DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and dlg4b

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_999893.1	Gene:	dlg4b / 405796	ZFINID:	ZDB-GENE-040628-3	Length:	801	Species:	Danio rerio

Alignment Length:	849	Identity:	201/849 - (23%)
Similarity:	315/849 - (37%)	Gaps:	285/849 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 EYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPA--EDRLQVNDRIISVNGVS 309
            ||..:.:.| ...|.|.:::||.||||..: ||||.::.::.||.|  :.||:|||.|:.||.|.
Zfish   150 EYEEITLER-GNSGLGFSIAGGTDNPHIGD-DPSIFITKIIPGGAAAQDGRLRVNDSILFVNDVD 212

  Fly   310 LENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPI 374
            :..|.::.||:.|:::|..|:|.|.|                |..|...:            |.:
Zfish   213 VREVTHSFAVEALKEAGPIVRLYVLR----------------HKPSAEKI------------TEL 249

  Fly   375 TSLSQPNSLNSSLV-----QNASSGQPIKVT-LTKGGKKDDYGVVLGCRLFVKEISSKAREQLNA 433
            ..:..|..|..|:.     |:......|.|| :.:||.....|     ||   :|..|.   |..
Zfish   250 KLIKGPKGLGFSIAGGVGNQHVPGDNSIYVTKIIEGGAAHKDG-----RL---QIGDKI---LAV 303

  Fly   434 NGYSLQE---GDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSA 495
            |...|:|   .|.:..:.||  ||.:.|:.||.:
Zfish   304 NNMYLEEVMHEDAVAALKNT--GDVVFLRVAKTL------------------------------- 335

  Fly   496 SHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEK 560
                       ||                       :..|:.|..|...:|..|:::   ::|..
Zfish   336 -----------HQ-----------------------HHHQDAYNPPDITSSYSPHMD---MSDYP 363

  Fly   561 SNLTPRG-RSRGPIMDGVSL-QQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQ 623
            ..|:|.. |...||..|:.| ..:.|             ||.|....|||:|
Zfish   364 QALSPSSPRRYSPIPKGLFLDDDISR-------------EPRRVVIHRGSTG------------- 402

  Fly   624 LYEERQSAEPRFISFQKEGSVGIRLTGGNEA-GIFVTAVQPGSPASLQG-LMPGDKILKVNDMDM 686
                                :|..:.||.:. |||::.:..|..|.|.| |..||:||.||.:|:
Zfish   403 --------------------LGFNIVGGEDGEGIFISFILAGGAADLSGELRKGDQILSVNGVDL 447

  Fly   687 NGVTREEAVLFLLSLQDRIDLIVQYCKEEYD----------EVVTN----------QRGD-SFHI 730
            ...|.|:|...|.:....:.:|.||..|||.          |.:.|          :.|. ||.|
Zfish   448 RHATHEQAAAALKNAGQTVTIITQYRPEEYSRFEAKIHDLREQLMNSSLVSAAASLRSGKRSFFI 512

  Fly   731 KTHFHCDNPSKG-----EMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQR-GVIPNKSRA 789
            :..|..|..:.|     .::|:.|||.:|.|....   ..||..|:. .|.|::. |.||:|.|.
Zfish   513 RALFDYDKTADGGFLSQAVSFRFGDVLQVFDCSDE---EWWQAGKLA-PHGELEETGYIPSKRRV 573

  Fly   790 EELATAQFNATKKEMNANESRGNFFRRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRH 854
            |          :||.:..::||     |.....||        |.:|         :||.|....
Zfish   574 E----------RKEWSRLKTRG-----REPVSGRS--------DYIV---------SYETVTQSE 606

  Fly   855 PGFVRPVVLFGPVSDLARERLAKDFPDKFST--------------------------PLQDDDKS 893
            ..:.|||::.||..|...:.|..:|||||.:                          .::.|.:|
Zfish   607 VHYARPVIILGPSKDRVNDDLLSEFPDKFGSCVPHTTRPKREYEMDGRDYHFVSSREQMEKDIQS 671

  Fly   894 -------------AATSGKCRIVRLSNIRDVMD-RGKHALLDITPNAVDRLNYAQFYPVVIFLKT 944
                         ..||       :.::|.|.: :|||.:||::.|||.||..||.||:.||::.
Zfish   672 HRFIEAGQYNSHLYGTS-------VQSVRQVAEQQGKHCILDVSANAVRRLQAAQLYPIAIFIRP 729

  Fly   945 DSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSG 1009
            .|...:..:...|   ..:.:::.|::..|||:.:...||..:.....|..|..::..|:.|...
Zfish   730 SSLQNVLNISKRL---TEEQARRALDRAVKLEQDFIECFSAIVEGESFEEIYHHVKSVIEEQSGP 791

  Fly  1010 AVWM 1013
            .:|:
Zfish   792 YIWI 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	32/86 (37%)
		PDZ_signaling	396..477	CDD:238492	22/84 (26%)
		PDZ_signaling	633..710	CDD:238492	23/78 (29%)
		SH3_ZO	729..790	CDD:212793	20/66 (30%)
		GuKc	831..1007	CDD:214504	50/215 (23%)
		ZU5	2263..2351	CDD:279170
dlg4b	NP_999893.1	L27_1	4..58	CDD:286187
		MAGUK_N_PEST	71..152	CDD:287565	1/1 (100%)
		PDZ	153..237	CDD:278991	32/85 (38%)
		PDZ	245..331	CDD:214570	25/110 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..373		8/36 (22%)
		PDZ_assoc	342..392	CDD:287558	14/65 (22%)
		PDZ_signaling	391..471	CDD:238492	29/112 (26%)
		SH3	509..574	CDD:302595	22/68 (32%)
		Guanylate_kin	609..788	CDD:279019	45/188 (24%)
		GuKc	617..788	CDD:214504	42/180 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910