DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and Tjp1

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_038961189.1	Gene:	Tjp1 / 292994	RGDID:	1306305	Length:	1875	Species:	Rattus norvegicus

Alignment Length:	2335	Identity:	628/2335 - (26%)
Similarity:	952/2335 - (40%)	Gaps:	608/2335 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 RERGGDRDRPYIRNVDDLLQALG------------KR-----DGGDNNSNLLETASTHSSSQRR- 236
            |||.||:.: |.:.:..|..|:|            ||     ...:|........|....|.||
  Rat    20 RERSGDKMK-YQKYLTVLQMAIGVTPSNRGSLLPLKRKLWVTPSSENPHGATSNVSQGKPSLRRI 83

  Fly   237 -----RFKKGD--------------RTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIA 282
                 |.|..|              ...||.|||.:.|.||:|||||:|||||||||.:|:.||.
  Rat    84 KGRLHRSKSLDSIDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIV 148

  Fly   283 VSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRR----VPL---- 339
            :||||||||||.:||.|||:..|||||::|||:|.|||.||.||...::.::|:    :|:
  Rat   149 ISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPD 213

  Fly   340 -NPI--NAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSL----NSSLVQNASSGQPI 397
             :|:  |...:.........|..|.:||..|..:.....|.|:..||    :...|.::...:|.
  Rat   214 PDPVSDNEDDSYDEDVHDPRSGRGALANRRGEKSWARDRSASRDRSLSPRSDRRSVASSQPAKPT 278

  Fly   398 KVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAK 462
            ||||.|..|.::||:.|...:||||||   ::.|.|...::||||::.:|:.| ..:.|||.:||
  Rat   279 KVTLVKSRKNEEYGLRLASHIFVKEIS---QDSLAARDGNIQEGDVVLKINGT-VTENMSLTDAK 339

  Fly   463 KIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSS--SNNNLEDPY 525
            .:|:..|.:|.:||.|| ...|.::..:|::|. |.|:    |:.:..:|...|  |::::....
  Rat   340 TLIERSKGKLKMVVQRD-ERATLLNVPDLSDSI-HSAN----ASERDDISEIQSLASDHSVRSHD 398

  Fly   526 LPGGASYS-SQNLYVQPPTRTSNGPN--INGNGLNDEKSNLTPRGRSRGPI----------MDGV 577
            .|...|.| |.:...:|...::..|.  .||:..:.|:..::..|....|:          ::.|
  Rat   399 RPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAVSTPVKHVDDHTPKAVEEV 463

  Fly   578 SLQQLDRPVTPT----RGRSAAIDEPPRPPPPRGSSG---GAAQEDFYSSRRQLYEERQSAEPRF 635
            ::::.::. |||    :...|.:.:|....|...|.|   .:..||...        |.|.  :.
  Rat   464 TVEKHEKQ-TPTLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGIL--------RPSM--KL 517

  Fly   636 ISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLS 700
            :.|:|..|||:||.|||:.||||..|...|||:.:||..||:||:||::|...:.|||||||||.
  Rat   518 VKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLD 582

  Fly   701 LQ--DRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGVV 763
            |.  :.:.::.|..|:.|..:|.:..||||:|:|||..:..|...::|..|:||||:|||:||.:
  Rat   583 LPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKL 647

  Fly   764 GSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRRRSTHRRSKSLS 828
            |||..::||:.|:|::||::|||:|||:||:.|:...|   .|...|.:|:|.|..  |.||...
  Rat   648 GSWLAIRIGKNHKEVERGIVPNKNRAEQLASVQYTLPK---TAGGDRADFWRFRGL--RSSKRNL 707

  Fly   829 RENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPLQDDDKS 893
            |::.:|:......:|||||||||||..||:|||.:|||::|:|||:||::.||.:.. .:.:.:.
  Rat   708 RKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQI-AKSEPRD 771

  Fly   894 AATSGKCR-IVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGL 957
            |.|..:.. |:||..|:.::|:.||||||:||||||||||||:||:|:||..|||..:|.:|..|
  Rat   772 AGTDHRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRL 836

  Fly   958 PKAAHKSSKKLLEQCQKLERVWSHIFSTQIAL-SDEESWYRKLRDSIDLQQSGAVWMSESKPVES 1021
            ...:.||::||.|:..||.:...|:|:|.|.| |..:.||..|:::|..||:..||:||.|...:
  Rat   837 CPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGA 901

  Fly  1022 LSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSDPSIATNQDNLDRDRDII 1086
            .|||  ..:...||||.|:|.|:..:....|...|     ......::....|:|:..:...|.:
  Rat   902 TSDD--LDLHDDRLSYLSAPGSEYSMYSTDSRHTS-----DYEDTDTEGGAYTDQELDETLNDEV 959

  Fly  1087 GEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGVGGDTAAVRPQSLYGINAP 1151
              |.||...:...    :.|.|.   |||.........||...|         .:||:::.|::|
  Rat   960 --GTPPESAITRS----SEPVRE---DSSGMHHENQTYPPYSPQ---------AQPQAIHRIDSP 1006

  Fly  1152 DLPPRIDRQSKPGDIPLNTSGSSSRNGTLGRSAQERLFGKAVVQDDVQAEYITRNALVGSGAAET 1216
            .|                            ::|.::   ||.....|  .|::......|.|:..
  Rat  1007 GL----------------------------KTASQQ---KAEASSPV--PYLSPETNPASSASAV 1038

  Fly  1217 LDRQQQQQQQTHASLERQARLNAQLKANGVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPN 1281
                :.....|:.:||...                .|.....||..|.          ||...|.
  Rat  1039 ----KHNVNLTNVNLEEPT----------------PAPPTSHVSQADC----------LGAPSPE 1073

  Fly  1282 APDDLKSVPNANGRPLPPTGQSH-----EYGRTPHDHRSFGGPNDLNRQSSPGRPHYH-DMNASR 1340
            ||   .::....|..||    ||     .|.:.|:..... ..|.:.:|.:.|.|... |...:.
  Rat  1074 AP---HTMLRDEGVSLP----SHVDPAKVYRKEPYPEEMM-RQNHILKQPALGHPGQRLDKEPNP 1130

  Fly  1341 NIDPRNGTPQRPSNLGLESSPRKPLVETKTDYGKYSRNNSVTQADYTKLPKTAPHGVVPPPNVSN 1405
            ..||:....::.::..||..|.:....:.||  ::|||..              |.:.....|
  Rat  1131 AYDPQLPYVEKQASRDLEQPPYRYESSSYTD--QFSRNYD--------------HRLRFEDRV-- 1177

  Fly  1406 GQGQMNGSGTPSSNGSGPFKPVPPPKPKNYRPPVQSGGSSGSGGTTPWENGDSGSPRSPNGFYYP 1470
                      |:......:.....|.|                 |.|:   |:..||..:...:|
  Rat  1178 ----------PTYEDQWSYYDDKQPYP-----------------TRPF---DTQHPRDLDSRQHP 1212

  Fly  1471 PTPSHHHYGQQATPGSPSNGHMQPPP-PQQQQPTYGGSNGNYGQAPPPQSYPQANGYNGNGHHYN 1534
            ...|...|.|:         ..:|.| |...:|.|
  Rat  1213 EEASERGYFQR---------FEEPAPLPYDSRPRY------------------------------ 1238

  Fly  1535 GGSGTGPYIAPHRGMPPPIGNLPPHTPERHALDLAGSREQRGSAFELYRKPQIGATAGHHHNMSE 1599
                               ..||..:..||       .||..|.:|:           |:....|
  Rat  1239 -------------------EQLPRTSTLRH-------EEQPTSGYEV-----------HNRYRPE 1266

  Fly  1600 MEPYDERYDDYYNMPPPAAHPSQGHHMQRSRSAPRYPHERPPHAQDPNYYGHYGTSR-GHSQPRQ 1663
            .:||           .||. |......|.....||...:.||    |.:     ||: ||.:|.
  Rat  1267 AQPY-----------APAG-PKSSEPKQYFDQYPRSYEQVPP----PGF-----TSKTGHYEPL- 1309

  Fly  1664 QYSQHHQQQYYDDHGLEMGPPPLPPHKKKKSVLKSPLVALKNALLKSTRPLRRMNSMVEPERKPK 1728
                         ||..:.||.:|..:.|..||.|           :|:|.....::.|.|..|
  Rat  1310 -------------HGAAVVPPLIPSSQHKPEVLPS-----------ATKPQPPPPALTEEEEDP- 1349

  Fly  1729 GLRRQQSMLERGVQRPYYPDEYPTYPAGFEERAHGGQGMMQPHSQDAYYQRGGHYAPQQQEMMNS 1793
             ..:.||:|.|...              ||                                 |.
  Rat  1350 -AMKPQSVLTRVKM--------------FE---------------------------------NK 1366

  Fly  1794 TYQNLEGEDIYGNIGNTVPRMPHHQDNGYGYDQYDLYANRACIDLERRQAEAAAASGGRNGRRIV 1858
            ...:||.:.   ::.:|....|                           .|.|:.
  Rat  1367 RSASLENKK---DVNDTASFKP---------------------------PEVASK---------- 1391

  Fly  1859 RRHSTTTADRGGNPGPPRRPMISPGYEQDPQEIYQTR-----NGAYMLPDQRR---APSSEVMTR 1915
                           ||...::.      |:.:.||:     ...|.||:.::   .|..:::..
  Rat  1392 ---------------PPSASLVG------PKPVSQTQFSEHDKTLYRLPEPQKPQAKPPEDIVRS 1435

  Fly  1916 RRFYPGAANEQTEEEPLYQSRREMQREMQRNHLYQSKREMQERISQGKRDMEREFSPQSSSSQSE 1980
            ..:.|....|...::..|..||..:.:... |:.....      |:..:.:..:..|..||..|:
  Rat  1436 NHYDPEEDEEYYRKQLSYFDRRSFESKPPA-HIPAGHH------SEPAKPVHSQSQPNFSSYSSK 1493

  Fly  1981 ASNSEAIYQ-SRREAKESALKTRSQLRDQIYQTRREALD-SMAEPIYVSKRGMGRPAPIYETREE 2043
            ...|...|. .:|..|....:|             :|:| |.:|..|...:.|..|.|:.....:
  Rat  1494 FLGSYTSYDYLKRNIKWGKPET-------------DAMDRSFSEKRYDPTQAMPPPPPLPSQYSQ 1545

  Fly  2044 SILQSRENETDEKKEKECKTEQIQVEINAQPEEQIEDSTLSRSDLQKSSDTVIENPARAPLVQDE 2108
            .: ....|.:.....|..::|...|.::.|      :|.:|:.|...|.    ..||..
  Rat  1546 PV-PPLSNSSLHIHSKAAQSEGNSVSLDFQ------NSYISKPDPPPSQ----SKPATF------ 1593

  Fly  2109 VDDDEEEEVQDQRDPAESSADQTEQPTAIENNLHNEGMVEQSQNDSDDVFEAADKVSPLAPPPAP 2173
                        |.|......||..|   :.:..::..|..::.....:..|.::.:|  .|...
  Rat  1594 ------------RPPTREDPPQTFYP---QKSFPDKASVNGAEQTQKTITPAYNRFTP--KPYTS 1641

  Fly  2174 VQPPTPRSGRAPFHISNILK---------RTAPPPS------------SPIGDSCTSIETQYTSQ 2217
            ...|..|...:|....|:|.         .:.||||            .|..||  .:|| ::..
  Rat  1642 SARPFERKFESPKFNHNLLPSETVHKPELSSKPPPSPKTLMKAHSSTQPPEFDS--GVET-FSVH 1703

  Fly  2218 ASLPVGPPNATSTPFSSSMSLPIAGPVNNQPSA-------NGRFPTLPREPSTSRGFFDSNGGTL 2275
            ...|....|..||       :|.|.||:  |||       :|....     :|:||.|:||||.|
  Rat  1704 TDKPKYQINNIST-------MPKAVPVS--PSAVEEDEDEDGHTVV-----ATARGIFNSNGGVL 1754

  Fly  2276 ADKLWHVSLQIPPGAIPAGVRQEIYFTVSDPRMGQAVGGPPLDMENGETMLSPLVMCGPQGLEFL 2340
            :.....||:.||.||||.|:.|||||.|.  |....:  ||||.|.|||:|||||||||.||:||
  Rat  1755 SSIETGVSIIIPQGAIPEGIEQEIYFKVC--RDNSIL--PPLDKEKGETLLSPLVMCGPHGLKFL 1815

  Fly  2341 VPVTLNIPHCAGRTA-SLGLALKATDSEKNLHTEWDNIDLPSN----AAAHTVSVKVDHF 2395
            .||.|.:||||..|. ....|||::||.......|.|..||.:    ..|:.|||.:|||
  Rat  1816 KPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF 1875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	54/84 (64%)
		PDZ_signaling	396..477	CDD:238492	33/80 (41%)
		PDZ_signaling	633..710	CDD:238492	37/78 (47%)
		SH3_ZO	729..790	CDD:212793	29/60 (48%)
		GuKc	831..1007	CDD:214504	81/177 (46%)
		ZU5	2263..2351	CDD:279170	51/87 (59%)
Tjp1	XP_038961189.1	PDZ_signaling	115..200	CDD:238492	54/84 (64%)
		PDZ	276..356	CDD:214570	34/83 (41%)
		PDZ	518..594	CDD:395476	37/75 (49%)
		SH3_ZO-1	610..674	CDD:212959	32/63 (51%)
		GuKc	708..887	CDD:214504	82/179 (46%)
		PHA03247	<1265..1691	CDD:223021	106/635 (17%)
		ZU5	1742..1841	CDD:395639	57/102 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348852
Domainoid	1	1.000	113	1.000	Domainoid score	I5991
eggNOG	1	0.900	-	-		E1_KOG3580
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	635	1.000	Inparanoid score	I799
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175136at2759
OrthoFinder	1	1.000	-	-		FOG0001438
OrthoInspector	1	1.000	-	-		otm44449
orthoMCL	1	0.900	-	-		OOG6_103390
Panther	1	1.100	-	-	O	PTHR13865
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1692
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.850