DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and tjp2b

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_001002366.1	Gene:	tjp2b / 436639	ZFINID:	ZDB-GENE-040718-58	Length:	371	Species:	Danio rerio

Alignment Length:	358	Identity:	103/358 - (28%)
Similarity:	144/358 - (40%)	Gaps:	128/358 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 HSSSQRRRFKKGDRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAED 294
            |.||..      :.|.||.:||.:.|....|||||||||||||:..:|:.||.|||||.||||:.
Zfish     7 HQSSGM------EETVWEQYTVTLQRDAKMGFGIAVSGGRDNPNVESGETSIIVSDVLPGGPADG 65

  Fly   295 RLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKR------------------------ 335
            .|..|||:|.||.:::.||.::.|||.||..|...::.|||
Zfish    66 LLFENDRVIQVNTIAMNNVPHSFAVQSLRKCGKVAKITVKRPRSVHSDPDSDYPRGNGGLGYPRD 130

  Fly   336 ----------RVPL------------------------NPINAAG-------------------A 347
                      |:..                        :|...:|                   .
Zfish   131 RERDRSLDKSRIDYLDPDYRSQDYDSRRERSRGRSTDRSPSTDSGYRRDGSRGRTLERGSSPEPR 195

  Fly   348 VQHQHSHSLSSVGLMANGSGGVAPTPITSLSQP-------------NSLNSSLVQNASSG----- 394
            .|.|||          .|.||.:|....|..|.             .|.:...:|:.|..
Zfish   196 YQRQHS----------RGRGGGSPAGSYSRDQGYDTRRYDTQDRMIRSHSRDRLQDHSPSPSRER 250

  Fly   395 -------------QPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITR 446
                         .|:.|||.|....::||:.||.::|:||::|..   |.|...:|||||||.:
Zfish   251 DRGRDRFNYEPLEPPVNVTLVKNRPNEEYGLRLGSQIFIKEMTSTG---LAARDGNLQEGDIILK 312

  Fly   447 IHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRD 479
            |:.| ..:.:||.:|.|:|:..:.:|.|||.||
Zfish   313 INGT-VTENLSLSDAGKLIEKSRGKLQLVVQRD 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	43/84 (51%)
		PDZ_signaling	396..477	CDD:238492	32/80 (40%)
		PDZ_signaling	633..710	CDD:238492
		SH3_ZO	729..790	CDD:212793
		GuKc	831..1007	CDD:214504
		ZU5	2263..2351	CDD:279170
tjp2b	NP_001002366.1	PDZ_signaling	20..105	CDD:238492	43/84 (51%)
tjp2b	NP_001002366.1	PDZ_signaling	265..342	CDD:238492	32/80 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590011
Domainoid	1	1.000	113	1.000	Domainoid score	I6090
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175136at2759
OrthoFinder	1	1.000	-	-		FOG0001438
OrthoInspector	1	1.000	-	-		otm25454
orthoMCL	1	0.900	-	-		OOG6_103390
Panther	1	1.100	-	-	O	PTHR13865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3326
SonicParanoid	1	1.000	-	-		X1692
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.880