DRSC/TRiP Functional Genomics Resources

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Protein Alignment pyd and CARD11

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:NP_001311210.1 Gene:CARD11 / 84433 HGNCID:16393 Length:1154 Species:Homo sapiens


Alignment Length:1179 Identity:218/1179 - (18%)
Similarity:380/1179 - (32%) Gaps:404/1179 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 ELHEFPQQFGATGLQLVSAPKVHIAGEYLASEQQQQQQQQ------------QQQHQQVQEQQQL 136
            |:.:..||..|..||..         |.||..:|.:.:::            |:::.:::|::..
Human   134 EVIKLQQQMKAKDLQRC---------ELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDS 189

  Fly   137 GRRKAAAAAE--INLANQVYWLGKQKTRSRSRSNSVG----------NRSITSCMGGGGGGGEKE 189
            ...:.....:  .|||.:...|.::|..:..||..:.          |:....|        :.|
Human   190 YNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEEC--------KLE 246

  Fly   190 RE-----RGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETASTHSSSQRRRFKKGDRTTWEYH 249
            |.     :....:||....|.:|          :..:.:|:|.:....|                
Human   247 RNQSLKLKNDIENRPKKEQVLEL----------ERENEMLKTKNQELQS---------------- 285

  Fly   250 TVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVL---KGGPAEDRLQVNDRIISVNGVSLE 311
                         |..:|.|..|     |...|:.|:|   :....|||.::.:||.::.     
Human   286 -------------IIQAGKRSLP-----DSDKAILDILEHDRKEALEDRQELVNRIYNLQ----- 327

  Fly   312 NVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITS 376
              |.|...:.|||.    .|..|..:.|. .:..|.....:.|.:::|.|..............|
Human   328 --EEARQAEELRDK----YLEEKEDLELK-CSTLGKDCEMYKHRMNTVMLQLEEVERERDQAFHS 385

  Fly   377 LSQPNSLNSS-LVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQE 440
            ..:..:..|. |::                 ||.|      |..::|:..|              
Human   386 RDEAQTQYSQCLIE-----------------KDKY------RKQIRELEEK-------------- 413

  Fly   441 GDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNI-- 503
                        .|.|.::..::  :.|     :|.|.....:.:....||:.|........|  
Human   414 ------------NDEMRIEMVRR--EAC-----IVNLESKLRRLSKDSNNLDQSLPRNLPVTIIS 459

  Fly   504 --YATHQPQVSG-----CSSSNNNLED-----PYLPGGASYSSQNLYVQ---PPTRTSNGPNING 553
              :....|:.:|     .|:|..:.||     ||.|.....:.:.:.:|   .|.......:...
Human   460 QDFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQA 524

  Fly   554 NGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPP-------------PP 605
            .|..:|.::.:|......||.:..:..|      |.|.||:.:.....||             |.
Human   525 KGHEEEGTDASPSSCGSLPITNSFTKMQ------PPRSRSSIMSITAEPPGNDSIVRRYKEDAPH 583

  Fly   606 RGS------SGGAAQEDFYSSRRQLYEERQSAEPRFI-----SFQKEG----------------- 642
            |.:      |||....|.....    .||.|..|..|     |.|.||                 
Human   584 RSTVEEDNDSGGFDALDLDDDS----HERYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFS 644

  Fly   643 ----------SVG----------------------IRLTGGNEAGIFVTAVQPGSPASLQGLMPG 675
                      |||                      :.|.|||..|.||.:|:|||.|...||..|
Human   645 LERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREG 709

  Fly   676 DKILKV--------NDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQR------GD 726
            .::|.:        ..:.::..|:|||...:......:.|..:...|.|.::|.:..      ||
Human   710 HQLLLLEGCIRGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGD 774

  Fly   727 SFHIKTHFHCDNPSKG-EMAFKAGDVFRVIDTLHNGVVGSWQVLKIG--RGHQEMQRGVIPNKSR 788
            ||:|:.:.:..:.... .|:.|..||..|.||::.. ...|...::.  ..| ::..|.||:.||
Human   775 SFYIRLNLNISSQLDACTMSLKCDDVVHVRDTMYQD-RHEWLCARVDPFTDH-DLDMGTIPSYSR 837

  Fly   789 AEELATAQF-----NATKKEMNANE---------------------------SRGNF-------- 813
            |::|...:.     ..:::|::...                           ||.:|        
Human   838 AQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLLQF 902

  Fly   814 -------FRRRRSTHR-------RSKSLSRENWD--------------DVVFSDSISKFPAYERV 850
                   ::|..|..|       ...||:|.:.|              :.....::|..| |..|
Human   903 VSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIP-YSLV 966

  Fly   851 VLRHPGFVRPVVLFGP-------VSDLARERLAKDFP---------DKF------STPLQDDDKS 893
            ...:....|| |||.|       |..|.....|.:|.         |:|      .|.:...:|:
Human   967 RAFYCERRRP-VLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYSREKN 1030

  Fly   894 AATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLP 958
             ..:.:|  :..:||..|..:.||.||:........|..:..||:|:|::...|: ||:.|..||
Human  1031 -PNAFEC--IAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCEKN-IKRFRKLLP 1091

  Fly   959 KAAHKSSKKLLEQCQKLER---------------VWSHIFSTQIALSDEESWYRKLRDSIDLQQS 1008
            :.  ::.::.|..|:..|:               :|..:          |...|.::|.|..:|.
Human  1092 RP--ETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSV----------EELLRVVKDKIGEEQR 1144

  Fly  1009 GAVWMSESK 1017
            ..:|:.|.:
Human  1145 KTIWVDEDQ 1153

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 19/87 (22%)
PDZ_signaling 396..477 CDD:238492 10/80 (13%)
PDZ_signaling 633..710 CDD:238492 30/138 (22%)
SH3_ZO 729..790 CDD:212793 15/63 (24%)
GuKc 831..1007 CDD:214504 46/226 (20%)
ZU5 2263..2351 CDD:279170
CARD11NP_001311210.1 CARD_CARD11_CARMA1 22..107 CDD:260070
Linker. /evidence=ECO:0000305|PubMed:31296852 111..128
BAR <173..>257 CDD:299863 13/91 (14%)
GBP_C <252..418 CDD:303769 42/270 (16%)
coiled coil 387..398 CDD:293879 1/10 (10%)
coiled coil 407..418 CDD:293879 3/36 (8%)
Inhibitory domain (ID). /evidence=ECO:0000303|PubMed:31296852 450..666 42/225 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 460..626 36/175 (21%)
PDZ_signaling 680..752 CDD:238492 21/71 (30%)
SH3 777..839 CDD:302595 15/63 (24%)
NK <1009..1143 CDD:302627 31/149 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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