Protein Alignment pyd and PALS1

DIOPT Version :9

• Sequence 1: NP_001246998.1
• Gene: pyd / 41062
• FlyBaseID: FBgn0262614
• Length: 2395
• Species: Drosophila melanogaster
• Sequence 2: NP_071919.2
• Gene: PALS1 / 64398
• HGNCID: 18669
• Length: 675
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 91/433 - (21%)
• Similarity: 175/433 - (40%)
• Gaps: 71/433 - (16%)

  Fly   634 RFISFQKEGSVGIRLTGGNEA-GIFVTAVQPGSPASLQGLM-PGDKILKVNDMDMNGVTREEAVL 696
            :.:..:|...:.:..|..||. .:.::.:..|..|...||: .||::|::|.:::.|....|...
Human   255 KIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFD 319

  Fly   697 FLLSLQDRIDLIV----QYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGE--------MAFKAG 749
            .|..:...:..::    |.......|.|       .|:|.||..| ||...        ::|:.|
Human   320 LLSDMHGTLTFVLIPSQQIKPPPAKETV-------IHVKAHFDYD-PSDDPYVPCRELGLSFQKG 376

  Fly   750 DVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFF 814
            |:..||.   ......||..:.|....:...|::|.||..::  ......|.:|....|..|..:
Human   377 DILHVIS---QEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQ--REAMKQTIEEDKEPEKSGKLW 436

  Fly   815 RRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRH--PGFVRPVVLFGPVS---DLARER 874
            ..:::..:|.|.|...|.:|...::.|.   .||.:.|.|  ....||::|.||.:   :..|:|
Human   437 CAKKNKKKRKKVLYNANKNDDYDNEEIL---TYEEMSLYHQPANRKRPIILIGPQNCGQNELRQR 498

  Fly   875 LAKDFPDKFSTPLQDDDKSA---------------------ATSGK----------CRIVRLSNI 908
            |.....|:|::.:....:|.                     ..:||          .....:.::
Human   499 LMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSV 563

  Fly   909 RDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQL--RHGL-PKAAHKSSKKLLE 970
            |.|::.||..||.:...::..|..:...|.:||:...|:..::.|  :.|. ||.  :..::::|
Human   564 RQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKP--EELREIIE 626

  Fly   971 QCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWM 1013
            :.:::|:...|.|.|.|..||.:..|::|...|:...:...|:
Human   627 KTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWV 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492	15/81 (19%)
		SH3_ZO	729..790	CDD:212793	19/68 (28%)
		GuKc	831..1007	CDD:214504	46/214 (21%)
		ZU5	2263..2351	CDD:279170
PALS1	NP_071919.2	Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2	1..345		16/89 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2	21..140
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..78
		L27_N	123..170	CDD:401122
		Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2	181..243
		L27	189..237	CDD:197794
		PDZ_signaling	254..333	CDD:238492	15/77 (19%)
		SH3_MPP5	349..411	CDD:212969	17/65 (26%)
		GuKc	491..661	CDD:214504	34/171 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910