DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and Tjp3

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_001269025.1	Gene:	Tjp3 / 27375	MGIID:	1351650	Length:	913	Species:	Mus musculus

Alignment Length:	963	Identity:	316/963 - (32%)
Similarity:	474/963 - (49%)	Gaps:	164/963 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 RFKKGDR---TTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQV 298
            ||:..|.   |.||.||..:.:.|..|||||||||.|.   |:|  |:.||||:.|||||.||:.
Mouse     4 RFQVADMEELTIWEQHTATLYKDPRRGFGIAVSGGHDR---ASG--SVVVSDVVPGGPAEGRLRT 63

  Fly   299 NDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVK--RRVPLNPINAAGAVQHQHS------HS 355
            .|.|:.|||||:|||..|.|:|:|:....|..:.||  |||.|....|:.|..||.|      |.
Mouse    64 GDHIVMVNGVSVENVTSAFAIQILKTCTKTANVTVKRPRRVQLPATKASPASGHQLSDQEEADHG 128

  Fly   356 LSSVGLMANGS----------------------------GGVAPTPITSLSQPNSLN-----SSL 387
            ....|..::||                            ||         |:.|.|:     ..|
Mouse   129 RGYEGDSSSGSGRSWGERSRRSRAGRRGRVGSHGRRSSGGG---------SEANGLDLVSGYKRL 184

  Fly   388 VQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNC 452
            .:.....:|:|..|.|....:::||.||.::|:|.|:...   |.|..:.|||||:|.:|:..:.
Mouse   185 PKQDVLMRPLKSVLVKRRNSEEFGVKLGSQIFIKHITESG---LAARNHGLQEGDLILQINGVSS 246

  Fly   453 GDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSS 517
            .: :||.:.:::|:..:..|.|:||||                    ||.......|.||  .|.
Mouse   247 AN-LSLSDTRRLIEKSEGELTLLVLRD--------------------SGQFLVNIPPAVS--DSD 288

  Fly   518 NNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNL---TPRGRSRGPIMDGVSL 579
            ::.:||      .|..:..|...||:.....|........|.:::.   ||:.|.|
Mouse   289 SSLMED------ISDLTSELSQAPPSHVPPPPLKGQRSPEDSQTDSPVETPQPRRR--------- 338

  Fly   580 QQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFY--SSRRQLYEERQSAEPRFISFQKEG 642
               :|.|     .|.||.||..|        |.::.|.|  .||:.|.:...|.:.|.:||.|..
Mouse   339 ---ERSV-----NSRAIAEPESP--------GESRYDIYRVPSRQSLEDRGYSPDTRVVSFPKGA 387

  Fly   643 SVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQ--DRI 705
            |:|:||.|||:.||||:.||.||||..||:..||:||:||.|....:||||||.|||.|.  :.:
Mouse   388 SIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDEILQVNGMPFRNLTREEAVQFLLGLPPGEDM 452

  Fly   706 DLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCD-NPSKGEMAFKAGDVFRVIDTL---------HN 760
            :|:.|..::.:.::|.::.||||:|:|||..: :|..| :.|..||||.|:|||         |:
Mouse   453 ELVTQSKQDIFKKMVQSRVGDSFYIRTHFELEPSPPYG-LGFTRGDVFHVVDTLYPGSGPGHGHS 516

  Fly   761 GVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMN-------ANESRGNFFR--- 815
            ...|.|...::||..:|.:||||||:||||:||:.:  |.::...       .:..|..|:|
Mouse   517 SHGGLWLAARMGRDLREQERGVIPNQSRAEQLASLE--AAQRAAGVGPGASVGSNPRAEFWRLRG 579

  Fly   816 RRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFP 880
            .||.|.:.|...|||   |:........:|.|||||||...|.||||:.|||:|:|.::|..:.|
Mouse   580 LRRGTKKASTQRSRE---DLSALTRQGHYPPYERVVLREASFKRPVVILGPVADIAMKKLTTEMP 641

  Fly   881 DKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTD 945
            ::|...    :..:.|....:|::|..:|.:.:|.||||||:||:|::||||.|:||:|||...:
Mouse   642 EEFEIA----ESMSRTDSPSKIIKLDTVRVIAERDKHALLDVTPSAIERLNYVQYYPIVIFCAPE 702

  Fly   946 SKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIAL-SDEESWYRKLRDSIDLQQSG 1009
            |:..:|.||..|..|:.:||::|..|.|||::...|:|:..|.| ...:|||::::..|..||:.
Mouse   703 SRPALKALREWLAPASRRSSRRLYAQAQKLQKHSGHLFTATIPLHGTSDSWYQEVKAVIQQQQAR 767

  Fly  1010 AVWMSESKPVESLSDDFLFP-----MTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSD 1069
            .:|.:|.: :.|.|:|...|     .::..||..|...||.|.:.|..|.......||.|.....
Mouse   768 PIWTAEDQ-LNSSSEDLDLPGHGLAASSGDLSCDSRTNSDYEDTDGEGAYTDREGGPQDVDEEVA 831

  Fly  1070 PSIATNQDN---LDRDRDIIGEG--LPPPYTVPYDHAVPANPNRRQTMDSSKY 1117
            |:.......   :|..:.::|.|  :...:....|.....:..|:.:|.:.|:
Mouse   832 PTALARSSEPVWVDDHQGLMGHGTTITDKWETQADSHYTQDQRRQDSMRTYKH 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	42/84 (50%)
		PDZ_signaling	396..477	CDD:238492	25/80 (31%)
		PDZ_signaling	633..710	CDD:238492	41/78 (53%)
		SH3_ZO	729..790	CDD:212793	29/70 (41%)
		GuKc	831..1007	CDD:214504	67/176 (38%)
		ZU5	2263..2351	CDD:279170
Tjp3	NP_001269025.1	PDZ_signaling	19..99	CDD:238492	42/84 (50%)
		PDZ_signaling	194..270	CDD:238492	24/79 (30%)
		PDZ_signaling	378..443	CDD:238492	36/64 (56%)
		SH3	473..546	CDD:302595	32/73 (44%)
		GuKc	589..765	CDD:214504	70/182 (38%)
		Guanylate_kin	620..764	CDD:279019	57/147 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845444
Domainoid	1	1.000	98	1.000	Domainoid score	I7157
eggNOG	1	0.900	-	-		E1_KOG3580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6759
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175136at2759
OrthoFinder	1	1.000	-	-		FOG0001438
OrthoInspector	1	1.000	-	-		otm42386
orthoMCL	1	0.900	-	-		OOG6_103390
Panther	1	1.100	-	-	LDO	PTHR13865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3326
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.730