DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and Dlg3

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_006257142.1	Gene:	Dlg3 / 58948	RGDID:	68423	Length:	867	Species:	Rattus norvegicus

Alignment Length:	884	Identity:	212/884 - (23%)
Similarity:	347/884 - (39%)	Gaps:	273/884 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 GDRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPA--EDRLQVNDRII 303
            |....::|..:.:.| ...|.|.:::||.||||..: ||.|.::.::.||.|  :.||.|||.::
  Rat   140 GSDGMFKYEEIVLER-GNSGLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAAMDGRLGVNDCVL 202

  Fly   304 SVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVP----LNPIN-----------AAGAVQHQHS 353
            .||.|.:..|.::.||:.|:::|..|:|||:||.|    :..:|           .||.:.:||.
  Rat   203 RVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHI 267

  Fly   354 HSLSSVGLMANGSGGVAPTPITSLSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRL 418
            ...:|:.:.....||.|                               .|.|:
  Rat   268 PGDNSIYITKIIEGGAA-------------------------------QKDGR------------ 289

  Fly   419 FVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQ 483
                               ||.||.:..::|||                         |:|:.::
  Rat   290 -------------------LQIGDRLLAVNNTN-------------------------LQDVRHE 310

  Fly   484 TAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNG 548
            .||:.|.       ..|..:|      :......:.:|.|.|.|  ..|:|        |.|:..
  Rat   311 EAVASLK-------NTSDMVY------LKVAKPGSLHLNDMYAP--PDYAS--------TFTALA 352

  Fly   549 PN-INGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGA 612
            .| |:.|.             |.|      .|..::..||        ...||:.||.|
  Rat   353 DNHISHNS-------------SLG------YLGAVESKVT--------YPAPPQVPPTR------ 384

  Fly   613 AQEDFYS--SRRQLYEERQSAEPRFISFQKEGSVGI--RLTGGNEA-GIFVTAVQPGSPASLQG- 671
                 ||  .|..|.||..:.|||.|...| ||.|:  .:.||.:. ||||:.:..|.||.|.|
  Rat   385 -----YSPIPRHMLAEEDFTREPRKIILHK-GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGE 443

  Fly   672 LMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEY-----------DEVVTNQRG 725
            |..||:||.||.:::...|.|:|...|......:.::.||..|||           ::::.:...
  Rat   444 LRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMS 508

  Fly   726 D-----------SFHIKTHFHCDN------PSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGR 773
            .           |.:::..|..|.      ||:| ::|..||:..||    |.....|...::..
  Rat   509 SGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQG-LSFSYGDILHVI----NASDDEWWQARLVT 568

  Fly   774 GHQEMQR-GVIPNKSRAEE-----LATAQFNA------------TKKEMNANESRGNFFRRRRST 820
            .|.|.:: ||||:|.|.|:     |.|.:|:|            ||::.:...||...|.:.:..
  Rat   569 PHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKEN 633

  Fly   821 HRRSKSLSRE----NWDDVVFSDSISK-----FPAYERVVLRHPGFVRPVVLFGPVSDLARERLA 876
            ..:.||:..:    |..|   |:|.||     ..:||.|..:...:.|||::.||:.|...:.|.
  Rat   634 MAQEKSIQEQGVTSNTSD---SESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLI 695

  Fly   877 KDFPDKFST-------PLQDD---------------------DKSAATSGKCRI----VRLSNIR 909
            .:||.||.:       |.:|:                     |.....:|:...    ..:.::|
  Rat   696 SEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVR 760

  Fly   910 DVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQK 974
            .|.:||||.:||::.||:.||..||.||:.||:|..|...:.::..   :..::.:.|:.::..|
  Rat   761 AVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNR---RQTYEQANKIFDKAMK 822

  Fly   975 LERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWM 1013
            ||:.:...|:..:.....|..|.|::..|:.|....:|:
  Rat   823 LEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWV 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	31/86 (36%)
		PDZ_signaling	396..477	CDD:238492	9/80 (11%)
		PDZ_signaling	633..710	CDD:238492	29/80 (36%)
		SH3_ZO	729..790	CDD:212793	20/67 (30%)
		GuKc	831..1007	CDD:214504	53/212 (25%)
		ZU5	2263..2351	CDD:279170
Dlg3	XP_006257142.1	MAGUK_N_PEST	52..148	CDD:287565	1/7 (14%)
		PDZ_signaling	149..226	CDD:238492	27/78 (35%)
		PDZ_signaling	242..328	CDD:238492	25/185 (14%)
		PDZ_assoc	329..403	CDD:287558	28/121 (23%)
		PDZ_signaling	402..480	CDD:238492	29/78 (37%)
		SH3_DLG3	520..586	CDD:212962	21/70 (30%)
		Guanylate_kin	676..854	CDD:279019	44/180 (24%)
		GuKc	687..854	CDD:214504	39/169 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910