Protein Alignment pyd and Tjp3

DIOPT Version :10

• Sequence 1: NP_001246998.1
• Gene: pyd / 41062
• FlyBaseID: FBgn0262614
• Length: 2395
• Species: Drosophila melanogaster
• Sequence 2: NP_001269025.1
• Gene: Tjp3 / 27375
• MGIID: 1351650
• Length: 913
• Species: Mus musculus
• Alignment Length: 963
• Identity: 316/963 - (32%)
• Similarity: 474/963 - (49%)
• Gaps: 164/963 - (17%)

  Fly   237 RFKKGDR---TTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQV 298
            ||:..|.   |.||.||..:.:.|..|||||||||.|.   |:|  |:.||||:.|||||.||:.
Mouse     4 RFQVADMEELTIWEQHTATLYKDPRRGFGIAVSGGHDR---ASG--SVVVSDVVPGGPAEGRLRT 63

  Fly   299 NDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVK--RRVPLNPINAAGAVQHQHS------HS 355
            .|.|:.|||||:|||..|.|:|:|:....|..:.||  |||.|....|:.|..||.|      |.
Mouse    64 GDHIVMVNGVSVENVTSAFAIQILKTCTKTANVTVKRPRRVQLPATKASPASGHQLSDQEEADHG 128

  Fly   356 LSSVGLMANGS----------------------------GGVAPTPITSLSQPNSLN-----SSL 387
            ....|..::||                            ||         |:.|.|:     ..|
Mouse   129 RGYEGDSSSGSGRSWGERSRRSRAGRRGRVGSHGRRSSGGG---------SEANGLDLVSGYKRL 184

  Fly   388 VQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNC 452
            .:.....:|:|..|.|....:::||.||.::|:|.|:...   |.|..:.|||||:|.:|:..:.
Mouse   185 PKQDVLMRPLKSVLVKRRNSEEFGVKLGSQIFIKHITESG---LAARNHGLQEGDLILQINGVSS 246

  Fly   453 GDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSS 517
            .: :||.:.:::|:..:..|.|:||||                    ||.......|.||  .|.
Mouse   247 AN-LSLSDTRRLIEKSEGELTLLVLRD--------------------SGQFLVNIPPAVS--DSD 288

  Fly   518 NNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNL---TPRGRSRGPIMDGVSL 579
            ::.:||      .|..:..|...||:.....|........|.:::.   ||:.|.|
Mouse   289 SSLMED------ISDLTSELSQAPPSHVPPPPLKGQRSPEDSQTDSPVETPQPRRR--------- 338

  Fly   580 QQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFY--SSRRQLYEERQSAEPRFISFQKEG 642
               :|.|     .|.||.||..|        |.::.|.|  .||:.|.:...|.:.|.:||.|..
Mouse   339 ---ERSV-----NSRAIAEPESP--------GESRYDIYRVPSRQSLEDRGYSPDTRVVSFPKGA 387

  Fly   643 SVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQ--DRI 705
            |:|:||.|||:.||||:.||.||||..||:..||:||:||.|....:||||||.|||.|.  :.:
Mouse   388 SIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDEILQVNGMPFRNLTREEAVQFLLGLPPGEDM 452

  Fly   706 DLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCD-NPSKGEMAFKAGDVFRVIDTL---------HN 760
            :|:.|..::.:.::|.::.||||:|:|||..: :|..| :.|..||||.|:|||         |:
Mouse   453 ELVTQSKQDIFKKMVQSRVGDSFYIRTHFELEPSPPYG-LGFTRGDVFHVVDTLYPGSGPGHGHS 516

  Fly   761 GVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMN-------ANESRGNFFR--- 815
            ...|.|...::||..:|.:||||||:||||:||:.:  |.::...       .:..|..|:|
Mouse   517 SHGGLWLAARMGRDLREQERGVIPNQSRAEQLASLE--AAQRAAGVGPGASVGSNPRAEFWRLRG 579

  Fly   816 RRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFP 880
            .||.|.:.|...|||   |:........:|.|||||||...|.||||:.|||:|:|.::|..:.|
Mouse   580 LRRGTKKASTQRSRE---DLSALTRQGHYPPYERVVLREASFKRPVVILGPVADIAMKKLTTEMP 641

  Fly   881 DKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTD 945
            ::|...    :..:.|....:|::|..:|.:.:|.||||||:||:|::||||.|:||:|||...:
Mouse   642 EEFEIA----ESMSRTDSPSKIIKLDTVRVIAERDKHALLDVTPSAIERLNYVQYYPIVIFCAPE 702

  Fly   946 SKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIAL-SDEESWYRKLRDSIDLQQSG 1009
            |:..:|.||..|..|:.:||::|..|.|||::...|:|:..|.| ...:|||::::..|..||:.
Mouse   703 SRPALKALREWLAPASRRSSRRLYAQAQKLQKHSGHLFTATIPLHGTSDSWYQEVKAVIQQQQAR 767

  Fly  1010 AVWMSESKPVESLSDDFLFP-----MTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSD 1069
            .:|.:|.: :.|.|:|...|     .::..||..|...||.|.:.|..|.......||.|.....
Mouse   768 PIWTAEDQ-LNSSSEDLDLPGHGLAASSGDLSCDSRTNSDYEDTDGEGAYTDREGGPQDVDEEVA 831

  Fly  1070 PSIATNQDN---LDRDRDIIGEG--LPPPYTVPYDHAVPANPNRRQTMDSSKY 1117
            |:.......   :|..:.::|.|  :...:....|.....:..|:.:|.:.|:
Mouse   832 PTALARSSEPVWVDDHQGLMGHGTTITDKWETQADSHYTQDQRRQDSMRTYKH 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ1_ZO1-like	249..335	CDD:467209	44/87 (51%)
		PDZ2_ZO1-like_ds	397..479	CDD:467210	26/81 (32%)
		PDZ3_ZO1-like_domain	632..711	CDD:467211	41/80 (51%)
		SH3_ZO	729..790	CDD:212793	29/70 (41%)
		GuKc	831..1007	CDD:214504	67/176 (38%)
		ZU5	2264..2365	CDD:459941
Tjp3	NP_001269025.1	PDZ_canonical	19..100	CDD:483948	43/85 (51%)
		PDZ2_ZO1-like_ds	194..272	CDD:467210	26/81 (32%)
		PDZ3_ZO1-like_domain	377..458	CDD:467211	41/80 (51%)
		SH3	473..546	CDD:473055	32/73 (44%)
		GuKc	589..765	CDD:214504	70/182 (38%)