DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and pals1a

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_919344.1	Gene:	pals1a / 252845	ZFINID:	ZDB-GENE-020712-1	Length:	703	Species:	Danio rerio

Alignment Length:	763	Identity:	143/763 - (18%)
Similarity:	281/763 - (36%)	Gaps:	166/763 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 VQHQHSH--------SLSSVGLM------ANGSGGVAPTPIT----------SLSQPNSLNSSLV 388
            :.|.|.|        ::.:...|      ::|.||   |.|.          ::..|:.|.:..:
Zfish    10 IPHTHLHHTPPHMRAAMMTTSHMNGYVTESDGGGG---TDIVEEGVQRHREMAVDCPSELGARTL 71

  Fly   389 QNASSGQPIKVTLTKGG--KKDDYG-----VVLGCRLFVKEISSKAREQLNANGYSLQEGDIITR 446
            ....|.|..|:...:..  ::::.|     :.|...:.:|::|...:..::...:...||.
Zfish    72 PVRRSAQLEKIRQQQEDRRRREEEGRSRQELDLNSSMRLKKLSQNPKVGIDNPTFEQMEGP---- 132

  Fly   447 IHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQ-ASGNIYATHQPQ 510
              ..:.|...||.....:::          |.|:.......|.:||:|.|.: ....:....:|.
Zfish   133 --GGSAGGLQSLIAPPALLE----------LEDLLMSLKQVQHSLNDSQSQEDVELVLQLVQKPD 185

  Fly   511 VSGCSSSNNN----LEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRG 571
            .....|.:|:    :..|..|...:..:|.|..:......|..:..|.    |.|:|......:.
Zfish   186 FQKAFSIHNSVAHYMNRPSPPYPLTDHAQTLAQEVEVMVQNSSHKEGL----ELSSLLSTSHMQA 246

  Fly   572 PIM--DGVSLQQLD-RPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEP 633
            .:|  |.|:.|::. .|:.|:...|..:.:          .||..                   .
Zfish   247 LMMAHDSVAEQEMQLEPLVPSVNASETLTQ----------WGGET-------------------V 282

  Fly   634 RFISFQKEGSVGIRLTGGNEA-GIFVTAVQPGSPASLQGLM-PGDKILKVNDMDMNGVTREEAVL 696
            :.:..:|...:.:..|..|:. .:.::.:..|..|...||: .||:||::|.:::.|....|...
Zfish   283 KIVRIEKAKDIPLGATVRNDMDSVVISRIVKGGAAERSGLLHEGDEILEINGVEIRGKDVNEVFD 347

  Fly   697 FLLSLQDRIDLIV----QYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGE--------MAFKAG 749
            .|..:...:..::    |.......|.|.       |:|.||..| ||...        :.|:.|
Zfish   348 ILADMHGVLSFVLIPSAQIKSPPIKETVV-------HVKAHFDYD-PSDDPYVPCRELGLCFQKG 404

  Fly   750 DVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFF 814
            |:..:|.   ......||..:.|....:...|::|.||..::  ......|.:|....|..|..:
Zfish   405 DILHIIS---QDDPNWWQAYRDGDEDNQPLAGLVPGKSFQQQ--REAMKQTIEEDKEPEKTGKLW 464

  Fly   815 RRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRH--PGFVRPVVLFGPVS---DLARER 874
            ..:::..:|.|.....|.:|...::.|.   .||.:.|.|  ....||:.|.||.:   :..|:|
Zfish   465 CAKKTKKKRKKMQYNANKNDDFDNEEIL---TYEEMALYHQPANRKRPIALIGPPNCGQNELRQR 526

  Fly   875 LAKDFPDKFSTPLQDDDKS---AATSGK----------------CRIVR------------LSNI 908
            |....||:|:.|:....:|   |..:|:                .:.:.            ..::
Zfish   527 LLSTEPDRFAGPVPHTTRSRRDAEANGRDYHFVSRQAFEMDSAAGKFIESGEFEKNFYGTSTDSV 591

  Fly   909 RDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSK-----KL 968
            |.|::.||..||.:...::..|..:...|.:||:...|:   ::||..|.| .:|:.|     .:
Zfish   592 RQVINTGKICLLCVHTQSLKVLRSSDLKPYIIFIAPPSQ---ERLRALLAK-DNKNPKPEELRDI 652

  Fly   969 LEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSES 1016
            :|:.:::|:.:.|:|...|..:|.:..|::|...|:...:...|:..|
Zfish   653 IEKAREMEQNYGHLFDAAIVNTDLDKSYQELLRLINKLDTEPQWVPSS 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492	10/87 (11%)
		PDZ_signaling	633..710	CDD:238492	15/82 (18%)
		SH3_ZO	729..790	CDD:212793	18/68 (26%)
		GuKc	831..1007	CDD:214504	48/216 (22%)
		ZU5	2263..2351	CDD:279170
pals1a	NP_919344.1	L27_N	150..197	CDD:286189	10/56 (18%)
		PDZ_signaling	282..361	CDD:238492	15/78 (19%)
		SH3_MPP5	377..439	CDD:212969	16/65 (25%)
		Guanylate_kin	506..690	CDD:279019	41/187 (22%)
		GuKc	519..689	CDD:214504	36/173 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910