DRSC/TRiP Functional Genomics Resources

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Protein Alignment pyd and rapgef6

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:NP_001361718.1 Gene:rapgef6 / 733941 XenbaseID:XB-GENE-981546 Length:1644 Species:Xenopus tropicalis


Alignment Length:1899 Identity:346/1899 - (18%)
Similarity:577/1899 - (30%) Gaps:656/1899 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 TMDPRFPLELHEFPQQFGATGLQLVSAPKVHIAGEYLASEQQQQQQQQQQQHQQVQEQQQLGRRK 140
            :::|||...|.:.|::.....|:.|.:        |:       .:.....|.:   :.||....
 Frog     4 SIEPRFKEALRKKPKERTQEDLKTVYS--------YM-------HRMDILSHLR---EHQLRLMS 50

  Fly   141 AAAAAEINLANQVYWLGKQKTRS----RSRSNSVGNRS-ITSCMGGGGGGGEKERERGGD----- 195
            |.|..|...||||.:..:...|.    .|.|..|.|.. :..|..|...||    :||.|     
 Frog    51 ATARYERYSANQVLFCSESLARCWYILLSGSVLVKNSMFLPPCSFGKQSGG----KRGCDCIVLE 111

  Fly   196 -RDRPYIRNVDDLLQALGKRDGGDNNSNLL--ETASTHSSSQRRRFKK----GDRTTWEYHTVA- 252
             .:...:.|.            |:||..:|  ||:...|   |||::|    |:|.|...:..| 
 Frog   112 PSEMIVVENT------------GENNDGILHRETSIRQS---RRRYRKINQHGERQTITDNGDAA 161

  Fly   253 ---------------------VTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRL 296
                                 ||.||....|.::         |:...|.::||:.:...:|   
 Frog   162 SYVLLPTDLSKIHLTDSPHPHVTHVPSSQSGCSI---------ASDSGSSSLSDIYQATESE--- 214

  Fly   297 QVNDRIISVNGV-----------SLENVEYATAVQVLRD--------------SGNTVQLV---- 332
             :.|  :.:.|:           ..|::|.|:...:.||              ..:..||:    
 Frog   215 -MGD--VDLTGLPEAAVDSEDEEEDEDIERASDTMLTRDIVRECLEKEPTDRTDDDIEQLLEFMH 276

  Fly   333 -----------VKRR----VPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNS 382
                       |:|:    :....:..|||:..:....|.|..::.||        |..:|..:.
 Frog   277 QLPAFVNMTMSVRRKLCSVMIFEVVEQAGAIIIEDGQELDSWYVILNG--------IVEISHSDG 333

  Fly   383 LNSSLVQNASSG-QPIKVTLTKGG----KKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGD 442
            ...:|....|.| .|...|....|    |.||...|  |  ..::...:....:..|.:.::|..
 Frog   334 RMENLCMGNSFGINPSLETQYMDGVVKTKADDCQFV--C--IAQQDYFRILNHVEKNTHKVKEKG 394

  Fly   443 IITRIHNTNCGDTMSLKEAKKIIDGCKER--LNLVVLRDITNQTAVSQLNLNNSASHQASGNIYA 505
            .|..::.....|....::...:|.|..||  |:|:....:.:.|.:....|.           |.
 Frog   395 EIVMVNEHRELDRSGTRKGHIVIQGTPERLILHLIEEHSVVDPTYIEDFLLT-----------YR 448

  Fly   506 THQPQVSGCSSSNNNLEDPYLPGGASYSSQN-------LYVQPPTRTSNGPNINGNGLNDEKSNL 563
            |.       .||...:.|..|......|.::       |:|             .|..||.:.: 
 Frog   449 TF-------LSSPLEVGDKLLEWFKDDSRRDKVTRVVLLWV-------------NNHFNDFEGD- 492

  Fly   564 TPRGRSRGPIMDGVSLQQLDRPV-----------------TPTRGRSAAIDEPPRPPPPRGSSGG 611
                    |.|... |::.:|.:                 ...:.|...:.:|.|..|       
 Frog   493 --------PAMTRF-LEEFERNLENAKMKGHLRLLNIACAAKAKLRQVTLLKPSRESP------- 541

  Fly   612 AAQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEA--GIFVTAVQPGSPASLQGLMP 674
                 ||                           ..:.||::.  |:|:.:|:|||.|:..||..
 Frog   542 -----FY---------------------------FNVVGGSDKGFGMFIESVEPGSKATEAGLKR 574

  Fly   675 GDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNP 739
            ||:|::||..:.      |.:::..:|                |::.|....|..:||:.     
 Frog   575 GDQIMEVNGQNF------ETIVYAKAL----------------EILKNNTHLSITVKTNI----- 612

  Fly   740 SKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEM 804
                ..||. .:.|:.....|||.   .:.||  ..::..|..||:.....|....:..|:|| |
 Frog   613 ----FVFKE-LLNRIGQEKKNGVP---HIPKI--AEKKNNRYSIPDLPNDVEQMFPRDRASKK-M 666

  Fly   805 NANESRGNFFRRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSD 869
            .||...|...|.|:                                                :.|
 Frog   667 KANTVSGGRNRIRK------------------------------------------------ILD 683

  Fly   870 LARERLAKDFPDKFSTPLQDDDKSAATSGKCR-IVRLSNIRDVMDRGKHALLDITPNAVDRLNYA 933
            ..|..:....|......:|..|.|...:.:|| .|.:..|...:......||..|.|.:|..|..
 Frog   684 KTRFSILPPKPFSDGHVIQSQDDSIVGTRQCRHSVAIMPIPGTLSSSSPDLLQATTNILDFSNPT 748

  Fly   934 QF--------------------YPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERV 978
            .|                    | ::|...|.:|.|:.|..|.........:..|.|.....|.|
 Frog   749 AFGFYYIPDQVIRIFKADQQCCY-IIIGKDTTAKEVVIQALHEFSLTGSTDTYSLCEVSVSPEGV 812

  Fly   979 WSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSESKPVESLSDD------------FLFPMT 1031
                 ..|..|.|:.|   ||.|.|.|  :|..::..:...|:|..|            .|..::
 Frog   813 -----IKQRRLPDQLS---KLADRIQL--NGRYYLKNNMETETLCSDEDAQELLRESLISLLQLS 867

  Fly  1032 TSRLSYASSPESDLEL--SPGPSASLSLGNLPQLVKASSDPSIA--------TNQDNLDRDRDII 1086
            |..::...|.. |.||  :..|:..:.     .|.|..|..|.|        .||:......:|:
 Frog   868 TIEVATQLSMR-DFELFRNIEPTEYID-----DLFKIDSKTSAAHLKQFEEVINQETFWVATEIL 926

  Fly  1087 GEGLPPPYTVPYDHAVPANPNRRQTMDSSKY-------------------SIYGTNVPPQQQQPG 1132
            .|                 ||..:.|...|:                   .|.|.|:.|..:..|
 Frog   927 RE-----------------PNHLKRMKIVKHFIKTALHCRECRNFNSMFAIISGLNLAPVARLRG 974

  Fly  1133 VGGDTAAVRPQSLYGINAPDL--PPR--------IDRQS-KPGDIPLNT----------SGSSSR 1176
            ......:...:.|..:.  ||  |.|        :..|| :|..|||..          .|:.|:
 Frog   975 TWEKLPSKYEKLLRDLQ--DLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDITFLHEGNDSK 1037

  Fly  1177 NGTLGRSAQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLERQARLNAQL 1241
            ...|....:.|:..|.:       .::.|........| .:.||::::.::..||.:     ...
 Frog  1038 VDGLVNFEKLRMIAKEI-------RHVIRMTSANMDPA-VMFRQRKKRWRSLGSLSQ-----GST 1089

  Fly  1242 KANGVGAGGGGASTYDSVSSY----DSYNNTQMA------MQNL--------------------G 1276
            .:|.:...|||.......||:    ..|.:.||:      :.||                    .
 Frog  1090 NSNMLDVQGGGHKKRARRSSFLNAKKLYEDAQMSRKVKQYISNLSVEIDEEKIQLMSLQCEPAYS 1154

  Fly  1277 RLGPNAPDDLKSVPNANGRPLPPTGQSHEYGRTPHDHRSFGGPNDLN-------------RQSSP 1328
            .|..|..:...:..:.:..||.|:||:.:    .|.|:.    |.::             |:.:|
 Frog  1155 TLAKNLSERRSAKSDLSPAPLRPSGQTTK----AHIHQQ----NRMSQVLQVPTVNLYPMRKKAP 1211

  Fly  1329 GRPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRKPLVETKTDYGKYSRNNSVTQADYTKLPKTA 1393
            .:.|         :...:|:.|:.|.|..|.:.:..|.::.:.......:.:.:       |:.:
 Frog  1212 TKEH---------LPCTSGSSQKISGLTDEVTVKAQLEDSVSLVSSLHSSPAAS-------PQGS 1260

  Fly  1394 PHGVVPPPNVSNGQ--GQMNGSGTPSSNGSGPFKPV-------------PPPKPKNYRPPVQSGG 1443
            ||.||   |:|..:  ..||.||:.||..|.|.:.:             |..|..|:.....|..
 Frog  1261 PHKVV---NISRSENSSHMNLSGSSSSLTSDPNQKICSRRGYGIGYAHNPSAKSDNFSDSSNSEI 1322

  Fly  1444 SSGSG-----------------GTTPWENGDSG--SPRS---PNGFYYPPT--------PSHHHY 1478
            ||.|.                 ...|..:.:|.  |.|.   |:..|..|.        |:..::
 Frog  1323 SSRSSLVSNCSVDSMSLTLQDEKCVPHSHAESMGLSERKDVHPSSEYNQPCSSWLHARHPAVRNF 1387

  Fly  1479 GQQATPGSPSNGHMQPPPPQQQQPTY----GGSNGN-------------YGQAPPPQSYPQANGY 1526
            ...|:....::.|:...|....:.::    ..|:.|             |.|:.......:....
 Frog  1388 IACASSEDIAHDHISVEPVDSGRGSWTSCSSSSHDNFQTLQKGLDRLSTYRQSHIDSPIAETESA 1452

  Fly  1527 N-------------GNGHHYN------------GGSGTGPYIAPHRGMPPPIGNLPPHTPERHAL 1566
            |             |..|..|            ..|........:.|           |.:|..|
 Frog  1453 NCSTDETCSEDCTKGKRHSNNSLELNESRQSWASSSSMSDTYETNYG-----------TIKRRVL 1506

  Fly  1567 DLAGSREQRGSAFELYRKPQIGATAGHHHNMSEMEPY---DERYDDYYNMPPPAAHPSQGHHMQR 1628
            |.....|..|...:::.|.....|.      ..:..|   ..:.|..|..|||.....||..:..
 Frog  1507 DTEEKTEALGQQLDVFYKTVTSTTE------KGLIVYCVTSSQKDSRYREPPPTPPGYQGISLAD 1565

  Fly  1629 SRSA-PRYPHERPP 1641
            .:.. |...|.:||
 Frog  1566 IKEGQPHQAHLKPP 1579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 20/146 (14%)
PDZ_signaling 396..477 CDD:238492 18/86 (21%)
PDZ_signaling 633..710 CDD:238492 18/78 (23%)
SH3_ZO 729..790 CDD:212793 13/60 (22%)
GuKc 831..1007 CDD:214504 37/196 (19%)
ZU5 2263..2351 CDD:279170
rapgef6NP_001361718.1 CAP_ED 37..119 CDD:381773 22/88 (25%)
CAP_ED 280..380 CDD:237999 22/111 (20%)
RasGEFN 412..525 CDD:214571 24/153 (16%)
PDZ_signaling 528..609 CDD:238492 27/141 (19%)
RA_PDZ-GEF1 758..840 CDD:340483 21/92 (23%)
RasGEF 863..1097 CDD:214539 48/271 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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