DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and apba2b

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_005168985.1	Gene:	apba2b / 327160	ZFINID:	ZDB-GENE-030131-5371	Length:	834	Species:	Danio rerio

Alignment Length:	846	Identity:	167/846 - (19%)
Similarity:	263/846 - (31%)	Gaps:	320/846 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1239 AQLKANGVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRPLPPTGQS 1303
            ||.|..|:.:|                    ||.:      |:||     .|.:...|.|.....
Zfish     2 AQRKRPGINSG--------------------MATE------PHAP-----APRSCPAPYPDPEHP 35

  Fly  1304 HEYGRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRP--SNLGLESSPRKPLV 1366
            .|.....||       .::.:.|      ||:...:...|.|..||..|  ::....|.|.....
Zfish    36 EEEYEEHHD-------PEVTQHS------YHNQEEADLTDSRPTTPTTPDHAHRDYHSHPDSLDG 87

  Fly  1367 ETKTDYGKYSRNNSVTQADYTK-LPKTAPHGVV------------------PPPNVSNGQGQMNG 1412
            ::.:||  .:..:...:.|:.: ||: ...||.                  ..|...:..|:|.
Zfish    88 DSSSDY--VNNTSDEEEDDFDEGLPE-EDEGVTYYIRYCPEDDSYLEGMDCNDPEYVHPDGRME- 148

  Fly  1413 SGTPSSNGSGPFKPVPPPKPKNYRPPVQ--------SGGSSGSGGTTPWENGDSGSPR------- 1462
                           |||.....:..|:        :.|..........::.|.|..|
Zfish   149 ---------------PPPDTDECQEAVEEWVEGEDDAQGDEDDDDEEEDDDDDDGEVRCEVLEQD 198

  Fly  1463 SPNGFY---YPPTPSHHHYGQQATPGSPSNGHMQ--PPPPQQQQPTYGGSNGNYGQAPPPQSYPQ 1522
            |....|   ..|...|||:.....|      |.:  |||.:.|:.....|:..|  .|..:..||
Zfish   199 SDQQLYDGRPEPVLDHHHHQHYTDP------HQEQLPPPIEDQEVKDVESSERY--CPDQEEEPQ 255

  Fly  1523 A----NGYNGNGHHYNGGSGTGPYIAPHRG------------------------MPPPIGNLPPH 1559
            .    .||.|: ::....:|.....:|:||                        |...:|:|...
Zfish   256 VGRDREGYAGD-YYATEDNGNSVRASPYRGHKGTEGETGEEAEEDIDQIVAEIKMSMSMGSLSSG 319

  Fly  1560 T---PERHALDLAGSREQRGSAFELYRKPQIGATAGHHHNMSEMEPYDERYD---DYYNMPPPAA 1618
            |   ||..|.|.|.|    |...|...||: .|.|.:        |...|:|   ...|:||...
Zfish   320 TDQSPEELAPDPAPS----GYQPETRSKPE-PAPAPY--------PQPHRHDGRPKSLNIPPARH 371

  Fly  1619 HPSQGHHMQRS-RSAPRYPHERPPHAQDPNYYGHYGTSRGHSQPRQQYSQHHQQQYYDDHGLEMG 1682
            :|    .:||: :..|..|.:|....||              |.|:|.|...:|
Zfish   372 NP----ELQRNFKVRPHTPEDRQRWTQD--------------QVREQMSNGAEQ----------- 407

  Fly  1683 PPPLPPHKKKKSVLKSPLVALKNALLKSTRPLRRMNSMV------EP------------------ 1723
                 |.|:::|.|..||.  .|.:.:.|:......|.|      ||
Zfish   408 -----PRKQQRSDLNGPLE--NNNVTEPTKKTASFPSFVDVPGPCEPEDLIDGIIFAANYLGSTQ 465

  Fly  1724 ---ERKP-KGLRRQQ-----SMLERGVQRPYYPDEYPTYPAGFEERAHGGQGMMQPHSQ-DAYY- 1777
               ||.| |.:|..|     |.::| ||:          .|..:::|...:|..|..:: |.:.
Zfish   466 LLSERNPSKNIRMMQAQEAVSRVKR-VQK----------AAKIKKKAQSPEGDAQTLTEVDLFIS 519

  Fly  1778 -QR-GGHYAPQQQEMMNSTYQNLEGEDIYGNIGNTV-----PRMPHHQDNGYGYDQYDLYANRAC 1835
             || ....|..|:.||::..:.:   ....:|||.|     .|||.             .|::.|
Zfish   520 TQRIKVLNADTQETMMDNALRTI---SYIADIGNIVVLMARRRMPR-------------TASQDC 568

  Fly  1836 IDLERRQAEAAAASGGRNGRRIVRRHSTTTADRGGNPGPP----RRPMISPGYE-QDPQEIYQTR 1895
            |:                          ||      ||.|    :..||...:| :|.|.|.|:.
Zfish   569 IE--------------------------TT------PGAPEAKKQYKMICHVFESEDAQLIAQSI 601

  Fly  1896 NGAYML-------------PDQRRAPSSEVMTRRRFYPGAANEQTEEEPLYQSRREMQREMQRNH 1947
            ..|:.:             .|..:...|:::..:..|    |:.........:.:|:|.|.|:..
Zfish   602 GQAFSVAYQEFLRANGINPEDLSQKEYSDIINTQEMY----NDDLIHFSNSDNCKELQLEKQKGE 662

  Fly  1948 L 1948
            :
Zfish   663 I 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492
		SH3_ZO	729..790	CDD:212793
		GuKc	831..1007	CDD:214504
		ZU5	2263..2351	CDD:279170
apba2b	XP_005168985.1	PTB_X11	447..620	CDD:269919	45/231 (19%)
		PDZ	653..734	CDD:278991	4/11 (36%)
		PDZ	746..817	CDD:278991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910