DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and sirt6

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_989353.1	Gene:	sirt6 / 394980	XenbaseID:	XB-GENE-5929105	Length:	331	Species:	Xenopus tropicalis

Alignment Length:	347	Identity:	64/347 - (18%)
Similarity:	113/347 - (32%)	Gaps:	102/347 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   864 FGPVSDLAR------ERLAKDFPDKFSTPLQDDDKSAATSGKCRIVRL---SNIRDVMDRGKHAL 919
            |.|..:|.|      :.:.|.....|.|       .|..|..|.|...   :.:..:.::|.:..
Frog    24 FDPPDELCRKVVELADMIRKSSYVVFHT-------GAGISTSCGIPDFRGPNGVWTLEEKGVNPK 81

  Fly   920 LDIT-----PN----AVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPK--AAHKSSKKLLEQCQ 973
            .|||     |:    |:.:|........::....|..||    |.|.|:  .|.......:|:|.
Frog    82 FDITFESACPSPTHMALLQLQRVGILKFLVSQNVDGLHV----RSGFPREQLAELHGNMFVEECS 142

  Fly   974 KLERVWSHIFSTQIALSDEESWYRKLRDSI-------------DLQQSGAVWMSESKPVESLSD- 1024
            |..:.:                   :||.:             |:.:...:.....|..:::.|
Frog   143 KCSKQY-------------------VRDQVVGTMGLKPTGRLCDVPKVRGLRACRGKLKDTILDW 188

  Fly  1025 -DFLFPMTTSRLSYASSPESDLELSPGPSASL-SLGNLPQLVKASSDPSIATNQDNLDRDR---- 1083
             |.| |.....|:..:..::||.::.|.|..: ..||||.|.|......:..|......|:
Frog   189 EDSL-PDRDLNLADEACRKADLSITLGTSLQIRPSGNLPLLTKRKGGKLVIVNLQPTKHDKHADL 252

  Fly  1084 --------------DIIGEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGVG 1134
                          :::|..:|....:| ....|.|.|.::.......|:.|.|  |.|::.|..
Frog   253 RIHGYVDEVMTQLMELLGHKIPVWTGMP-TKTEPTNGNYKEENHFYNDSVLGAN--PNQKREGCK 314

  Fly  1135 GDTAAVRPQSLYGINAPDLPPR 1156
            .:              |:|.|:
Frog   315 EE--------------PNLEPK 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492
		SH3_ZO	729..790	CDD:212793
		GuKc	831..1007	CDD:214504	31/175 (18%)
		ZU5	2263..2351	CDD:279170
sirt6	NP_989353.1	SIRT7	45..257	CDD:238701	44/242 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165172895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930