DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and Mpp2

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_001343253.1	Gene:	Mpp2 / 50997	MGIID:	1858257	Length:	569	Species:	Mus musculus

Alignment Length:	447	Identity:	85/447 - (19%)
Similarity:	177/447 - (39%)	Gaps:	112/447 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   644 VGIRLTGGNEAGI---------FVTAVQPGSPASLQGLM-PGDKILKVNDMDMNGVTREEAVLFL 698
            ||||.|.|...|:         .:..:..|...:.|||: .||.|.:||...:....|
Mouse   158 VGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPR------- 215

  Fly   699 LSLQDRI-----DLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCD------NPSK-GEMAFKAGDV 751
             :||:.:     .:|::......:..:..|    ..:|.||..|      :|.| ..:.|.|||:
Mouse   216 -ALQELLRSASGSVILKILPSYQEPHLPRQ----VFVKCHFDYDPARDSLSPCKEAGLRFNAGDL 275

  Fly   752 FRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFF-- 814
            .:::   :......||...:..|    ..|:||::...|:...    ..|:::....:.|...
Mouse   276 LQIV---NQDDANWWQACHVEGG----SAGLIPSQLLEEKRKA----FVKRDLELTPTSGTLCGS 329

  Fly   815 ----RRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERL 875
                :::|..:..:|:...:..:.::: :.:::.|.:.|         :.:||.| ...:.|..|
Mouse   330 LSGKKKKRMMYLTTKNAEFDRHELLIY-EEVARMPPFRR---------KTLVLIG-AQGVGRRSL 383

  Fly   876 AKDF----PDKFSTPL-------QDDDK-----SAATSGKCRI-------------------VRL 905
            ....    ||::.|.:       :|.::     |..:.|:...                   .|:
Mouse   384 KNKLILWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADIRAGRYLEHGEYEGNLYGTRI 448

  Fly   906 SNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSS----- 965
            .:||.|:..||..:||:.|.||..|..|:|.|.|:|::......::.:.    :||.:|.
Mouse   449 DSIRGVVASGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDYETLRAMN----RAALESGVSTKQ 509

  Fly   966 ------KKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSES 1016
                  ::.:|:..:::|.:.|.|...:..|:.|..:|:|:.:::..::...|:..|
Mouse   510 LTEADLRRTVEESSRIQRGYGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQWVPVS 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492	20/80 (25%)
		SH3_ZO	729..790	CDD:212793	16/67 (24%)
		GuKc	831..1007	CDD:214504	41/221 (19%)
		ZU5	2263..2351	CDD:279170
Mpp2	NP_001343253.1	L27	30..83	CDD:197794
		L27	85..136	CDD:308467
		PDZ_signaling	155..233	CDD:238492	20/82 (24%)
		SH3_MPP2	246..304	CDD:212970	16/64 (25%)
		GuKc	376..557	CDD:214504	36/184 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910