DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyd and magi1b

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:XP_005155886.1 Gene:magi1b / 474349 ZFINID:ZDB-GENE-030131-5110 Length:1625 Species:Danio rerio


Alignment Length:1953 Identity:359/1953 - (18%)
Similarity:571/1953 - (29%) Gaps:759/1953 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 PPKSNVYNPLVRYRPTAYVRNGIIGGAEGPGSSGVYQIADRVYTTSKMFLRDGYMYPRQPGQTMD 78
            |.:.:...||......||..||           .||.|.....|||       ::.||    .:|
Zfish   293 PTEEDPLGPLPENWEMAYTENG-----------EVYFIDHNTKTTS-------WIDPR----CLD 335

  Fly    79 -PRFPLE-------LH--------EFPQQFGATGLQLVSAP------------KVHIAGEYLASE 115
             |:.|||       :|        |.|     ||.:.:..|            |.......|.::
Zfish   336 KPQKPLEECEDDEGVHTEELDNELELP-----TGWEKIDDPVYGVYYVDHINRKTQYENPILEAK 395

  Fly   116 QQQQQQQQQQQHQQVQEQQQLGRRKAAAAAEINLANQVYWLGKQKTRSRSRSNSVGNRSITSCMG 180
            :::|.:|.|....:...|:.:....:.|......||.      |:|                 ..
Zfish   396 RKKQLEQSQPAEGERFIQEWIDEHSSGAPLASYAANH------QET-----------------YR 437

  Fly   181 GGGGGGEKERERGGDRDRPYI-RNVDDLLQALGKRDGGDNNSNLLETASTHSSSQRRRFKKGDRT 244
            ..|.|.....:.|..|.:|:. ||..:|            ....:.|          :.||..| 
Zfish   438 DPGTGPPLPTQLGAKRGKPFFTRNPAEL------------KGTFINT----------KLKKSRR- 479

  Fly   245 TWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPA--EDRLQVNDRIISVNG 307
                           |||..|.|| |.|     |..:.:..::..|||  :.:::..|.|:|||.
Zfish   480 ---------------GFGFTVVGG-DEP-----DEFLQIKSLVLDGPAALDGKMETGDVIVSVND 523

  Fly   308 VSLENVEYATAVQVLRD--SGNTVQLVVKRRVPL--------------------NPINAAGAVQH 350
            ..:....:|..|::.:.  .|:.|.|.:.|..||                    .||...|...:
Zfish   524 TCVLGYTHAQVVKIFQSIPIGSMVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGKESY 588

  Fly   351 ----QHSHSLSSVGLMANGSGGVAPTPITSLSQPNSLNSSLVQNASSGQP--------------- 396
                .|....::.|...|||        :...:|:|.::.:..|.|.|.|               
Zfish   589 DSPSSHGSETTAGGSSLNGS--------SDPPRPHSPSAEVASNGSHGYPSDVVTLASSIATQPE 645

  Fly   397 -IKVTLTKGGKKDDYGVVL-------GCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCG 453
             |.|.:.||.|  .:|..:       |.|  ||:|....|.:      .|:|||||..::..|  
Zfish   646 LITVHMEKGDK--GFGFTIADSPSGGGQR--VKQIVDYPRCR------GLREGDIIMEVNKRN-- 698

  Fly   454 DTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSN 518
                                   ::::|:...|..|                      |.|    
Zfish   699 -----------------------VQNLTHNQVVDLL----------------------SKC---- 714

  Fly   519 NNLEDPYLPGGASYSSQNLYVQ---PPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQ 580
                    |.|   |...:.||   .|.:.|            .|.....|..|:|.....||.|
Zfish   715 --------PKG---SEVTMLVQRGVAPAKKS------------PKLQQLERKDSQGSSQHSVSSQ 756

  Fly   581 QLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQE--------------DFYSSRRQLYEER--Q 629
            :.....:|.....|.::|...||||........|:              ..::..|.:||.|  .
Zfish   757 RSIHTDSPLHASQALLNESAAPPPPSQPLPSLPQDPPVDGTLQKKPDPFKIWAQSRSMYESRLPD 821

  Fly   630 SAEPRFISFQKEGSVGIRLTGGNEAG--IFVTAVQPGSPASLQG-LMPGDKILKVNDMDMNGVTR 691
            ..|.....::|:...|.|:.||||.|  |::..:.....|...| |..||:::.|:...:.|.:.
Zfish   822 YQEQDIFLWRKDTGFGFRILGGNEPGEPIYIGHIVKYGAADEDGRLRSGDELICVDGTAVVGKSH 886

  Fly   692 EEAVLFL--LSLQDRIDLIVQ----YCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGD 750
            :..|..:  .:.|..::|.|:    |...:.|..:......|.|..|    ..||..|.......
Zfish   887 QLVVQLMQQAAKQGHVNLTVRRKTGYGLAKVDGEMPPSPASSHHSST----QAPSLTEEKRTPQG 947

  Fly   751 VFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFR 815
            ....::|:.:| .||...:..|.|... ...||||       |...::.   |:...|:.|..| 
Zfish   948 SQNSLNTVSSG-SGSTSGIGSGGGGGS-NNTVIPN-------AILPYDV---EIQRGENEGFGF- 999

  Fly   816 RRRSTHRRSKSLSRENWDDVVFSDSISK------FPAYERVVLRHPGFVRPVVLFGPVSDLARER 874
                                |...|:|:      |.....|.:.|.  :..::...|.     :|
Zfish  1000 --------------------VIVSSVSRPEAGTTFAGNACVAMPHK--IGRIIEGSPA-----DR 1037

  Fly   875 LAKDFPDKFSTPLQDDDKSAATSGKCRIVRLSN---IRDVMDRGKHALLDITPNAVDRLNYAQFY 936
            ..|         |:..|:..|.:| |.|...|:   :..:.:.|....|.|.|            
Zfish  1038 CGK---------LKVGDRILAVNG-CSITNKSHSDIVNLIKEAGNTVTLRIIP------------ 1080

  Fly   937 PVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRD 1001
                                   ....|:..||...:|:..:.:                    .
Zfish  1081 -----------------------GDESSNASLLTNAEKIATITT--------------------T 1102

  Fly  1002 SIDLQQSGAVWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKA 1066
            ....||:.....:.:||.:. |.:|..|.                 :|.|.|             
Zfish  1103 HTPQQQAAPEPRNNTKPKQE-SFEFKAPQ-----------------APPPPA------------- 1136

  Fly  1067 SSDPSIATNQD----NLDRDRDIIGEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQ 1127
               |:.::|||    ::|.:||..|.|.            .....|...||     :|...    
Zfish  1137 ---PTQSSNQDAEFYSVDLERDNKGFGF------------SLRGGREYNMD-----LYVLR---- 1177

  Fly  1128 QQQPGVGGDTAAVRPQSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRNGTLGRSAQERLFGKA 1192
                 :..|.||||                :.:.:.||..|..:|.|::.....|:.:       
Zfish  1178 -----LAEDGAAVR----------------NGKMRVGDEILEINGESTKGMKHARAIE------- 1214

  Fly  1193 VVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLERQARLNAQLKANGVGAGGGGASTYD 1257
                           |:.:|.           ::.|..|.|                |.|     
Zfish  1215 ---------------LIKNGG-----------RKVHLVLRR----------------GDG----- 1232

  Fly  1258 SVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRPLPPTGQSHEYGRTPHDHRSFGGPNDL 1322
            ||..||..|:.    ..|| .|.....::.|.| ...||.||:..|:    .|..|:|....|..
Zfish  1233 SVPEYDGINDG----NGLG-AGAQTVSEVNSAP-PESRPHPPSESSY----PPDLHKSSRNDNKR 1287

  Fly  1323 NRQSSPGRPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRKPLVETKTDYGKYSRNNSVTQADYT 1387
            .|:|.. |.|.|..|...| :.|:.:|::.|.                                 
Zfish  1288 TRESGQ-REHGHRSNHRHN-NHRHRSPEKKSR--------------------------------- 1317

  Fly  1388 KLPKTAPHGVVPPPNVSNGQGQMNGSGTPSSNGSGPFKPVPPPKPKNYRPPVQSGGSSGSGGTTP 1452
                            |.|.|:.:|:.                  |::|                
Zfish  1318 ----------------SKGHGKDSGTS------------------KSHR---------------- 1332

  Fly  1453 WENGDSGSPRSPNGFYYPPTPSHHHYGQQATPGSPSNGHMQ-PPPPQQQQPTYGGSNGNYGQAPP 1516
             :.||.....:.:        ||||:...:...:..:.|.| ...|::::....|...:      
Zfish  1333 -KKGDKKKSSTDD--------SHHHHHHHSNSRNQYHHHRQRHRSPERRRTRSAGDTLD------ 1382

  Fly  1517 PQSYPQANGYNGNGHHYNGGS---GTGPYIAPHRG---MPPPIGNLPPH-TPERHALDLAGSREQ 1574
             ..:.|.||.:.:..|:...|   .:.|:.:|||.   ...|..|..|: :|:|       ||.|
Zfish  1383 -SRHTQRNGRSPDRRHHRHSSPRRHSSPHRSPHRSGYRRSSPYRNRSPYRSPQR-------SRYQ 1439

  Fly  1575 RGSAFELYRKPQIGATAGHHHNMSEMEPYDERYDDYYNMPPPAAHPSQGHHMQRSRSAP---RYP 1636
            ..|     |:|            ::.| :|...|.....|||...||      ||.|.|   |..
Zfish  1440 SPS-----RRP------------TDKE-FDRGIDVTLKEPPPPKPPS------RSESIPLLDRLS 1480

  Fly  1637 HERPPHAQDPNYYGHYGTSRGHSQPRQQYSQHHQQQYYDDHGLEMGPPPLPPHKKKKSVLKSPLV 1701
            .|.....:.|:|      .|..|...:.|                          ::|.|     
Zfish  1481 LEDTVMREPPSY------RRDLSPMERAY--------------------------RESTL----- 1508

  Fly  1702 ALKNALLKSTRPLRRMNSMVEPERKPKGLRRQQSMLERGVQRPYYPDEYPTYPAGFEERAHGG-- 1764
             |:.|....|.|..|........|....|.|.:|.:..|.:...|..:.....:.:..|:.|.  
Zfish  1509 -LRGASRDGTFPRVRTPESDSAFRNYNSLLRGRSPVRVGNRHDAYRRDQSPVASSYRTRSLGRDL 1572

  Fly  1765 ---QGMMQPHSQDAYYQRGGHYAPQQQEMMNSTYQNLEGEDIYGNIGNTVPRMPHHQDNGYGYDQ 1826
               :|......::...|...:|:|.:..              |....|.||. |..  |.|....
Zfish  1573 SPIRGFRDEEEEEVESQLSEYYSPLRSN--------------YSRANNNVPE-PRR--NAYRESP 1620

  Fly  1827 YDL 1829
            .||
Zfish  1621 KDL 1623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 22/88 (25%)
PDZ_signaling 396..477 CDD:238492 20/103 (19%)
PDZ_signaling 633..710 CDD:238492 19/81 (23%)
SH3_ZO 729..790 CDD:212793 15/60 (25%)
GuKc 831..1007 CDD:214504 24/184 (13%)
ZU5 2263..2351 CDD:279170
magi1bXP_005155886.1 PDZ_signaling 17..95 CDD:238492
NK 117..>242 CDD:302627
WW 301..332 CDD:197736 12/48 (25%)
WW 361..390 CDD:278809 5/33 (15%)
PDZ 473..554 CDD:214570 25/102 (25%)
PDZ 645..727 CDD:214570 29/153 (19%)
MAGI_u5 726..818 CDD:293271 20/103 (19%)
PDZ_signaling 832..907 CDD:238492 19/74 (26%)
PDZ_signaling 984..1079 CDD:238492 22/135 (16%)
PDZ_signaling 1150..1228 CDD:238492 23/152 (15%)
DUF1777 1353..>1456 CDD:285811 26/134 (19%)
PRP38_assoc 1369..1453 CDD:289628 24/115 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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