DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and Apba3

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_061228.1	Gene:	Apba3 / 57267	MGIID:	1888527	Length:	571	Species:	Mus musculus

Alignment Length:	193	Identity:	47/193 - (24%)
Similarity:	79/193 - (40%)	Gaps:	58/193 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 VAVTRVPGYGFGIA-VSGGRDNPHFANGDPSIAVSDVLKGGPAE--DRLQVNDRIISVNGVSLEN 312
            |.:.:.||.|.|:| |..|     :.:..|:..::::|.|||||  ..|.:.||:.::||.||..
Mouse   392 VCIQKRPGEGLGVALVESG-----WGSLLPTAVIANLLHGGPAERCGALSIGDRVTAINGTSLVG 451

  Fly   313 VEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITS- 376
            :..|.....:|:        |:|                    ||||.|..     :...|:|:
Mouse   452 LSLAACQAAVRE--------VRR--------------------LSSVTLSI-----IHCPPVTTA 483

  Fly   377 -LSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSL 438
             :.:|: :...|......|  |..:|.:||..:..||.:|.|:            :..||.|:
Mouse   484 VIRRPH-VREQLGFCVEDG--IICSLLRGGAAERGGVRVGHRI------------IEVNGQSV 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	24/85 (28%)
		PDZ_signaling	396..477	CDD:238492	11/43 (26%)
		PDZ_signaling	633..710	CDD:238492
		SH3_ZO	729..790	CDD:212793
		GuKc	831..1007	CDD:214504
		ZU5	2263..2351	CDD:279170
Apba3	NP_061228.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..195
		PTB_X11	209..361	CDD:269919
		PDZ_signaling	390..475	CDD:238492	31/120 (26%)
		PDZ_signaling	480..548	CDD:238492	15/67 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910