DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and lnx2b

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	610	Identity:	131/610 - (21%)
Similarity:	220/610 - (36%)	Gaps:	169/610 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 RERGGDRDRPYIRNVDDLLQALGKRDGGD-----NNSNLLETASTHSSSQ----RRRFKKG-DRT 244
            ||....:.||....:.      |.:..||     :...:..||...:.|:    ...|::| |.|
Zfish   140 REEAERKKRPSWNELK------GSKSDGDLADAKSAQTIGRTAQLSAPSEPGLVNPAFEEGEDDT 198

  Fly   245 TWEYHTVAVTRV-------PGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGG--PAEDRLQVND 300
            ......||...|       ||...|:.:.||:|.| ..|    |.:.::::..  ..:.:|...|
Zfish   199 PLRCSLVAEATVVELFREDPGEDLGLRIVGGKDTP-LGN----IVIQEIVRDSLVARDGKLAPGD 258

  Fly   301 RIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANG 365
            .|:.||.|||.::.::.|:.|:|...:.::|.|.:.....|     ..:|....|.|
Zfish   259 HILEVNDVSLASISHSRAIAVIRQPCSRLRLTVMQEKGFKP-----RPEHHTQPSAS-------- 310

  Fly   366 SGGVAPTPITSLSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCR-----LFVKEI-- 423
                .||...|.:|            :.|..|:|||.|..:.:..|:.|..:     :|:.::
Zfish   311 ----PPTQSPSTNQ------------NHGTVIQVTLVKHERSEALGIKLIRKSEEPGVFILDLLP 359

  Fly   424 ------SSKAREQ---LNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLR- 478
                  ..|.|..   |..||..|:.|               :.:.|.:||...:.|:|.||:|
Zfish   360 GGLAAKDGKLRNNDKVLGINGQDLRHG---------------TPESAAQIIQASEMRVNFVVMRL 409

  Fly   479 -DITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPP 542
             |::.:          ....|:.|   |...|:.......:..:::|  |||.|...:.:.::..
Zfish   410 QDVSEE----------GGEGQSRG---ARRVPEPQYFRRHSEYMKEP--PGGFSSQEKTVTLKKE 459

  Fly   543 TRTSNGPNINGNGLNDEKSNLTPRGRSRGPI-----------------MDGVSLQQL--DRPVTP 588
            .|.|.|..|.|.  .|.:|.|.....|..|:                 ::|:.|..|  :..||.
Zfish   460 PRQSLGITIAGG--RDCRSRLPVYITSVQPVGCLHRDGTVKTGDVLLSINGIDLTHLTYNEAVTV 522

  Fly   589 TRGRSA------------AIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEE--------RQSAEP 633
            .:.::|            |.||     ...|.||  ::||..:......::        |....|
Zfish   523 LKTQTAQSTVTLRVIQTFADDE-----EQDGESG--SREDMDTMEGPKDDDINWVPLWTRWLGLP 580

  Fly   634 ------RFISFQKEGSV--GIRLTGGNEAG-----IFVTAVQPGSPASLQG-LMPGDKILKVNDM 684
                  |.|...|..|.  |..:.||.|..     .|:..:.||:||...| |..||:|:.||.:
Zfish   581 SCIHWCRDIMLMKTNSESWGFSIVGGYEESRGQQPFFIKTIVPGTPAYFDGRLKCGDEIVAVNGV 645

  Fly   685 DMNGVTREEAVLFLLSLQDRIDLIV 709
            ...|:.....:..|...::::.|.|
Zfish   646 TTVGMNNSSLIPMLKLQKNKVTLTV 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	24/93 (26%)
		PDZ_signaling	396..477	CDD:238492	21/96 (22%)
		PDZ_signaling	633..710	CDD:238492	25/91 (27%)
		SH3_ZO	729..790	CDD:212793
		GuKc	831..1007	CDD:214504
		ZU5	2263..2351	CDD:279170
lnx2b	NP_998105.2	RING	46..82	CDD:214546
		PDZ_signaling	210..291	CDD:238492	22/85 (26%)
		PDZ_signaling	325..406	CDD:238492	20/95 (21%)
		PDZ_signaling	451..537	CDD:238492	16/87 (18%)
		PDZ_signaling	587..671	CDD:238492	24/84 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910