DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and Frmpd2

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_036014873.1	Gene:	Frmpd2 / 268729	MGIID:	2685472	Length:	1383	Species:	Mus musculus

Alignment Length:	1010	Identity:	191/1010 - (18%)
Similarity:	333/1010 - (32%)	Gaps:	366/1010 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LASEQQQQQQQQQQQH--QQVQEQQQLGRRKAAAAAEINLANQVYWLGKQKTRSRS-----RSNS 169
            |.|.|.....|...:|  .:...|.:..:..:.::|....||.:.|:.|.......     ..::
Mouse   618 LCSSQHWFNAQTGSKHPSHRFTGQDKFAQIASLSSAHQTQANPITWIQKLSCSENELCVPRLQDA 682

  Fly   170 VGNRSITSCMGGGGGGGEKERERGGDRDRPYIRNVDDLLQALGKRD---------GGDN---NSN 222
            .|.:..|| |....|..|..:||.|  ..||...  :.|.::|...         .|.:   .||
Mouse   683 TGGQLGTS-MENKQGFKEPGKERIG--SSPYTGG--EQLHSIGLNQKPAQTVFGTAGHSMCAGSN 742

  Fly   223 LL---------ETASTHSSSQRRRFKKG--DRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFAN 276
            .|         ::.|...:|:|    ||  .....:...|.:.|.|.:|||..::.|.|.....:
Mouse   743 CLGRRTQICCFDSVSGSQNSKR----KGLFGEPNQDIVCVMLKRDPVHGFGFVINEGEDAEQTRS 803

  Fly   277 GDPSIAVSDVLKGGPAE--DRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVPL 339
            |   |.:|.::.|||||  .:::...:|:::|.:|||...::.||:::::|.:.::|::.:
Mouse   804 G---IFISSLIPGGPAERAKKIKPGGKILALNHISLEGFTFSMAVRMIQNSPDDMELIISQ---- 861

  Fly   340 NPINAAGAVQHQHSHSLSSVGL-----------------------------MANGSGGVAPTPIT 375
             |....|.:..:..:|.:|.|:                             ||.|:|...|:|:.
Mouse   862 -PKGVCGTIHSEEKNSTASSGMFCTDILSNRCQGRQSPHIHDQDRSVRGTEMAQGAGSCPPSPLQ 925

  Fly   376 S----------LSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEI---SSKA 427
            :          :.:..:|..|:....::..|      .||            ::||.|   ...|
Mouse   926 TNTGEIYFVELVKEDGTLGFSVTGGINTSVP------HGG------------IYVKSIIPGGPAA 972

  Fly   428 REQLNANGYSLQEGDIITRIHNTN-CGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNL 491
            :|     |..|| ||.:.::...: ||  ::.|:|.:.:.|..:               |::|.|
Mouse   973 KE-----GQILQ-GDRLLQVDGVSLCG--LTHKQAVQCLKGPGQ---------------VARLVL 1014

  Fly   492 NNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGL 556
            .......|         ||   |.|:::.:.|.::       :.:|....|.|.::..::.
Mouse  1015 ERRGPRAA---------PQ---CPSADDRMGDVHM-------AVSLVTARPGRPASSVSVT---- 1056

  Fly   557 NDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGA--AQEDFYS 619
            :..|..:..:..|||.   |.|..|::|                         |..  .:.|...
Mouse  1057 DGPKFEVKLKKNSRGL---GFSFVQMER-------------------------GNCIHTKSDLVR 1093

  Fly   620 SRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQG-LMPGDKILKVND 683
            .:|                                 :|     ||.||...| :..||.||.||.
Mouse  1094 IKR---------------------------------LF-----PGQPAEEHGAIAAGDIILAVNG 1120

  Fly   684 MDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKA 748
            ..:.|:..:|.:..|....:.:.|::  |:                         |..|
Mouse  1121 KPIEGLAFQEVLHLLRGAPEEVTLLL--CR-------------------------PPPG------ 1152

  Fly   749 GDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNF 813
                 ::..:..|    ||.               |..|..:.|..|....::
Mouse  1153 -----ILPEMEPG----WQT---------------PELSGDQRLTMATCAGSE------------ 1181

  Fly   814 FRRRRSTHRRSKSLSRE-NWDDVVFSDS---ISKFP--AYERVVLRHPGFVRPVVLFGPVSDLAR 872
                     :|.||.:| ||.|....|:   :|..|  :|:.        ||.|     ..|..:
Mouse  1182 ---------QSPSLDQEDNWRDSTSLDAGEGLSPGPESSYKD--------VRQV-----KGDREK 1224

  Fly   873 ER---------------LAKDFPD----KFSTPLQDDDKSAATSGKCRIVRLSNI---RDVMDRG 915
            ||               :.|..|:    ..:|.|:.|.:....| .|.|.||.::   ||..|..
Mouse  1225 ERPWAKSWMHPMESHPHVCKLHPEPETPALATSLEKDMRQNCYS-VCDIRRLGSLELDRDGADGA 1288

  Fly   916 KHALLDITPNAVDRLNY-------AQFYPVVIFLKTDSKHVIKQLRHGLPK-----AAHKSSKKL 968
            ...|.:.:...||...|       |...|....|:.||:.:      .||:     |..|||  |
Mouse  1289 TCFLPESSSLTVDYEEYLTLTSASAGQLPCEECLEADSETI------PLPQFCSLGALLKSS--L 1345

  Fly   969 LEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSI 1003
            .|:.|..|..|..: ...:...:...|.|..|..:
Mouse  1346 PEESQGSESDWEDL-DEPVDRDEVLRWTRSARQPL 1379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	25/86 (29%)
		PDZ_signaling	396..477	CDD:238492	18/84 (21%)
		PDZ_signaling	633..710	CDD:238492	16/77 (21%)
		SH3_ZO	729..790	CDD:212793	7/60 (12%)
		GuKc	831..1007	CDD:214504	49/212 (23%)
		ZU5	2263..2351	CDD:279170
Frmpd2	XP_036014873.1	PKc_like	6..188	CDD:419665
		Ubiquitin_like_fold	329..422	CDD:421700
		B41	334..538	CDD:214604
		PH-like	534..635	CDD:418428	5/16 (31%)
		PDZ_signaling	775..859	CDD:238492	25/86 (29%)
		PDZ	930..1018	CDD:214570	23/128 (18%)
		PDZ	1061..1150	CDD:214570	27/181 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910