DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and PDZRN4

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_001158067.1	Gene:	PDZRN4 / 29951	HGNCID:	30552	Length:	1036	Species:	Homo sapiens

Alignment Length:	1065	Identity:	209/1065 - (19%)
Similarity:	342/1065 - (32%)	Gaps:	404/1065 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 RSRSR---SNSVGNRSI--------TSCMGGGGG------GGEKERERG-GDRDRPYIRNVDDLL 208
            |.|||   ::.:|...:        |...|.|||      ||...|.|| |.|...:.|....||
Human   111 RLRSRGGCASGLGGGEVPARGGCGPTPRAGRGGGARGGPPGGRWGRGRGPGPRVLAWRRREKALL 175

  Fly   209 QALGKRDGGDNNSNLLETASTHSSSQRRRFKK------------------GDRTTWEY--HTVAV 253
            ..|....|        |...|     .||:::                  |.|...|:  .|:.:
Human   176 AQLWALQG--------EVQLT-----ARRYQEKFTQYMAHVRNFVGDLGGGHRRDGEHKPFTIVL 227

  Fly   254 TRVPGYGFGIAVSGGRDNPHFANGDPS--IAVSDVLKGGPAE--DRLQVNDRIISVNGVSLENVE 314
            .| .....|..:.|||.|.:...|..:  |.||.:|:.|||:  |.|:::|:|:.|||..|....
Human   228 ER-ENDTLGFNIIGGRPNQNNQEGTSTEGIYVSKILENGPADRADGLEIHDKIMEVNGKDLSKAT 291

  Fly   315 YATAVQVLRDSGNTVQLVVKRRVPLNP-----------INAAGAVQHQHSHSLSSVGLMANGSGG 368
            :..||:..|::...:.:.|.||.||:.           :||:........|.::...|.
Human   292 HEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDITFEHIMALAKLR------ 350

  Fly   369 VAPTP--------ITSLS------------QPNSLNSSLVQNASSGQPI---KVTLTKGGKKDDY 410
             .|||        :.|.|            :.|...|||..:|...:..   :|.|.:...::..
Human   351 -PPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKL 414

  Fly   411 GVVLGCR--------LFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKII-- 465
            |:.:..|        ::|.|:...:   :.|....::|||   ||...|..|..:.:||..::
Human   415 GLTVCYRTDDEEDTGIYVSEVDPNS---IAAKDGRIREGD---RILQINGEDVQNREEAVALLSN 473

  Fly   466 DGCKERLNLVV----------LRDITNQTAVSQLNL------NNSASHQASGNIYATHQPQV--- 511
            |.||..:.||.          |.|..|: .:.:|||      :|.|....:..:   .||:.
Human   474 DECKRIVLLVARPEIQLDEGWLEDERNE-FLEELNLEMLEEEHNEAMQPTANEV---EQPKKQEE 534

  Fly   512 ------SGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSR 570
                  :..|||||:.:|    .|...:.::|                  .|||.|
Human   535 EEGTTDTATSSSNNHEKD----SGVGRTDESL------------------RNDESS--------- 568

  Fly   571 GPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRF 635
                               ...:||.|       |..:|        ..|:|.|.:.:.:.
Human   569 -------------------EQENAAED-------PNSTS--------LKSKRDLGQSQDTL---- 595

  Fly   636 ISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLF--L 698
                  |||.::.   ||:                 |:.|:.|    |.|..|...|:...|  |
Human   596 ------GSVELQY---NES-----------------LVSGEYI----DSDCIGNPDEDCERFRQL 630

  Fly   699 LSLQDRIDLIVQY----------CKE------EYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFK 747
            |.|:.:|....:|          |.:      |::..:.|:...:..::    |.|..:.....|
Human   631 LELKCKIRNHGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIELE----CQNIMQAHRLQK 691

  Fly   748 AGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVI------PNKSRAEELA---TAQ------- 796
            ..|.:..|.|||:|...::..      ..:||||.:      |.||..:..:   ||:
Human   692 VTDQYGDIWTLHDGGFRNYNT------SIDMQRGKLDDIMEHPEKSDKDSSSAYNTAESCRSTPL 750

  Fly   797 -------------FNATKKE-----MNANE-SRGNFFRRRRSTHRRS--KSLSRENWDDVVFSDS 840
                         .|.|.|:     |.|.: |.|...:...||..::  :..|.|:.:.|:..
Human   751 TVDRSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKESTSTKAKTTEQGCSAESKEKVLEG-- 813

  Fly   841 ISKFPAYERVVLRHPGFVRP--------------------------------------------- 860
             ||.|..|:.|..|..::.|
Human   814 -SKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHARHYQSYMQLIQQKSAVEYAQSQLSLVSMCK 877

  Fly   861 ----------------------VVLFGPVSD-LARERLAKDFPDKFSTPLQDDDKSAATSG---- 898
                                  .:...||.| :.:||..|...::......||..|....|
Human   878 ESQKCSEPKMEWKVKIRSDGTRYITKRPVRDRILKERALKIKEERSGMTTDDDTMSEMKMGRYWS 942

  Fly   899 ----KCRIVRLS---NIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHG 956
                |..:||..   ..|:.|.|.:...|..:|.:                .::.|..|..:...
Human   943 KEERKQHLVRAKEQRRRREFMMRSRLECLKESPQS----------------GSEGKKEINIIELS 991

  Fly   957 LPKAAHKSSKKLLEQCQKLERVWSH 981
            ..|...|.:||:|:....::.:.:|
Human   992 HKKMMKKRNKKILDNWMTIQELMTH 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	26/88 (30%)
		PDZ_signaling	396..477	CDD:238492	21/103 (20%)
		PDZ_signaling	633..710	CDD:238492	17/78 (22%)
		SH3_ZO	729..790	CDD:212793	16/66 (24%)
		GuKc	831..1007	CDD:214504	34/230 (15%)
		ZU5	2263..2351	CDD:279170
PDZRN4	NP_001158067.1	RING	17..54	CDD:238093
		Sina	66..>108	CDD:302762
		PDZ	221..313	CDD:214570	27/92 (29%)
		PDZ_signaling	402..484	CDD:238492	20/87 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910