DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and pdzd8

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_021328830.1	Gene:	pdzd8 / 561279	ZFINID:	ZDB-GENE-110310-2	Length:	1180	Species:	Danio rerio

Alignment Length:	988	Identity:	182/988 - (18%)
Similarity:	288/988 - (29%)	Gaps:	433/988 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 ANGDP-SIAVSDVLKGGPAE-DRLQVNDRIISVNGVSLENVEYATAVQV---LRDSGNTVQLVVK 334
            ::||. .:::..|....||. ..||..||:|::.||.:     .::|||   |:.:|..|.::.:
Zfish   394 SDGDTVHVSIETVTPNSPAALADLQRGDRLIAIGGVKV-----TSSVQVPKLLKQAGERVIVLYE 453

  Fly   335 RRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSLNSSLVQNASSGQPIKV 399
            |.|               .|.:.:.||      |:....:..:.:|:.|          .||
Zfish   454 RPV---------------RHHVPTGGL------GMLQETLGPMEEPSYL----------PQP--- 484

  Fly   400 TLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKI 464
                ||.::|...:                                        .||.:.| .|.
Zfish   485 ----GGYEEDPAPI----------------------------------------TTMDISE-NKD 504

  Fly   465 IDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGG 529
            .|...|.||      :.::||.:.:.::.......|.|    ..|:     .:..||..| |...
Zfish   505 NDSEFEELN------VESKTAAAPVTIDTKEDFLLSVN----QSPK-----KTVANLAKP-LGSI 553

  Fly   530 ASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVS-LQQLDRPVTPTRGRS 593
            :...::.|.:|.|.:|.                  |:...:.|.:.... .:|..||..|
Zfish   554 SPILNRRLNLQSPLKTQ------------------PKESPKPPTLKNAEPSEQPQRPTVP----- 595

  Fly   594 AAIDEPPRPP-----PPR-----GSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGIRL 648
                 ||.||     |||     .|:...||.....:...:.:..:..:|.
Zfish   596 -----PPPPPARPPVPPRPHIKVTSASSEAQSLVEGNEPTVEKSPEKTQPN-------------- 641

  Fly   649 TGGNEAGIFVTAVQPGSPASL-QGLMPGDKILKV---NDMDMNGVTREEAVLFLLSLQDRIDLIV 709
            ||..|..:....|:|..|..: :...|.:.||.:   |..|              |.:|:|....
Zfish   642 TGNGEKPVEKIPVKPPEPKPVSKHPEPTEDILNIPATNKQD--------------SAKDKISESS 692

  Fly   710 QYCKEEYDE----------------------VVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVF 752
            ...::..||                      |:.....:...:.....|.||      ||.|.:.
Zfish   693 SNTRDSVDEQGLWESSETMYRNRTARWNKASVIFEVESNHKFLNVALWCKNP------FKLGSLL 751

  Fly   753 RVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELA-------TAQFNATKKEMNANESR 810
            .:                   ||..:         |.|.||       :|::.:|.: :.|.|.|
Zfish   752 CL-------------------GHVSL---------RLEHLALECISTSSAEYQSTFR-LCAPEPR 787

  Fly   811 GNFFR---RRRSTHR---------------------------------RSKSLSRENWDD----- 834
            .:..|   |..|||:                                 |..||..|:..|
Zfish   788 ASVSRTALRSLSTHKGFNEKLCYGDVTLNFTYLADGESDLSSGLMERERKGSLQEEDLKDREKER 852

  Fly   835 ----VV------------------FSDSISKFPAY----------------------------ER 849
                :|                  |.|:..:.|.|                            |:
Zfish   853 EQVLMVTRDEPIYSGMQIGEMRHNFQDTQFQNPTYCEYCKKKVWTKAASQCMICSYVCHKKCQEK 917

  Fly   850 VVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPLQDDDKSAATSGKCRIV-----RLSNIR 909
            .:|.||..|           .|.:|...| |:..||      .:.||:|..|.:     ||.|:|
Zfish   918 CLLEHPYCV-----------AASDRRGAD-PEAKST------INRATTGLTRHIINTSSRLLNLR 964

  Fly   910 ---------DVMDRG--------KHALLDITPNAVDR---------------------------- 929
                     .|.|.|        ||     |||..|.
Zfish   965 QVPKARLAEQVADMGSGVVEPSPKH-----TPNTSDNESSDTETYTGASPSKQPAGSSGSKLVRK 1024

  Fly   930 ---LNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSD 991
               |:.:.|..|        |.:.:.|..|||  ..:.|:||.....||::..........:||.
Zfish  1025 EGGLDDSVFIAV--------KEIGRDLYRGLP--TDERSQKLELMLDKLQQEIDQELEHNNSLST 1079

  Fly   992 EESWYRKLRDSIDLQQSGAVWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLS 1056
            ||      ||:||.::...:..:.:|..|.|.     .:|...:.|.:..| |||.....|.|..
Zfish  1080 EE------RDTIDSRRKTLITAALAKSGERLQ-----ALTLLMIHYRAGIE-DLESVESTSPSEQ 1132

  Fly  1057 LGNLPQLVKASSD 1069
            .|    ..||.|:
Zfish  1133 HG----FPKAKSE 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	18/63 (29%)
		PDZ_signaling	396..477	CDD:238492	12/80 (15%)
		PDZ_signaling	633..710	CDD:238492	15/80 (19%)
		SH3_ZO	729..790	CDD:212793	9/60 (15%)
		GuKc	831..1007	CDD:214504	55/283 (19%)
		ZU5	2263..2351	CDD:279170
pdzd8	XP_021328830.1	PDZ_signaling	371..453	CDD:238492	18/63 (29%)
		DegQ	<403..551	CDD:333159	45/247 (18%)
		C1	875..917	CDD:237996	4/41 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910