DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and MPP3

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_001317162.1	Gene:	MPP3 / 4356	HGNCID:	7221	Length:	610	Species:	Homo sapiens

Alignment Length:	570	Identity:	104/570 - (18%)
Similarity:	189/570 - (33%)	Gaps:	183/570 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   557 NDEKSNL----TPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDF 617
            :||:..|    ||..|:...:.|.|:.:..|               |..||.|..     ..|||
Human   111 SDERELLQLLSTPHLRAVLMVHDTVAQKNFD---------------PVLPPLPDN-----IDEDF 155

  Fly   618 YSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLM-PGDKILKV 681
            .....::....::.||...:.:::...|         .:.|..:..|..|...||: .||::.:|
Human   156 DEESVKIVRLVKNKEPLGATIRRDEHSG---------AVVVARIMRGGAADRSGLVHVGDELREV 211

  Fly   682 NDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEM-- 744
            |.:.:.....:|....|...|..|.|.:....:|.|.:    :.....::..||. ||.:...
Human   212 NGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRL----KESKVFMRALFHY-NPREDRAIP 271

  Fly   745 AFKAGDVF---RVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNA 806
            ..:||..|   :|::.:.......||..::  |...::.|:||:|.
Human   272 CQEAGLPFQRRQVLEVVSQDDPTWWQAKRV--GDTNLRAGLIPSKG------------------- 315

  Fly   807 NESRGNFFRRRRSTHRRS-------KSLSRENWDDVVFSDSIS---------------------- 842
                   |:.||.::||:       :||.:..:|.....::..
Human   316 -------FQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLGCR 373

  Fly   843 ------------------KFPAYERVV-LRHPGFVRP--VVLFGPVSDLARE---RLAKDFPDKF 883
                              :...||.|. .:|....||  |||.|.:.....|   ::..:.|..|
Human   374 ERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHF 438

  Fly   884 -------STPLQDDDKSA-------------------------------ATSGKCRIVRLSNIRD 910
                   :.|.:..:|..                               .||       |..|:.
Human   439 GVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTS-------LEAIQA 496

  Fly   911 VMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLP--KAAHKSSKKLLEQCQ 973
            ||.:.|..|:|:.|.|:.:|..::|.|.:||:|.    .|::.|...|  .|...::....||.|
Human   497 VMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKP----AIQEKRKTPPMSPACEDTAAPFDEQQQ 557

  Fly   974 K-------LERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSES 1016
            :       ::|.:.|:....:...|.:..|.:|:..::.......|:..|
Human   558 EMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVS 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492	16/77 (21%)
		SH3_ZO	729..790	CDD:212793	15/65 (23%)
		GuKc	831..1007	CDD:214504	45/268 (17%)
		ZU5	2263..2351	CDD:279170
MPP3	NP_001317162.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910