DRSC/TRiP Functional Genomics Resources

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Protein Alignment pyd and GRIP2

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:XP_011532443.1 Gene:GRIP2 / 80852 HGNCID:23841 Length:1050 Species:Homo sapiens


Alignment Length:1183 Identity:240/1183 - (20%)
Similarity:391/1183 - (33%) Gaps:391/1183 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 GGEKERERGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETASTHSSSQRRRFKKGDRTTWEYH 249
            |..:.|.:|.| |.||.:.        ||..||         |....:.:|:...:      |:.
Human    11 GVVRRRLKGAD-DGPYSKG--------GKDAGG---------ADVSLACRRQSIPE------EFR 51

  Fly   250 TVAVTRV---PGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPA--EDRLQVNDRIISVNGVS 309
            .:.|..:   .|...|:.:|||.|.    :|.|  .||::..||.|  .|.|.:.|.|.||||:.
Human    52 GITVVELIKKEGSTLGLTISGGTDK----DGKP--RVSNLRPGGLAARSDLLNIGDYIRSVNGIH 110

  Fly   310 LENVEYATAVQVLRDSGNTVQLVVKRRVP-----LNPI--------------NAAGAV----QHQ 351
            |..:.:...:.:|::.|..|.|.|:..:|     .||.              |:.|.|    .|:
Human   111 LTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHE 175

  Fly   352 HSHSLSSVGLMANGSGGVAP----------------TPITSLSQPNSL----------------- 383
            ..|....:.|.....||.|.                .|:...|...:|                 
Human   176 DGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYD 240

  Fly   384 --NSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKA---------REQLNANGYS 437
              ....|.|||....:::..|.|.       .||..|....:.:|:         ...::.:| :
Human   241 VATPDTVANASGPLMVEIVKTPGS-------ALGISLTTTSLRNKSVITIDRIKPASVVDRSG-A 297

  Fly   438 LQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGN 502
            |..||.|..|..|:. :..||.||.|::....|::.|.:|....:|   ..|..:.:...|.|..
Human   298 LHPGDHILSIDGTSM-EHCSLLEATKLLASISEKVRLEILPVPQSQ---RPLRPSEAVKVQRSEQ 358

  Fly   503 IYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRG 567
            :: ...|.|..|.|..        ||         :.:.||..                  ||.|
Human   359 LH-RWDPCVPSCHSPR--------PG---------HCRMPTWA------------------TPAG 387

  Fly   568 RSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEP---PR---PPPPRGSSGGAAQEDFYSSRRQLYE 626
            :.:...:......      :||...:.:.:.|   ||   |..||.:.|         .|||...
Human   388 QDQSRSLSSTPFS------SPTLNHAFSCNNPSTLPRGSQPMSPRTTMG---------RRRQRRR 437

  Fly   627 ERQSAEPRFISFQKEG-------------------SVGIRLTGGNEAGIFVTA----------VQ 662
            |.:|:.....|....|                   ..|::|.|    |||.|.          ::
Human   438 EHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQG----GIFATETLSSPPLVCFIE 498

  Fly   663 PGSPASLQGLMP-GDKILKVNDMDMNGVTREEAVLFL--LSLQDRIDLIVQYCKEEYDEVVTNQR 724
            |.|||...||:. ||::|.:|.:.....|.|||...|  .:|..::.|.|::   :..|.|....
Human   499 PDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEF---DVAESVIPSS 560

  Fly   725 GDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRA 789
            | :||:|                                                   :| |.|:
Human   561 G-TFHVK---------------------------------------------------LP-KKRS 572

  Fly   790 EELATAQFNATKKE----MNANESRGNFFRRRRSTHRRSKSLSREN--WDDVVFSDSISKFPAYE 848
            .||.....:|::|.    :.::..:|:...|..:.....|.|:.:|  .|:....|::.      
Human   573 VELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQ------ 631

  Fly   849 RVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMD 913
              :||.            ..||.:.::.||         :|:.....|:|     .:|...::..
Human   632 --ILRQ------------CEDLVKLKIRKD---------EDNSDELETTG-----AVSYTVELKR 668

  Fly   914 RGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERV 978
            .|  ..|.||.:..:.    .|.|:||              .||.|      :.|.|:...:   
Human   669 YG--GPLGITISGTEE----PFDPIVI--------------SGLTK------RGLAERTGAI--- 704

  Fly   979 WSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSESKPVESLSDDFLFPMTTSRLSYASSPES 1043
              |:....:|:::.....|.|.::|.|.|  ....:.:..::...|..|.|..:..||..|..:.
Human   705 --HVGDRILAINNVSLKGRPLSEAIHLLQ--VAGETVTLKIKKQLDRPLLPRKSGSLSETSDADE 765

  Fly  1044 DLELSPGPSASLSLGNLPQLVKASSDPSIATNQDNLDRDRDIIGEGLPPPYTVPYDHAVPANPNR 1108
            |      |:.:|. |.||....:.:.||:.:..::.|......|.|.|..||       |....|
Human   766 D------PADALK-GGLPAARFSPAVPSVDSAVESWDSSATEGGFGGPGSYT-------PQAAAR 816

  Fly  1109 RQTMDSSKYSIYGTNVPPQQQQPGVGGDTAAVRPQSLYGINAPDLPPRIDRQSKPGD--IPLNTS 1171
            ..|              ||:::||           .|.|...|..|.|......|.|  .|....
Human   817 GTT--------------PQERRPG-----------WLRGSPPPTEPRRTSYTPTPADESFPEEEE 856

  Fly  1172 GSSSRNGTL---GRSAQE---RLFGKAVVQDDV----QAEYITRNALVGSGAAETLDRQQQQQQQ 1226
            .......|.   |.:.:|   |:||:|:  :|:    |:|.:  ..|..|....|:.|...:.:.
Human   857 EDDWEPPTSPAPGPAREEGFWRMFGEAL--EDLESCGQSELL--RELEASIMTGTVQRVALEGRP 917

  Fly  1227 THASLERQARLNA 1239
            .|...:|...:.|
Human   918 GHRPWQRGREVRA 930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 27/89 (30%)
PDZ_signaling 396..477 CDD:238492 20/89 (22%)
PDZ_signaling 633..710 CDD:238492 26/108 (24%)
SH3_ZO 729..790 CDD:212793 5/60 (8%)
GuKc 831..1007 CDD:214504 32/177 (18%)
ZU5 2263..2351 CDD:279170
GRIP2XP_011532443.1 PDZ_signaling 53..135 CDD:238492 27/87 (31%)
PDZ_signaling 155..238 CDD:238492 12/82 (15%)
PDZ_signaling 253..336 CDD:238492 20/91 (22%)
PDZ_signaling 461..549 CDD:238492 24/91 (26%)
PDZ_signaling 562..645 CDD:238492 21/154 (14%)
PDZ_signaling 662..742 CDD:238492 20/112 (18%)
PDZ_signaling 947..1026 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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