DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and AgaP_AGAP004018

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_001231159.3	Gene:	AgaP_AGAP004018 / 4577298	VectorBaseID:	AGAP004018	Length:	721	Species:	Anopheles gambiae

Alignment Length:	908	Identity:	175/908 - (19%)
Similarity:	281/908 - (30%)	Gaps:	317/908 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   645 GIRLTGGNE--AGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDL 707
            |..:.||.|  .|.||:|::..|.|..|||..||:|::||...:......|...|:.: |:|:
Mosquito    81 GFSIRGGLEYGTGFFVSAIERDSEADRQGLKVGDQIIRVNGYQVEDAVHRELAQFIAN-QERL-- 142

  Fly   708 IVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIG 772
                        :...||               .|.:..|.    |..|.|      :|.|:..|
Mosquito   143 ------------IMKVRG---------------LGILPIKE----RTADPL------TWHVVSFG 170

  Fly   773 RGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRRRSTHRRSKSLSRENWDDVVF 837
            ....:....::.......::......|.:.::.....:|                  .:|...:|
Mosquito   171 MSRDKQDALLLEEPCGGRDVKVILSVAPRTKLGCGICKG------------------PDWKPGIF 217

  Fly   838 SDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPLQDDDKSAATSGKCRI 902
                                    |.|.....:|||           ..|:..|:..:.:|
Mosquito   218 ------------------------VQFTKEGGVARE-----------AGLRPGDQILSCNG---- 243

  Fly   903 VRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKK 967
                          |:..:.|           |...|..:|  |.||::.:..  |.|.
Mosquito   244 --------------HSFAEAT-----------FGEAVAVMK--SSHVLELVVR--PSAG------ 273

  Fly   968 LLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSESKPVESLSDDFLFPMTT 1032
                   |:           ....|.|.|.....|::..||.......||.:..:.::   .:|.
Mosquito   274 -------LD-----------LFPGESSGYNSSASSVNGDQSPCWGDQTSKRLSIVREE---SITH 317

  Fly  1033 SRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSDPSIATNQDNLDRDRDIIGEGLPPPYTVP 1097
            .|...|::|               :..:|::..||...|                 |:||| ..|
Mosquito   318 DRRRLAAAP---------------VATVPEMPPASDSKS-----------------GVPPP-PPP 349

  Fly  1098 YDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQ--PG---VGGDT--------------AAVRPQ 1143
            .....|.:.:.:|.....:          ||||  |.   .||.|              |.|.|:
Mosquito   350 QPQQQPHHQDEQQVQQQQQ----------QQQQLTPRGTLAGGATRRKNTTIIEFSERGAIVNPE 404

  Fly  1144 SLYGINAPDLPPRIDRQSKPGDIPLNTSG-SSSRNGTLGRSAQERLFGKAVVQDDVQAEYITRNA 1207
            :... ....:...:.|.:..|.:..:.:| .::..||: ......||...|.....|:   ..||
Mosquito   405 AKQS-ETKTIIVEVHRSASAGSMVDDETGHGAAAAGTI-IPPPPPLFADTVTTSSGQS---VTNA 464

  Fly  1208 LVGSGAAETLDRQQQQQQQTHASLER----QARLNAQLKANGVGAGGGGASTYDSVSSYDSYNNT 1268
            ...| ::.||.::|......|.||..    :.|..||.||   ...||||:        |.....
Mosquito   465 AAAS-SSTTLAQEQASAAAAHHSLSNAISDELRRRAQKKA---APAGGGAT--------DPATGP 517

  Fly  1269 QMAMQNLGRLGPNAPDDLKSVPNANGRPLP-------PTGQSHEYGRTPHDHRSF--GGPN-DLN 1323
            ..|:..|       .:.||. .|...||:.       .|....|: |..| .|.|  |..| :|.
Mosquito   518 AAALTEL-------ENRLKE-KNVRLRPVTMAISDERHTALMDEF-RAVH-KRMFKNGFDNAELK 572

  Fly  1324 RQSSPGRPHYHDMNASRNI-DPRNGTPQRPSNLGLESSPRKPLVE-TKTDYGKYSRNNSVTQA-D 1385
            :||    |..:|.:..:.| |..||..      |...||:..:.. ..::..|.|.:::..:: :
Mosquito   573 KQS----PKTNDADHGQPIQDAVNGAS------GARKSPKGTMGRVAASEMAKASGDSAELESIE 627

  Fly  1386 YTKL--PKTAPHGVVPPPNVSNGQGQMNGSGTPSSNGSGPFKPVPPPKPKNYRP-PVQSGGSSGS 1447
            ..||  |:..|   |.||:.         ...|.:.|       ||...|:.:| .|.....:.|
Mosquito   628 SFKLNNPQQPP---VRPPSY---------YFCPQATG-------PPTMKKSQKPIAVTISEYATS 673

  Fly  1448 GGTTPWENGDSGSPRSPNGFYYPPTPSHHHYGQQAT------PGSPSNGHMQPPPPQQQQ-PT 1503
            .|.|.       .|:....|         .:||..:      .|.|..|..:.|..:|:| ||
Mosquito   674 AGRTE-------EPKKTTRF---------DFGQLRSVTEAIGGGGPVGGPKEGPLSRQRQAPT 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492	22/66 (33%)
		SH3_ZO	729..790	CDD:212793	8/60 (13%)
		GuKc	831..1007	CDD:214504	25/175 (14%)
		ZU5	2263..2351	CDD:279170
AgaP_AGAP004018	XP_001231159.3	PDZ_signaling	56..147	CDD:238492	22/80 (28%)
AgaP_AGAP004018	XP_001231159.3	PDZ_signaling	192..269	CDD:238492	20/160 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910