DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and pals2a

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_001243118.1	Gene:	pals2a / 402878	ZFINID:	ZDB-GENE-050506-35	Length:	550	Species:	Danio rerio

Alignment Length:	666	Identity:	119/666 - (17%)
Similarity:	229/666 - (34%)	Gaps:	223/666 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   447 IHNTNCGDTMSLKEAKKIIDGCKE--------RLNLVVLRDITNQTAVSQLNLNNSASHQASGNI 503
            :.|...|..|     ::::|..||        .::|:.||.|
Zfish     3 VSNAKSGTAM-----QQVLDNLKELPPSTGAKDIDLIFLRGI----------------------- 39

  Fly   504 YATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLND---------- 558
              ...|.|...:.::..|||..|..          ||     ||...:....|:|
Zfish    40 --MESPIVRSLAKAHERLEDVKLEA----------VQ-----SNNVELVSEILSDMSSLIIRDES 87

  Fly   559 --EKSNL--TPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYS 619
              |.||:  .|..:|.....|.|:.:..:.|.|.|...|.             ||......|
Zfish    88 AAELSNILKEPHFQSLLEAHDKVASKSYEAPPTSTNSTSM-------------SSSSLMPAD--- 136

  Fly   620 SRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLM-PGDKILKVND 683
            :.|.:..::::.||..::|:.|           |..:.:..|..||....||:: .||.|.:||.
Zfish   137 TVRMISIQKKAGEPLGVTFRVE-----------EGDLVIARVLHGSMIDRQGMLHAGDVIREVNG 190

  Fly   684 MDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDSF---------HIKTHFHCDNP 739
            .::.                :..:.:|:...:.:..:|.:...|:         ::|.||:. ||
Zfish   191 REVG----------------KDPMALQHMLRDCNGSITLKILPSYKDTPPPAQVYLKPHFNY-NP 238

  Fly   740 S--------KGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQ 796
            :        :..:||..||:..::   :......||...|..||    .|:||          :|
Zfish   239 NTDNLIPCREAGLAFSKGDILHIV---NKEDPNWWQACNINGGH----TGLIP----------SQ 286

  Fly   797 FNATKKEMNANESRGNFFRRRRS---------THRRSKS----LSRENWD----DVVFSDSISKF 844
            |        ..|.|..|.||...         |.::.|.    |:.:|.:    ::...:.::|.
Zfish   287 F--------LEEKRKAFVRRDLDGSGILCGTLTGKKKKKKMMYLTAKNAEFDRHELQIYEEVAKM 343

  Fly   845 PAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDF----PDKFSTPL-------QDDDKSAAT-- 896
            |.::|         :.:||.| ...:.|..|....    |.::.|.:       :||:|...:
Zfish   344 PPFQR---------KTLVLIG-AQGVGRRSLKNRLIVLNPLRYGTTVPFTSRRPRDDEKDGQSYC 398

  Fly   897 ----------------------SGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVV 939
                                  .|.....::.:|.:|:..|:..:||:.|.|:..|..::|.|.|
Zfish   399 FVSREEMEMDIKASRYLEHGEYDGNLYGTKMDSIHEVVRAGRTCILDVNPQALKVLKTSEFMPFV 463

  Fly   940 IFLKTDSKHVIKQLRHGLPKA-------AHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYR 997
            :|:.......::.:...:..|       .....||.:::..:::|.::|.|...|...:.:..:.
Zfish   464 VFIAAPELDTLRAMHKAVVDAGITTKLLTETDLKKTVDESARIKRAYNHYFDLTIVNDNLDKAFE 528

  Fly   998 KLRDSIDLQQSGAVWM 1013
            ||:.:::...:...|:
Zfish   529 KLQAAVEQLTTQPQWV 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492	7/37 (19%)
		PDZ_signaling	633..710	CDD:238492	14/77 (18%)
		SH3_ZO	729..790	CDD:212793	17/68 (25%)
		GuKc	831..1007	CDD:214504	36/221 (16%)
		ZU5	2263..2351	CDD:279170
pals2a	NP_001243118.1	L27	13..66	CDD:197794	15/92 (16%)
		L27	68..119	CDD:308467	9/50 (18%)
		PDZ_signaling	138..216	CDD:238492	18/104 (17%)
		SH3_MPP	229..286	CDD:212796	17/74 (23%)
		Guanylate_kin	347..537	CDD:331880	33/199 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910