DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and baz

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster

Alignment Length:	1714	Identity:	342/1714 - (19%)
Similarity:	519/1714 - (30%)	Gaps:	665/1714 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 AEGPGSSGVYQIADRVYTTSKMFLRDGYMYPRQPGQTMDPRFPLELHEFPQQFGATGLQLVSAPK 104
            |.|..|||.:|...|....|..||.||..|     :.|:
  Fly   241 ANGGSSSGNHQPFARSGRLSMQFLGDGNGY-----KWME-------------------------- 274

  Fly   105 VHIAGEYLASEQQQQQQQQQQQHQQVQEQQQLGRRKAAAAAEI-NLANQVYWLGKQKTRSRSRS- 167
                    |:|:.|.|...||.:||.......|:..|.::..: ..:.:...||:.....|.:.
  Fly   275 --------AAEKLQNQPPAQQTYQQGSHHAGHGQNGAYSSKSLPRESKRKEPLGQAYESIREKDG 331

  Fly   168 ------NSVGN-RSITSCMGGGGGGG--EKERERGGDRDRPYIRNVDDLLQALGKRDGGDNNSNL 223
                  |..|: ..:|:......|||  .:..|.|...:|..:|..|.:|:..|.:..|...|.:
  Fly   332 EMLLIINEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQV 396

  Fly   224 LE--TASTHSSSQRRRFKKGDRT-----------TWEYHTVAVTRVP------------------ 257
            .|  ..:..||..|.|..:|||.           ..|..||:.||.|
  Fly   397 QEQLRRALESSELRVRVLRGDRNRRQQRDSKVAEMVEVATVSPTRKPHAAPVGTSLQVANTRKLG 461

  Fly   258 ------------GYGFGIAVSGGRDNPHFANGDPSIAVSDVL-KGGPAED-RLQVNDRIISVNGV 308
                        |.||.:..   ||||  |.|...|.:.::| :|...|| ||:..||::.|:|.
  Fly   462 RKIEIMLKKGPNGLGFSVTT---RDNP--AGGHCPIYIKNILPRGAAIEDGRLKPGDRLLEVDGT 521

  Fly   309 SLENVEYATAVQVLR--DSGNTVQLVVKRRVPL-----NPINAAGAVQHQHSHSLSSVGLMANGS 366
            .:........|.:||  .:|.||::||.|:..|     .|...:..|....|.:..:|...|
  Fly   522 PMTGKTQTDVVAILRGMPAGATVRIVVSRQQELAEQADQPAEKSAGVAVAPSVAPPAVPAAA--- 583

  Fly   367 GGVAPTPITSLSQPNSL-------------------------NSSLVQNASSGQ---------PI 397
            ....|.|:...|...||                         |.||..:::|..         |:
  Fly   584 APAPPIPVQKSSSARSLFTHQQQSQLNESQHFIDAGSESAASNDSLPPSSNSWHSREELTLHIPV 648

  Fly   398 KVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAK 462
            ..|     :|...||         .:..|....|||:|.|...|......|:.:.|..:     |
  Fly   649 HDT-----EKAGLGV---------SVKGKTCSNLNASGSSASSGSNGLMKHDGDLGIFV-----K 694

  Fly   463 KIIDG----------CKERL---NLVVLRDITNQTAVSQLN---LNNSASHQASGNIYATHQPQV 511
            .:|.|          ..::|   |.|.||...|..|:..|.   :|....|  .|.|......::
  Fly   695 NVIHGGAASRDGRLRMNDQLLSVNGVSLRGQNNAEAMETLRRAMVNTPGKH--PGTITLLVGRKI 757

  Fly   512 SGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSN------------LT 564
            ...:||::.|:.   ....|:|..|        :|.|.|.||:|.|:..|:            |:
  Fly   758 LRSASSSDILDH---SNSHSHSHSN--------SSGGSNSNGSGNNNNSSSNASDNSGATVIYLS 811

  Fly   565 PR-----------GRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFY 618
            |.           |.|.|..|:..|...|||   .|.|..::....|       ||..:.|:..:
  Fly   812 PEKREQRCNGGGGGGSAGNEMNRWSNPVLDR---LTGGICSSNSAQP-------SSQQSHQQQPH 866

  Fly   619 SSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVND 683
            .|::|..:.|..|.|..      .|..:|    ||: .::......|||.:.
  Fly   867 PSQQQQQQRRLPAAPVC------SSAALR----NES-YYMATNDNWSPAQMH------------- 907

  Fly   684 MDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKA 748
                          |::......|:::...|.....:..:..|..|..|  ...|||:.......
  Fly   908 --------------LMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNT--SSANPSQNLAVGNQ 956

  Fly   749 GDVFRVI----DTLHN--GVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNAN 807
            |.....:    .|..|  ....|...|:...|.:...|..:..:|.:|:...|        ::|.
  Fly   957 GPPINTVPGTPSTSSNFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAA--------LDAR 1013

  Fly   808 ESRGNFFRRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLAR 872
            |:         .|::|:|.| ||                 ||...|.....:..|..|.:..|.
  Fly  1014 ET---------GTYQRNKKL-RE-----------------ERERERRIQLTKSAVYGGSIESLT- 1050

  Fly   873 ERLAKDFPDKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYP 937
            .|:|              ..:|..||.                |||
  Fly  1051 ARIA--------------SANAQFSGY----------------KHA------------------- 1066

  Fly   938 VVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDS 1002
                 ||.|.                     :||.:..:         |:|.::.|:     ||.
  Fly  1067 -----KTASS---------------------IEQRETQQ---------QLAAAEAEA-----RDQ 1091

  Fly  1003 I-DLQQSGAVWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSL--------- 1057
            : ||..|  :.|.:|..:|||                .:...:|::|..|....:|
  Fly  1092 LGDLGPS--LGMKKSSSLESL----------------QTMVQELQMSDEPRGHQALRAPRGRGRE 1138

  Fly  1058 GNLPQLVKASSDPSIATNQDNLDRDRDIIGEGLPPPYTVPYDH----AVPANPNRRQTMDSSKYS 1118
            .:|...|.:..|.|       ..|...::.:|         ||    |...|...:.:::..|:.
  Fly  1139 DSLRAAVVSEPDAS-------KPRKTWLLEDG---------DHEGGFASQRNGPFQSSLNDGKHG 1187

  Fly  1119 IYGTNVPPQQQQPGVGGDTAAVRPQSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRNGTLGRS 1183
            ...:.               |.:|..|.||....   |..:..|.|.:|:
  Fly  1188 CKSSR---------------AKKPSILRGIGHMF---RFGKNRKDGVVPV--------------- 1219

  Fly  1184 AQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTH-----------ASLERQARL 1237
                        |:.........::|.:..:..|.:|||||.|.|           |:|||..:.
  Fly  1220 ------------DNYAVNISPPTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALAALERNGKP 1272

  Fly  1238 NA-----QLKA-NGVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRP 1296
            .|     .|.| ||||:.|        :...|.:|:......|.        :||.
  Fly  1273 PAYQPPPPLPAPNGVGSNG--------IHQNDIFNHRYQHYANY--------EDLH--------- 1312

  Fly  1297 LPPTGQSHEYGRTPHDHRSFGGPNDLN------------------RQ------SSPGRPHYHDMN 1337
                 |.|:      .|:..||.:..:                  ||      .|....|||...
  Fly  1313 -----QQHQ------QHQISGGDSTTSISETLSESTLECMRQQVIRQRIKVEAESRRHQHYHSQR 1366

  Fly  1338 ASRNID-----PRNGT-------PQRPSNLGLESSPRKPLVETKTDYG------KYSRNNSVTQA 1384
            ::|:.|     ..:|:       ||..|| |:.  |.....|.:|...      |:|.::|.|.:
  Fly  1367 SARSQDVSMHSTSSGSQPGSLAQPQAQSN-GVR--PMSSYYEYETVQQQRVGSIKHSHSSSATSS 1428

  Fly  1385 DYTKLPKTAPHGVVPPPNVSNGQGQMNGSGTPSSNGS----GPFKPVPPPKPKNYRPPVQSGGSS 1445
              :..|...||...         ..|||....|.|.|    |||......:.::
  Fly  1429 --SSSPINVPHWKA---------AAMNGYSPASLNSSARSRGPFVTQVTIREQS----------- 1471

  Fly  1446 GSGGTTPWENGDSGSPRSPNGFYYPPTPSH---HHYGQQATPGSPSNGHMQPPPPQQQQPTY--- 1504
             |||                      .|:|   .|..||.               |||||||
  Fly  1472 -SGG----------------------IPAHLLQQHQQQQL---------------QQQQPTYQTV 1498

  Fly  1505 ----GGSNGNYGQAPPPQSYPQAN 1524
                |.|  .||.|...|  |.|:
  Fly  1499 QKMSGPS--QYGSAAGSQ--PHAS 1518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	32/118 (27%)
		PDZ_signaling	396..477	CDD:238492	20/93 (22%)
		PDZ_signaling	633..710	CDD:238492	10/76 (13%)
		SH3_ZO	729..790	CDD:212793	13/66 (20%)
		GuKc	831..1007	CDD:214504	26/176 (15%)
		ZU5	2263..2351	CDD:279170
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	18/70 (26%)
		CRS1_YhbY	<390..>436	CDD:294440	11/45 (24%)
		PDZ_signaling	462..548	CDD:238492	26/90 (29%)
		PDZ_signaling	<686..753	CDD:238492	16/73 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910