DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and metro

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	99/500 - (19%)
Similarity:	191/500 - (38%)	Gaps:	128/500 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   613 AQEDFY----SSRRQLYEERQ---------SAEPRFISFQKEGSVGIRLTGGNEAG-IFVTAVQP 663
            ||:|||    .:..::.|:.:         |.||...:...|..||..:....|:| |.:..:..
  Fly   117 AQKDFYPHLPEAPVEMDEDEETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMH 181

  Fly   664 GSPASLQGLM-PGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDS 727
            |..|...||: .||::::||::::.|.|..:.:..|.:.:..|...:.....:     ..||...
  Fly   182 GGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNK-----GAQRESK 241

  Fly   728 FHIKTHFHCDNP--------SKGEMAFKAGDVFRVI--DTLHNGVVGSWQVLKIGRGHQEMQR-G 781
            ..::.||.. ||        .:..:||:.|||..::  |..:     .||..|   .|:...| |
  Fly   242 VRVRAHFDY-NPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAY-----WWQARK---EHERSARAG 297

  Fly   782 VIPNKSRAEELA---TAQFNAT------------------KKEMNANESRGNFFRRRRSTHRRSK 825
            :||:::..|...   ..|.|.|                  ...:.|:.|        .|:.|:.|
  Fly   298 LIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSS--------TSSCRQPK 354

  Fly   826 SLSRENWDDVVFSDSISK--FPAYERV--VLRHPGFVRPVVLFGPV----SDLARERLAKDFPDK 882
              :::...|:..:|...:  ...||.|  :...||..||:||.|..    ::|.|..:|:| |:|
  Fly   355 --TKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVFRPIVLIGAPGVGRNELRRRLIARD-PEK 416

  Fly   883 FSTPL------------------------QDDDKSAAT-------SGKCRIVRLSNIRDVMDRGK 916
            |.:|:                        .|.|..|..       .|........:::.:::.|.
  Fly   417 FRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGC 481

  Fly   917 HALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSS--------------KK 967
            ..:|.....|:..|..||..|.:|.:|.....::|..|   .:|..||:              :.
  Fly   482 VCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATR---TEARAKSTFDEANARSFTDEEFED 543

  Fly   968 LLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVW 1012
            :::..::::.::.|.|..::...:..:.:.:|..::...::..||
  Fly   544 MIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVW 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492	19/78 (24%)
		SH3_ZO	729..790	CDD:212793	18/71 (25%)
		GuKc	831..1007	CDD:214504	41/228 (18%)
		ZU5	2263..2351	CDD:279170
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794	5/9 (56%)
		PDZ_signaling	139..229	CDD:238492	21/89 (24%)
		SH3_MPP	243..302	CDD:212796	18/67 (27%)
		Guanylate_kin	390..575	CDD:279019	33/188 (18%)
		GuKc	399..580	CDD:214504	29/184 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910