DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and mpp3a

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_021330373.1	Gene:	mpp3a / 572079	ZFINID:	ZDB-GENE-130530-555	Length:	613	Species:	Danio rerio

Alignment Length:	700	Identity:	130/700 - (18%)
Similarity:	244/700 - (34%)	Gaps:	238/700 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 LKEAKKIID---GCKERL---------------NLVVLRDITNQTAVSQLNLNNSASHQASGNIY 504
            :|||..::.   |..|.|               ::|.|||:.::.::|.|...:....|     |
Zfish     1 MKEAMPVLSAGGGLHETLALLTSQLRPDANHKEDMVFLRDVFSERSLSCLMKIHEKLRQ-----Y 60

  Fly   505 ATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNL-----T 564
            ....|             .|.|     :|:..|.........:||      ::.|:..|     :
Zfish    61 EKQSP-------------TPVL-----HSASTLAEDVAEELQSGP------MSVEEKELLHLLTS 101

  Fly   565 PRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEER- 628
            |..::...:.|.|:.:..|               |..||.|         :||   ..:|.||.
Zfish   102 PHLKAVLSVHDTVAQKNFD---------------PVLPPLP---------DDF---EDELDEESV 139

  Fly   629 ------QSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLM-PGDKILKVNDMDM 686
                  ::.||...:.:::.|.|         .:.|..:..|..|...||: .||::.:||...:
Zfish   140 KIVRLVKNKEPLGATIRRDESTG---------AVIVARIMKGGAADRSGLVHVGDELREVNGSSV 195

  Fly   687 NGVTREEAVLFLLSLQDRIDL-IVQYCKEEYDEVVTNQRGDSFHIKTHFH----------CDNPS 740
            .....:|....|...|..|.| |:...||| |::..|:    .:::..|.          |   .
Zfish   196 MHKRPDEISQLLSQSQGSITLKIIPAIKEE-DKLQENK----VYMRALFDYTPLEDKATPC---Q 252

  Fly   741 KGEMAFKAGDVFRVI---DTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAE-------ELATA 795
            :..:.||.|||.:|:   |...      ||..:|  |...::.|::|:|...|       ::.|.
Zfish   253 EAGLPFKRGDVLQVVSQDDQTW------WQAKRI--GDCNLRAGLVPSKQFQERRLAYRIKMGTL 309

  Fly   796 QFNATKKEMNANES--------RGNF---------------------------------FRRRRS 819
            |.:.:.|:...::.        .|.|                                 ||..|.
Zfish   310 QNSKSPKKAVYDQGCDKEDCDCEGYFNGQYIVSSKCNAVAPSCGQVFSWDFYSAGLRRSFRLSRK 374

  Fly   820 THRRSK---SLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGP----VSDLARERLAK 877
            ..|.|.   ::|.:|..|.:..:.:::   |::.....|   |.|||.|.    :::|.::.:|:
Zfish   375 DRRGSSGEANVSDQNDTDFLTYEEVTR---YQQRSNERP---RLVVLIGSLGARINELKQKVIAE 433

  Fly   878 DFPDKFST-------PLQDDDKSA------------ATSGKCRIVR------------LSNIRDV 911
            : |.:::.       |.:..:|..            |.:...:.:.            :..||.|
Zfish   434 N-PHRYAVAVPHTTRPKKSHEKEGVEYHFVTKQAFDADAQNNKFIEYGEYKENLYGTSIEAIRSV 497

  Fly   912 MDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLR-------------HGLPKAAHK 963
            ..:.|..|:|:.|.|:..|..|:|.|.|||:|..    |.:.|             ||  :...:
Zfish   498 QAKNKMCLVDVQPEALKALRTAEFKPYVIFVKPK----IPESRRRRSAATSPGGGEHG--RITEE 556

  Fly   964 SSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWM 1013
            ..:::....|::::.:.|:....:...|..|...:||..::..:....|:
Zfish   557 DLQEMRLSAQQIDQQYGHLVDRVLIKEDTASASTELRSILERLERETFWV 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492	7/36 (19%)
		PDZ_signaling	633..710	CDD:238492	18/78 (23%)
		SH3_ZO	729..790	CDD:212793	16/73 (22%)
		GuKc	831..1007	CDD:214504	41/223 (18%)
		ZU5	2263..2351	CDD:279170
mpp3a	XP_021330373.1	L27	15..66	CDD:308467	11/68 (16%)
		L27	73..123	CDD:308467	10/70 (14%)
		PDZ_signaling	139..219	CDD:238492	18/88 (20%)
		SH3	234..295	CDD:327375	16/71 (23%)
		GuKc	426..597	CDD:214504	32/177 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910