DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and Sdcbp

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_114192.1	Gene:	Sdcbp / 83841	RGDID:	621497	Length:	300	Species:	Rattus norvegicus

Alignment Length:	318	Identity:	70/318 - (22%)
Similarity:	115/318 - (36%)	Gaps:	102/318 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   473 NLVVLRDITNQTAVSQ--------LNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGG 529
            :|.|.:.|..|||.|.        ||:.:||:....||:|....|::|           .|:  |
  Rat     9 DLKVDKVIQAQTASSANPASQAFFLNVVDSAAFPPGGNLYPKLYPELS-----------QYM--G 60

  Fly   530 ASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSA 594
            .|.|...:       ..|.|.::|                                 .||:|:..
  Rat    61 LSLSEAEI-------CENMPVVSG---------------------------------APTQGQLV 85

  Fly   595 AIDEPPRP-------PPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGN 652
            |     ||       .|..|:..|..:.:.....|::          .:...::|.:|:||...:
  Rat    86 A-----RPSSVNYMVAPVTGNDAGIRRAEIKQGIREV----------ILCKDQDGKIGLRLKSVD 135

  Fly   653 EAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYD 717
            . ||||..||..|||||.||..||::|::|..:..|.:.::|...|              |:.:.
  Rat   136 N-GIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVL--------------KQAFG 185

  Fly   718 EVVT-NQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVI---DTLHNGVVGSWQVLKI 771
            |.:| ..|...|......|.|:.......||:|.:..::   ....||::....:.:|
  Rat   186 EKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEI 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492	1/3 (33%)
		PDZ_signaling	633..710	CDD:238492	24/76 (32%)
		SH3_ZO	729..790	CDD:212793	8/46 (17%)
		GuKc	831..1007	CDD:214504
		ZU5	2263..2351	CDD:279170
Sdcbp	NP_114192.1	Interaction with PDCD6IP. /evidence=ECO:0000250\|UniProtKB:O08992	2..104		31/152 (20%)
		LYPX(n)L motif 1. /evidence=ECO:0000250\|UniProtKB:O08992	3..7
		LYPX(n)L motif 2. /evidence=ECO:0000250\|UniProtKB:O08992	47..51		1/3 (33%)
		LYPX(n)L motif 3. /evidence=ECO:0000250\|UniProtKB:O08992	51..55		1/3 (33%)
		PDZ_signaling	114..193	CDD:238492	28/103 (27%)
		PDZ_signaling	198..271	CDD:238492	8/46 (17%)
		phosphatidylinositol-4, 5-bisphosphate-binding. /evidence=ECO:0000250\|UniProtKB:O00560	252..253
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910