DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and tjp3

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_001315269.1	Gene:	tjp3 / 373089	ZFINID:	ZDB-GENE-030828-10	Length:	1255	Species:	Danio rerio

Alignment Length:	1272	Identity:	349/1272 - (27%)
Similarity:	529/1272 - (41%)	Gaps:	385/1272 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 DRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVN 306
            :.|.||.|||.:::....|||.|||||.|.|:.||||.::.||||:..|||..|||..|:|:.||
Zfish     3 EMTIWEQHTVTLSKDSKVGFGFAVSGGLDKPNPANGDAAVVVSDVIPTGPAMGRLQTRDQIVMVN 67

  Fly   307 GVSLENVEYATAVQVLRDSGNTVQLVVKR----RVPLNPINAAGAVQHQHSHSLSSVGLMANGSG 367
            |||:|||.....:|.||..|.|..:.|||    ::|.:......|.|   |:.|...|....|..
Zfish    68 GVSMENVTSLYTIQNLRKCGKTANITVKRPRTIQIPASSRPTRSASQ---SNILDDKGPQYKGQR 129

  Fly   368 G-----------VAP------TPITSLSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLG 415
            |           |.|      .|||  |....|.:..|||    :|||.||.|....|:||:.||
Zfish   130 GPDTTRTRRARSVTPDRNGHDLPIT--SGYKRLPNQDVQN----KPIKTTLIKKKPTDEYGMKLG 188

  Fly   416 CRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRD- 479
            .::|:|.::...   |.|...||||||::.:| |....:.:||.|.|.:::..:..|.::||||
Zfish   189 SQIFIKHMTPTG---LAAKEGSLQEGDLVLKI-NGMTTENLSLLETKHLVEKSRGNLTMLVLRDD 249

  Fly   480 ----------------------------------------ITNQT-------------------- 484
                                                    :||:.
Zfish   250 RKFLVSIPEVEDSPQNSSDERREDSSSELEEISDLDSDLPVTNRASRRKDRKSNRNRADPVSKKL 314

  Fly   485 ----------------------AVSQLNLNNS-------ASHQ---ASGNIYAT-HQPQVSGCSS 516
                                  :.|:.:.:||       ..|:   .||  |:| ..|:.|..:|
Zfish   315 ESPPLRSTLTRPAQSMPPRRVPSESESDRSNSPPPRHDTLDHRNKVLSG--YSTLPNPRASPITS 377

  Fly   517 SNNN---------------------------------------------------------LEDP 524
            |:.:                                                         :..|
Zfish   378 SSTSRPRRAVSESDSDRSASPPPRRESPRPDNHSRYKVLPDLPPPGLKPSSLSMSQDFPRRMASP 442

  Fly   525 YLP---------------------GGASYSSQNLY-----------VQPP------TRTSNGPNI 551
            |.|                     ..||..|:|.|           ::||      |.....|:
Zfish   443 YRPPPRDASESESDESARPQRRQGTPASQESRNRYRAAPEVKAAAVMEPPKWAKPSTPVQRAPS- 506

  Fly   552 NGNGLNDEKSNLTPR---------GRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRG 607
              ...:|...|..|:         .|.:||        ::..|:|..|........|.||||...
Zfish   507 --ESESDGSYNSPPKQPPSPVSKSSRIKGP--------EMQMPITSIRQDPPLRAAPARPPPEDS 561

  Fly   608 SSGGAAQ-----EDFYSS----------------------------RRQLYEERQSAEP------ 633
            |....||     .|.::|                            ...||.....|.|
Zfish   562 SDSERAQSPLRRSDSHNSDHSFPRANGTLRSNVSIPNHTALTSKAVEEPLYVLPPDAVPTPNLGY 626

  Fly   634 ----RFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEA 694
                ..|||.||||||:||.|||:.||||..|||.|||..||:..||:||:||.||.|..|||||
Zfish   627 SSDQNHISFVKEGSVGLRLVGGNDVGIFVGGVQPNSPAQKQGITEGDQILEVNGMDFNHFTREEA 691

  Fly   695 VLFLLSLQ--DRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHF-HCDNPSKGEMAFKAGDVFRVID 756
            .::|::::  :|||:..|...:.|.:::.:..||||:|:||: |..:.|.| ::|..|:||||:|
Zfish   692 AMYLMNIRGGERIDMRTQNKADIYKKILKSNLGDSFYIRTHYDHVADSSVG-LSFTRGEVFRVVD 755

  Fly   757 TLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELAT---AQFNATKKEMNANESRGNFFRRRR 818
            |:|.|.:|:|..:::|....|:.:|.|||::|||.||.   || ..:..|..|:..|..|::.|.
Zfish   756 TMHRGKLGTWLAVRMGNDLHELDKGTIPNQTRAETLANLEQAQ-RISAAERQASGPRAEFWKLRG 819

  Fly   819 STHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKF 883
            .  |.:|..:|...||::......||||||:|:|:...|.||:|:.||::|:|.|:||::.||:|
Zfish   820 L--RGAKKSNRRTRDDLLQLTIQGKFPAYEKVLLKEANFKRPIVILGPLNDIANEKLARELPDEF 882

  Fly   884 S----TPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKT 944
            .    .|...:|.|::      :::|..:|.:.::.||.||||||.|::||||.|::|:|:||..
Zfish   883 EIAEMVPRSGNDSSSS------VIKLDTVRRIAEQDKHPLLDITPTAIERLNYIQYHPMVLFLDP 941

  Fly   945 DSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALS-DEESWYRKLRDSIDLQQS 1008
            .|:..:|.:|......:.|||::|..|..||.:.:|.:||.:|.|. :...||..|:|.|..|||
Zfish   942 HSRKDVKSMRQKYMPGSSKSSRRLYAQALKLRKNYSTLFSARIDLQPNTNMWYDVLKDKIRQQQS 1006

  Fly  1009 GAVWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSDPSIA 1073
            ..||:|| ..:|..:::.|.....:..|...|..||.|.:.|              :|.:|....
Zfish  1007 KPVWVSE-VAMEGGAEEDLDAFNRANNSDYLSGASDYEDTDG--------------EAFTDGEAY 1056

  Fly  1074 TNQDNLD------------------RDRDIIGEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSIY 1120
            |:.::|:                  ....::.....|||            |..:..:..:|::.
Zfish  1057 TDNEDLEEPLGGIAKHRSSALARSSEPASVLNHSPEPPY------------NLHEEEEEPEYTLP 1109

  Fly  1121 GTNVPPQQQQP---------GVGGDTAAVRPQSLY--------GINAP----DLPPRIDRQSKPG 1164
            .:.|||....|         |:..:...|..|..:        .:.||    |.||:. |...|.
Zfish  1110 PSEVPPILHVPEPRSPRLVAGIPEEQEDVPSQRSFTDSDFSNDDVVAPQTPSDAPPKF-RAPDPK 1173

  Fly  1165 DIPLNTSGSSSRNGTLGRSAQERLFGKAVVQDDVQAE 1201
            |:...|...|        :.:||| .:|.:.:.::.|
Zfish  1174 DVQSKTPPLS--------AIEERL-QQARMAEQIEPE 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	42/84 (50%)
		PDZ_signaling	396..477	CDD:238492	28/80 (35%)
		PDZ_signaling	633..710	CDD:238492	45/88 (51%)
		SH3_ZO	729..790	CDD:212793	25/61 (41%)
		GuKc	831..1007	CDD:214504	67/180 (37%)
		ZU5	2263..2351	CDD:279170
tjp3	NP_001315269.1	PDZ_signaling	10..95	CDD:238492	42/84 (50%)
		PDZ_signaling	170..246	CDD:238492	27/79 (34%)
		Rubella_Capsid	444..>565	CDD:283420	25/131 (19%)
		PDZ	632..700	CDD:278991	41/67 (61%)
		DegQ	<652..704	CDD:223343	27/51 (53%)
		SH3	725..789	CDD:302595	28/64 (44%)
		NK	831..1005	CDD:302627	67/179 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590013
Domainoid	1	1.000	83	1.000	Domainoid score	I8313
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175136at2759
OrthoFinder	1	1.000	-	-		FOG0001438
OrthoInspector	1	1.000	-	-		otm25454
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13865
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.950