:299863
		PDZ_signaling	620..707	CDD:238492
		DegQ	<702..771	CDD:223343
		PDZ_signaling	722..790	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122		34/170 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306		7/54 (13%)
		PDZ	1347..1429	CDD:214570	21/126 (17%)
		dbPDZ_assoc	1427..1499	CDD:293216	25/127 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493		22/114 (19%)
		PDZ	1499..1582	CDD:214570	33/82 (40%)
		SH3_DLG5	1597..1659	CDD:212794	20/61 (33%)
		GuKc	1732..1908	CDD:214504	47/175 (27%)
		Guanylate_kin	1740..1907	CDD:279019	47/166 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910