DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and CASK

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_001354650.1	Gene:	CASK / 8573	HGNCID:	1497	Length:	926	Species:	Homo sapiens

Alignment Length:	860	Identity:	162/860 - (18%)
Similarity:	288/860 - (33%)	Gaps:	277/860 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 PINAAG---AVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSLNSSLVQNASSGQPIKVTLT 402
            |:...|   |:|      |...||:|.|..|.          |:.:...:|:....|:|:.|.
Human   157 PVKLGGFGVAIQ------LGESGLVAGGRVGT----------PHFMAPEVVKREPYGKPVDVW-- 203

  Fly   403 KGGKKDDYGVVL-----GC--------RLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGD 454
                  ..||:|     ||        |||...|..|.:
Human   204 ------GCGVILFILLSGCLPFYGTKERLFEGIIKGKYK-------------------------- 236

  Fly   455 TMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQ-VSGCSSSN 518
             |:.::...|.:..|:.:..:::.|...:..|.:. ||:....:.....|..|.|: |......|
Human   237 -MNPRQWSHISESAKDLVRRMLMLDPAERITVYEA-LNHPWLKERDRYAYKIHLPETVEQLRKFN 299

  Fly   519 --NNLEDPYLPGGASYSSQNLYVQPPTRT---SNGPNING------------------NGLND-- 558
              ..|:...|...:|:...:.|..||...   |..|..:|                  :.|.|
Human   300 ARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCS 364

  Fly   559 -----------------------EKSNLTPRGRSRGPIMDGV-----------------SLQQLD 583
                                   :|.|.....:.|.|..|.|                 ..::|.
Human   365 EKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELK 429

  Fly   584 RPVTPTR-----------------GRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSA 631
            |.:|...                 ..:..:..||..|...|.|..:|..|.        :.....
Human   430 RILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDM--------DMENVT 486

  Fly   632 EPRFISFQK--EGSVGIRLTGGNEAGIFVTAVQPGSPASLQG-LMPGDKILKVNDMDMNGVTREE 693
            ..|.:.|||  :..:||.|.........|..:..|.....|| |..||:|.::|.:.:...|.|:
Human   487 RVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQ 551

  Fly   694 AVLFLLSLQDRI--DLIVQY------CKEEYDEV---------------------VTNQRGDSFH 729
            ....|..::..|  .::..|      |:.:....                     .|..:|...:
Human   552 LQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIY 616

  Fly   730 IKTHFHCDNPSKGEM--------AFKAGDVFRVID-TLHNGVVGSWQVLKIGRGHQEMQRGVIPN 785
            ::..|..| |:|.::        .|:.||:.::|. ..||...|..:..|.|..      |:||:
Human   617 VRAQFEYD-PAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTA------GLIPS 674

  Fly   786 KSRAE-ELATAQFNATKKEMNANESRGNFFRRRRSTHRRSKSLSREN--WD--DVVFSDSISKFP 845
            ....| .:|......||:|..|:   ..:|.:::..: :.|.|::.|  :|  |:|..:.:.|.|
Human   675 PELQEWRVACIAMEKTKQEQQAS---CTWFGKKKKQY-KDKYLAKHNAVFDQLDLVTYEEVVKLP 735

  Fly   846 AYERVVLRHPGFVRPVVLFGPVSDLARER----LAKDFPDKFSTPL--------QDDDKSA---- 894
            |::|         :.:||.| ...:.|..    |....||:|:.|:        :|::...
Human   736 AFKR---------KTLVLLG-AHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYF 790

  Fly   895 -----------------------ATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFY 936
                                   |..|    .:|..||.:.::|..|:||:.|.|:..|..|:|.
Human   791 VSHDQMMQDISNNEYLEYGSHEDAMYG----TKLETIRKIHEQGLIAILDVEPQALKVLRTAEFA 851

  Fly   937 PVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRD 1001
            |.|:|:...:      :..||.:  .:|.::|.::...|:|.::|.|...|..::.:...|.|.:
Human   852 PFVVFIAAPT------ITPGLNE--DESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEE 908

  Fly  1002 SIDLQQSGAVWMSES 1016
            :::|..:...|:..|
Human   909 AVELVCTAPQWVPVS 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492	15/93 (16%)
		PDZ_signaling	633..710	CDD:238492	20/81 (25%)
		SH3_ZO	729..790	CDD:212793	16/69 (23%)
		GuKc	831..1007	CDD:214504	47/218 (22%)
		ZU5	2263..2351	CDD:279170
CASK	NP_001354650.1	STKc_CASK	8..307	CDD:270996	38/201 (19%)
		Calmodulin-binding	305..315		1/9 (11%)
		L27	348..401	CDD:197794	5/52 (10%)
		L27	406..456	CDD:397114	4/49 (8%)
		Required for interaction with NRXN1 (via C-terminal tail). /evidence=ECO:0000250\|UniProtKB:Q62915	482..909		95/459 (21%)
		PDZ_signaling	488..568	CDD:238492	20/79 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..610		2/35 (6%)
		SH3_CASK	616..677	CDD:213014	16/67 (24%)
		Guanylate_kin	738..911	CDD:395500	39/194 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910