DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and Card14

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_038943446.1	Gene:	Card14 / 688292	RGDID:	1591135	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	146/691 - (21%)
Similarity:	247/691 - (35%)	Gaps:	198/691 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 DTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNN------SASHQASGN---------- 502
            |...::.::::::  |:.|...|. ::|.|....:..|..      ....|.:||
  Rat   390 DRAQMEISQRLVE--KDALRRRVF-ELTEQVCELRTQLRRLQAEAPGGPKQEAGNREICLRGKQR 451

  Fly   503 ---IYATHQPQVSGCS----------------SSNNNLE-----DPYLPGGASYSSQNLYVQPPT 543
               ::|...|..|.||                ||...::     .|..|     |.|:||.:...
  Rat   452 LVRMHAVCPPDDSDCSFLSSTESRLWWDLNSTSSREQMDSFRSSSPMPP-----SQQSLYKRVAE 511

  Fly   544 RTSNGP-----------NINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAID 597
            .....|           .:.|..|:|..::|      ...::||..|.|.:..:..: .||..:.
  Rat   512 DFLEDPESLSLPEVLEVRLQGATLDDTDTDL------EFEMLDGADLSQTEDSLQGS-SRSLNVS 569

  Fly   598 E---PPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEG---SVGIRLTGGNEAGI 656
            |   |.|..|.|                     :..::...::||.:.   .:|:  .|||..||
  Rat   570 ESSVPVRRRPAR---------------------KILSQVTVLAFQGDALLEQIGV--IGGNLTGI 611

  Fly   657 FVTAVQPGSPASLQGLMPGDKILKVN--------DMDMNGVTREEAVLFLLSLQDRIDLIVQYCK 713
            |:..|.|||.|....|.||.:|:.|:        ...:...|.|:||..|..:.....|.|:...
  Rat   612 FIHRVTPGSAADEMALRPGTQIMMVDYKPTKPSLRATLENTTLEQAVGLLRRVNGSCYLSVKINT 676

  Fly   714 EEYD--------EVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLK 770
            |.|.        :|||:  ||||:|:.:.......:||:.....|:..|.||:..| ...|....
  Rat   677 EGYKNLIQDLDAKVVTS--GDSFYIRVNMAMQRRGEGELHAHCNDILHVTDTMFQG-RSCWHAHH 738

  Fly   771 IG-RGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFF---RRRRSTHRRSKSLSRE- 830
            :. ...::|:.|.|||.|:|::...|......:........|:..   .|...|.....|||:.
  Rat   739 VNPYTMKDMEPGTIPNYSQAQQQLLALIQDMTQRCTVARKVGHLVLLGHRTPFTLSTHLSLSKPP 803

  Fly   831 ----------NWDDVVFSDSISKF-------------PA-------------YERVVLRHPGFVR 859
                      :.|....|...|.|             |:             |..|....|.:.|
  Rat   804 GGPQKLVRIVSVDKAAVSPLTSSFDQGQEDSGKEEGGPSVCFWPENCFTLAPYTLVHPHRPAWPR 868

  Fly   860 PVVLFGP----------------VSDLARERLAKDFPDKFSTPLQDDD--KSAATSGKCRIVRLS 906
            | |||.|                ....:.|.|::   :::.|..|..|  :...:.|....|...
  Rat   869 P-VLFVPRVIGKILGKKLCLLQGFKQCSAEYLSQ---EEYVTWSQRGDIIQEGESIGDHHCVTRH 929

  Fly   907 NIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQ 971
            .::.:|:...|||||:..::|..|:....:|::|.:..:.| ..|:||.||.:.. .|.::.||.
  Rat   930 AVQSLMNTSTHALLDVRLDSVRVLHKMDIFPIIIHVSVNEK-TAKKLRKGLHRLG-SSEEQFLEV 992

  Fly   972 CQ----KLERV-----------WSHIFS----TQIALSDEE 993
            .:    :|:||           ||.:.|    .::|::||:
  Rat   993 ARQEEGELDRVPCLYSSLAPDNWSDLDSLLNCVRLAIADEQ 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492	3/22 (14%)
		PDZ_signaling	633..710	CDD:238492	25/87 (29%)
		SH3_ZO	729..790	CDD:212793	15/61 (25%)
		GuKc	831..1007	CDD:214504	49/226 (22%)
		ZU5	2263..2351	CDD:279170
Card14	XP_038943446.1	DD	19..104	CDD:417479
		SMC_prok_B	135..>430	CDD:274008	7/42 (17%)
		PDZ_signaling	601..673	CDD:238492	23/73 (32%)
		SH3	698..759	CDD:418401	15/61 (25%)
		NK	<898..1005	CDD:418433	28/111 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910