DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyd and GRIP1

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:XP_016874587.1 Gene:GRIP1 / 23426 HGNCID:18708 Length:1188 Species:Homo sapiens


Alignment Length:1359 Identity:269/1359 - (19%)
Similarity:445/1359 - (32%) Gaps:402/1359 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKPSTRRRSFKTKPPKSNVYNPLVRYRPTAYVRNGIIGGAEGPGSSGVYQIADRVYTTSKMFLRD 65
            |..|.::..|.|..          .|.|...:.|.|....:|.     .|..:::|.::...| |
Human    11 MAESVKKHQFSTSE----------SYLPATLILNSISFNTDGS-----IQYKEKLYFSASEAL-D 59

  Fly    66 GYMYPRQPGQTMDPRFPLELHEFPQQFGATGLQLVSAPKVHIAGEYLASEQQQQQQQQQQQHQQV 130
            .|:            ....|:..|.... |.:.|..:|.     |:||.....:....:...|..
Human    60 AYI------------DDFHLNYEPPDID-TKVNLDQSPL-----EFLAKSNSDESPYTKSASQTK 106

  Fly   131 QEQQQLGRRKAAAAAEINLANQVYWLGKQKTRSRSRSNSVGNRSITSCMGGGGGGGEKER----E 191
            .....|..|:.:...|...:..|..:.|:.|            ::...:.||.....|.|    .
Human   107 PPDGALAVRRQSIPEEFKGSTVVELMKKEGT------------TLGLTVSGGIDKDGKPRVSNLR 159

  Fly   192 RGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETASTHSSSQRRRFKKGDRTTWE--------- 247
            :||...|....:|.|.::|:       |..||.:.......|..:..  |:|...|         
Human   160 QGGIAARSDQLDVGDYIKAV-------NGINLAKFRHDEIISLLKNV--GERVVLEVEYELPPVS 215

  Fly   248 -------YHTVAVT-RVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPA--EDRLQVNDRI 302
                   :.||.|| ...|..||..:.||..:..  |....:.::.|..||||  |..::..||:
Human   216 VQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDR--NKSRPVVITCVRPGGPADREGTIKPGDRL 278

  Fly   303 ISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSG 367
            :||:|:.|....:|.|:.:|:..|....|:::                   :.:|.:..:|..||
Human   279 LSVDGIRLLGTTHAEAMSILKQCGQEAALLIE-------------------YDVSVMDSVATASG 324

  Fly   368 ----GVAPTPITSLSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAR 428
                .||.||..||..  :|.:|:..|.   |.|.:...|                    |:...
Human   325 PLLVEVAKTPGASLGV--ALTTSMCCNK---QVIVIDKIK--------------------SASIA 364

  Fly   429 EQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVS------ 487
            ::..|    |..||.|..|..|:. :..:|.||.:.:....:::.|.:|.....:.|:.      
Human   365 DRCGA----LHVGDHILSIDGTSM-EYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHVK 424

  Fly   488 ------QLNLNNSASHQAS---GNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPT 543
                  ||..::.||:.:|   .:.|.|:.|......:    |..|..|...|         ||.
Human   425 IQRSDRQLTWDSWASNHSSLHTNHHYNTYHPDHCRVPA----LTFPKAPPPNS---------PPA 476

  Fly   544 RTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGS 608
            ..|              |:.:|..      |...||..|:....|....|.:         |||:
Human   477 LVS--------------SSFSPTS------MSAYSLSSLNMGTLPRSLYSTS---------PRGT 512

  Fly   609 --SGGAAQEDFYSS---------------RRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEAGI 656
              .....::||.||               ..:..|...:|:|       ....||:|.|    .:
Human   513 MMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADP-------VTGFGIQLQG----SV 566

  Fly   657 FVTA----------VQPGSPASLQGLMP-GDKILKVNDMDMNGVTREEAVLFL--LSLQDRIDLI 708
            |.|.          ::..|||...|::. ||:::.:|.:.....|.|||...|  .|:..::.|.
Human   567 FATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLE 631

  Fly   709 VQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAF----------KAGDVFRVIDTLHNGVV 763
            :::   :..|.|....| :||:|.      |.|..:..          |.||...:.|.....|.
Human   632 IEF---DVAESVIPSSG-TFHVKL------PKKHNVELGITISSPSSRKPGDPLVISDIKKGSVA 686

  Fly   764 GSWQVLKIGRGHQEMQRGVIPNKS---------RAEELATAQFNATKKEMNANESRGNF-----F 814
            .....|::|.....:....:.|.|         :.|:|...:....:...:..||.|..     .
Human   687 HRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVEL 751

  Fly   815 RRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPG----FVRPVVLFG-PVSD----- 869
            :|.......:.|.:.|.:|.::.| |::|....||....|.|    .:....|.| |:|:     
Human   752 KRYGGPLGITISGTEEPFDPIIIS-SLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLL 815

  Fly   870 -LARERLAKDFPDKFSTPLQDDDKSAATSGKCRI-VRLSNIRDVMDRGKHA-----LLDITPNAV 927
             :|.|.:.      .....|.|.:||::..|..| ..||::.||.:....|     |.|:.|:.|
Human   816 QMAGETVT------LKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTV 874

  Fly   928 DRLNYA-------------------------------------------------QFYPVVIFLK 943
            ..::.|                                                 |.||.|....
Human   875 PSVDSAVDSWDGSAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSY 939

  Fly   944 TDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESW-----YRKLRDSI 1003
            .|..   :....|...||..:      :.::.|..||.      ||.|.|:.     .|:|..:|
Human   940 EDWD---RSTASGFAGAADSA------ETEQEENFWSQ------ALEDLETCGQSGILRELEATI 989

  Fly  1004 DLQQSGAVWMSESK---PVESLSDDFLF-PMTTSRLSYASSPESDLELSPGPSASLSLGNLPQLV 1064
               .||:......:   |...|.....| ..::||..|:.:..|:...|.....|::|..:.|.:
Human   990 ---MSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEI 1051

  Fly  1065 KASSDPS-IATNQDNLDRDRDI------IGEGL------------PPPYTV----PYDHAVPANP 1106
            |....|: :..::..|.:|.|:      :.:||            ..|..:    |||..:..|.
Human  1052 KEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNH 1116

  Fly  1107 NRRQTMDSSKYSIYGTNVPPQQQQPGVGGDTAAVRPQSLYGINAPDLPPRIDRQSKPGD 1165
            .|.:..|...       |.|...:.|...|....|       |.......||:||.|||
Human  1117 VRTRDFDCCL-------VVPLIAESGNKLDLVISR-------NPLASQKSIDQQSLPGD 1161

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 27/87 (31%)
PDZ_signaling 396..477 CDD:238492 14/80 (18%)
PDZ_signaling 633..710 CDD:238492 21/89 (24%)
SH3_ZO 729..790 CDD:212793 13/79 (16%)
GuKc 831..1007 CDD:214504 48/246 (20%)
ZU5 2263..2351 CDD:279170
GRIP1XP_016874587.1 PDZ_signaling 128..208 CDD:238492 20/100 (20%)
PDZ_signaling 227..310 CDD:238492 25/84 (30%)
PDZ_signaling 325..408 CDD:238492 24/112 (21%)
PDZ_signaling 545..633 CDD:238492 23/98 (23%)
PDZ_signaling 646..730 CDD:238492 16/89 (18%)
PDZ_signaling 746..827 CDD:238492 17/87 (20%)
PDZ_signaling 1062..1142 CDD:238492 16/86 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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