DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and CARD10

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_055365.2	Gene:	CARD10 / 29775	HGNCID:	16422	Length:	1032	Species:	Homo sapiens

Alignment Length:	1150	Identity:	229/1150 - (19%)
Similarity:	389/1150 - (33%)	Gaps:	344/1150 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TAYVRN-GIIGGAEGPGSSGVYQIADRVYTTSKM--FLR----DGY---------MYPRQ----P 73
            |.|:|. .:|...:.......|:...||..|.::  .||    .||         .||..    .
Human    48 TPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLT 112

  Fly    74 GQTMDPRFPLELHEFPQQFGATGLQLVSAPKVHIAGEYLASEQQQQQQQQQQ----------QHQ 128
            ||....|..:.|.|    .|..||......:|....|...|:.|::||.|.:          ..|
Human   113 GQEPAQRCSMILDE----EGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQ 173

  Fly   129 QVQEQQQLGRR--------KAAAAAEINLANQVYWLGKQKTRSRSRSNSVGNRS----------- 174
            ::::|||...|        :|.:...:.|.::.|.:..:..:.....||...||
Human   174 RLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLK 238

  Fly   175 ------------ITSCMGGGGGGGEKERERGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETA 227
                        :....|...|..|||:|:..:::...:..|.:|..         .|..|  ||
Human   239 LKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRA---------ENQRL--TA 292

  Fly   228 STHSSSQRRRFKKGDRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGG-- 290
            |.....:                           |:.....|..   |.|...|.: |:|:..
Human   293 SLRELQE---------------------------GLQQEASRPG---APGSERILL-DILEHDWR 326

  Fly   291 PAED-RLQVNDRIISVNGVSLENVE-----YATAVQVLRDSGNTVQL---VVKRRVPL------- 339
            .|:| |.::..::.:|.| .|:..|     |...::.||....|:|.   :.|.|:..
Human   327 EAQDSRQELCQKLHAVQG-ELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEE 390

  Fly   340 ------NPINAAGAVQHQHSHSLSSVGLMANGSGGVAP------TPITSLSQPNSLNSSLVQNAS 392
                  ..|.:...:|.|:|.||...........|:..      |.:|||....:|....:|.|.
Human   391 IEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455

  Fly   393 SGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMS 457
            .|..:|                .|                |:.:||          .:|...|.|
Human   456 GGTCLK----------------AC----------------ASSHSL----------CSNLSSTWS 478

  Fly   458 LKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQ------------PQ 510
            |.|....:.|          .:.|.:.||    :.....|.:.   .||..            |.
Human   479 LSEFPSPLGG----------PEATGEAAV----MGGPEPHNSE---EATDSEKEINRLSILPFPP 526

  Fly   511 VSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMD 575
            .:|........||| .|...|:||.:......|.....|.::.:..:|   ::.|.|:..|.:..
Human   527 SAGSILRRQREEDP-APPKRSFSSMSDITGSVTLKPWSPGLSSSSSSD---SVWPLGKPEGLLAR 587

  Fly   576 GVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQK 640
            |..|..|:        ||.||....|.||     ||                   .||     |.
Human   588 GCGLDFLN--------RSLAIRVSGRSPP-----GG-------------------PEP-----QD 615

  Fly   641 EGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMD---MNGVTREEAVLF----- 697
            :|..|:...|...:|..|..|..| |.|.: :.|.::.::...::   :....::..:|:
Human   616 KGPDGLSFYGDRWSGAVVRRVLSG-PGSAR-MEPREQRVEAAGLEGACLEAEAQQRTLLWNQGST 678

  Fly   698 LLSLQDRIDLIVQYCKEEYDEVVTNQRG---DSFHIKTHFHCDNPSKGE---MAFKAGDVFRVID 756
            |.||.|.     :.|:..::.:....:|   :.|:|:.:...  |.:.:   :..||.::.|::|
Human   679 LPSLMDS-----KACQSFHEALEAWAKGPGAEPFYIRANLTL--PERADPHALCVKAQEILRLVD 736

  Fly   757 TLHNGVVGSWQVLKIG-RGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRG---NFFRRR 817
            :.:.. ...|...::. ...:::.||.:||..||::|...|    :|.:.::..||   |..:|.
Human   737 SAYKR-RQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQ----EKCLPSSRHRGPRSNLKKRA 796

  Fly   818 RSTHR--RSKSLSRENWDDVVFSDSISKFPAYE-RVVLRHPGFVRPVV----------------- 862
            ....|  |.|.:.....|.   .|.:...|..| ...||....|||::
Human   797 LDQLRLVRPKPVGAPAGDS---PDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPR 858

  Fly   863 LFGPVSDLARERLAKDFPDKFSTPLQDDD---KSAATSGKCRIV------RLSNIRDVMDRGKHA 918
            |...:.||...||  ||....:..|..::   .||..:.|.:..      |:..|::.:.: ||.
Human   859 LIRNLLDLPSSRL--DFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGK-KHC 920

  Fly   919 LLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERV----- 978
            ||::....|..|...:.||:||.::...|:| :::|..|.:...:.| :||.||:..|:|
Human   921 LLELGARGVRELVQNEIYPIVIHVEVTEKNV-REVRGLLGRPGWRDS-ELLRQCRGSEQVLWGLP 983

  Fly   979 ----------WSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWM 1013
                      |.|          .|...:.:|..|..:|:..||:
Human   984 CSWVQVPAHEWGH----------AEELAKVVRGRILQEQARLVWV 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	19/95 (20%)
		PDZ_signaling	396..477	CDD:238492	11/80 (14%)
		PDZ_signaling	633..710	CDD:238492	17/84 (20%)
		SH3_ZO	729..790	CDD:212793	12/64 (19%)
		GuKc	831..1007	CDD:214504	48/217 (22%)
		ZU5	2263..2351	CDD:279170
CARD10	NP_055365.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		CARD_CARD10_CARMA3	27..112	CDD:260069	14/63 (22%)
		Tmemb_cc2	<112..245	CDD:287269	27/136 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..276		6/22 (27%)
		ThylakoidFormat	<282..395	CDD:299915	27/155 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..553		17/89 (19%)
		SH3	705..770	CDD:302595	13/67 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910