DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and Tjp1

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_006540841.1	Gene:	Tjp1 / 21872	MGIID:	98759	Length:	1875	Species:	Mus musculus

Alignment Length:	2332	Identity:	626/2332 - (26%)
Similarity:	938/2332 - (40%)	Gaps:	602/2332 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 RERGGDRDRPYIRNVDDLLQALG------------KR-----DGGDNNSNLLETASTHSSSQRR- 236
            |||.||:.: |.:.:..|..|:|            ||     ...:|......|.|....|.||
Mouse    20 RERSGDKMK-YQKYLTVLQMAIGVTPSNRGSLLPLKRKLWVTPSSENPHGATSTVSQGKPSLRRI 83

  Fly   237 -----RFKKGD--------------RTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIA 282
                 |.|..|              ...||.|||.:.|.||:|||||:|||||||||.:|:.||.
Mouse    84 KGRLHRSKSLDSIDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIV 148

  Fly   283 VSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRR----VPLN--- 340
            :||||||||||.:||.|||:..|||||::|||:|.|||.||.||...::.::|:    :|::
Mouse   149 ISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPD 213

  Fly   341 --PI--NAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSL----NSSLVQNASSGQPI 397
              |:  |...:...:.....:..|.:||.....:.....|.|:..||    :...|.::...:|.
Mouse   214 PEPVSDNEDDSYDEEVHDPRAGRGALANRRSEKSWARDRSASRERSLSPRSDRRSVASSQPAKPT 278

  Fly   398 KVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAK 462
            ||||.|..|.::||:.|...:||||||   ::.|.|...::||||::.:|:.| ..:.|||.:||
Mouse   279 KVTLVKSRKNEEYGLRLASHIFVKEIS---QDSLAARDGNIQEGDVVLKINGT-VTENMSLTDAK 339

  Fly   463 KIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSS-----SNNNLE 522
            .:|:..|.:|.:||.|| ...|.::..:|::|. |.|:    |:.:..:|...|     |..:.:
Mouse   340 TLIERSKGKLKMVVQRD-ERATLLNVPDLSDSI-HSAN----ASERDDISEIQSLASDHSGRSHD 398

  Fly   523 DPYLPGGASYSSQNLYVQPPTRTSNGPN--INGNGLNDEKSNLTPRGRSRGPI----------MD 575
            .|  |..:...|.:...:|...::..|.  .||:..:.|:..::..|....|:          ::
Mouse   399 RP--PRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAISTPVKHVDDHPPKAVE 461

  Fly   576 GVSLQQLDRPVTPTRGRSAAIDEPPRPPP------------PRGSSGGA----AQEDFYSSRRQL 624
            .|::::.::. |||.         |.|.|            |...|.||    |.||...
Mouse   462 EVTVEKNEKQ-TPTL---------PEPKPVYAQVGQPDVDLPVSPSDGALPNSAHEDGIL----- 511

  Fly   625 YEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGV 689
               |.|.  :.:.|:|..|||:||.|||:.||||..|...|||:.:||..||:||:||::|...:
Mouse   512 ---RPSM--KLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNI 571

  Fly   690 TREEAVLFLLSLQ--DRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVF 752
            .|||||||||.|.  :.:.::.|..|:.|..:|.:..||||:|:|||..:..|...::|..|:||
Mouse   572 IREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVF 636

  Fly   753 RVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRR 817
            ||:|||:||.:|||..::||:.|:|::||:||||:|||:||:.|:...|   .|...|.:|:|.|
Mouse   637 RVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPK---TAGGDRADFWRFR 698

  Fly   818 RSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDK 882
            ..  |.||...|::.:|:......:|||||||||||..||:|||.:|||::|:|||:||::.||.
Mouse   699 GL--RSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDI 761

  Fly   883 FSTPLQDDDKSAATSGKCR-IVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDS 946
            :.. .:.:.:.|.|..:.. |:||..|:.::|:.||||||:||||||||||||:||:|:||..||
Mouse   762 YQI-AKSEPRDAGTDHRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDS 825

  Fly   947 KHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIAL-SDEESWYRKLRDSIDLQQSGA 1010
            |..:|.:|..|...:.||::||.|:..||.:...|:|:|.|.| |..:.||..|:::|..||:..
Mouse   826 KQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQL 890

  Fly  1011 VWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSDPSIATN 1075
            ||:||.|...:.|||  ..:...||||.|:|.|:..:....|...|     ......::....|:
Mouse   891 VWVSEGKADGATSDD--LDLHDDRLSYLSAPGSEYSMYSTDSRHTS-----DYEDTDTEGGAYTD 948

  Fly  1076 QDNLDRDRDIIGEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGVGGDTAAV 1140
            |:..:...|.:  |.||...:...    :.|.|.   |||.........||...|         .
Mouse   949 QELDETLNDEV--GTPPESAITRS----SEPVRE---DSSGMHHENQTYPPYSPQ---------A 995

  Fly  1141 RPQSLYGINAPDLPPRIDRQSK-----PGDIPLNTSGSSSRNGTLGRSAQERLFGKAVVQDDVQA 1200
            :||:::.|::|.|.|...::::     |...|..|..||                         |
Mouse   996 QPQAIHRIDSPGLKPASQQKAEASSPVPYLSPETTPASS-------------------------A 1035

  Fly  1201 EYITRNALVGSGAAETLDRQQQQQQQTHASLERQARLNAQLKANGVGAGGGGASTYDSVSSYDSY 1265
            ..:..|..|                 |:.|||..|.......|:..|.
Mouse  1036 SAVNHNVSV-----------------TNVSLEEPAPAPPTSHASQPGC----------------- 1066

  Fly  1266 NNTQMAMQNLGRLGPNAPDDLKSVPNANGRPLPP-TGQSHEYGRTPHDHRSFGGPNDLNRQSSPG 1329
                        ||..:.:....|....|.|||| ...:..|.:.|:..... ..|.:.:|.:.|
Mouse  1067 ------------LGAPSAEAAHVVLRGEGPPLPPHADPAKVYRKEPYSEEMM-RQNHILKQPALG 1118

  Fly  1330 RPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRKPLVETKTDYGKYSRNNSVTQADYTKLPKTAP 1394
            .|              ...|.:..||..|  |:.|.:|.:.       :..:.|..|..
Mouse  1119 HP--------------GQRPDKEPNLAYE--PQLPYIEKQA-------SRDLEQPSYRY------ 1154

  Fly  1395 HGVVPPPNVSNGQGQMNGSGTPSSNGSGPFKPVPPPKPKNY--------RPPVQSGGSSGSGGTT 1451
                   .||:...|.:                     :||        |.|...         .
Mouse  1155 -------EVSSYTDQFS---------------------RNYDHRLRFEDRIPTYE---------D 1182

  Fly  1452 PWENGDSGSPRSPNGFYYPPTPSHHHYGQQATPGSPSNGHMQPPPPQQQQPTYGGSNGNYG--QA 1514
            .|...|...|       |.|.|..:.:.:..              ..:|.|......|.:.  :.
Mouse  1183 QWSYYDDKQP-------YQPRPFENQHPRDL--------------DSRQHPEEASERGYFQRFEE 1226

  Fly  1515 PPPQSYPQANGYNGNGHHYNGGSGTGPYIAPHRGMPPPIGNLPPHTPERHALDLAGSREQRGSAF 1579
            |.|.||.....|.                           .||..:..||       .||...|:
Mouse  1227 PAPLSYDSRTRYE---------------------------QLPRTSTLRH-------EEQPAPAY 1257

  Fly  1580 ELYRKPQIGATAGHHHNMSEMEPYDERYDDYYNMPPPAAHPSQGHHMQRSRSAPRYPHERPPHAQ 1644
            |:           |:....|.:||.       :..|.::.|.| :..|..||..:.|   ||
Mouse  1258 EV-----------HNRYRPEAQPYS-------STGPKSSEPKQ-YFDQYPRSYEQVP---PP--- 1297

  Fly  1645 DPNYYGHYGTSRGHSQPRQQYSQHHQQQYYDDHGLEMGPPPLPPHKKKKSVLKSPLVALKNALLK 1709
                  .:.:..||.:|.              ||..:.||.:|..::|..||.|
Mouse  1298 ------GFTSKTGHYEPL--------------HGAAVVPPLIPSSQQKPEVLPS----------- 1331

  Fly  1710 STRPLRRMNSMVEPERKPKGLRRQQSMLERGVQRPYYPDEYPTYPAGFEERAHGGQGMMQPHSQD 1774
            :|:|.....::.|.|..|  ..:.||:|.|...              ||
Mouse  1332 ATKPQPPPPTLTEEEEDP--AMKPQSVLTRVKM--------------FE---------------- 1364

  Fly  1775 AYYQRGGHYAPQQQEMMNSTYQNLEGEDIYGNIGNTVPRMPHHQDNGYGYDQYDLYANRACIDLE 1839
                             |....:||.:.   ::.:|....|
Mouse  1365 -----------------NKRSASLENKK---DVNDTASFKP------------------------ 1385

  Fly  1840 RRQAEAAAASGGRNGRRIVRRHSTTTADRGGNPGPPRRPMISPGYEQDPQEIYQTRNGA-YMLPD 1903
               .|.|:.                         ||...:..|  :..||..:...:.. |.||:
Mouse  1386 ---PEVASK-------------------------PPGASLAGP--KPVPQSQFSEHDKTLYRLPE 1420

  Fly  1904 QRR---APSSEVMTRRRFYPGAANEQTEEEPLYQSRREMQREMQRNHLYQSKREMQERISQGKRD 1965
            .::   .|..:::....:.|....|...::..|..||..:.:... ||.....      |:..:.
Mouse  1421 PQKPQVKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPSA-HLPAGHH------SEPAKP 1478

  Fly  1966 MEREFSPQSSSSQSEASNSEAIYQ-SRREAKESALKTRSQLRDQIYQTRREALDSMAEPIYVSKR 2029
            :..:..|..||..|:...|...|. .:|..|..  |..:...|:.:..:|........|......
Mouse  1479 VHSQSQPNFSSYSSKFLGSYTSYDYLKRNIKWG--KPETDAVDRSFSEKRYDPAQATPPPPPLPS 1541

  Fly  2030 GMGRPAPIYETREESILQSRENETDEKKEKECKTEQIQVEINAQPEEQIEDSTLSRSDLQKSSDT 2094
            ...:|||...:....|           ..|..:.|...|.::.|      :|.:|:.|...|.
Mouse  1542 QYSQPAPPLSSSSLHI-----------HSKGAQGEGNSVSLDFQ------NSYMSKPDPPPSQ-- 1587

  Fly  2095 VIENPA--RAPLVQDEVDDDEEEEVQDQRDPAESSADQTEQPTAIENNLHNEGMVEQSQNDSDDV 2157
              ..||  |.|..:|.......::....:.|. :.|:||::......|.........|....:..
Mouse  1588 --SKPATFRPPTREDPPQTFYPQKSFPDKAPV-NGAEQTQKTITPVYNRFTPKPYTSSARPFERK 1649

  Fly  2158 FEAADKVSPLAPPPAPVQPPTPRSGRAPFHISNILK--RTAPPPSSPIGDSCTSIETQYTSQASL 2220
            ||:......|.|.....:|..  |.:.|.....::|  .:..||....|....|:.|      ..
Mouse  1650 FESPKFNHNLLPSETVHKPEL--SSKTPTSPKTLMKAHSSTQPPEFDSGVETFSVHT------DK 1706

  Fly  2221 PVGPPNATSTPFSSSMSLPIAGPVNNQPSA-------NGRFPTLPREPSTSRGFFDSNGGTLADK 2278
            |....|..||       :|.|.||:  |||       :|....     :|:||.|:||||.|:..
Mouse  1707 PKYQMNNIST-------MPKAVPVS--PSAVEEDEDEDGHTVV-----ATARGIFNSNGGVLSSI 1757

  Fly  2279 LWHVSLQIPPGAIPAGVRQEIYFTVSDPRMGQAVGGPPLDMENGETMLSPLVMCGPQGLEFLVPV 2343
            ...||:.||.||||.|:.|||||.|.  |....:  ||||.|.|||:|||||||||.||:||.||
Mouse  1758 ETGVSIIIPQGAIPEGIEQEIYFKVC--RDNSIL--PPLDKEKGETLLSPLVMCGPHGLKFLKPV 1818

  Fly  2344 TLNIPHCAGRTA-SLGLALKATDSEKNLHTEWDNIDLPSN----AAAHTVSVKVDHF 2395
            .|.:||||..|. ....|||::||.......|.|..||.:    ..|:.|||.:|||
Mouse  1819 ELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF 1875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	54/84 (64%)
		PDZ_signaling	396..477	CDD:238492	33/80 (41%)
		PDZ_signaling	633..710	CDD:238492	37/78 (47%)
		SH3_ZO	729..790	CDD:212793	30/60 (50%)
		GuKc	831..1007	CDD:214504	81/177 (46%)
		ZU5	2263..2351	CDD:279170	51/87 (59%)
Tjp1	XP_006540841.1	PDZ_signaling	115..200	CDD:238492	54/84 (64%)
		PDZ	276..356	CDD:214570	34/83 (41%)
		PDZ	518..594	CDD:366185	37/75 (49%)
		SH3_ZO-1	610..674	CDD:212959	33/63 (52%)
		GuKc	708..887	CDD:214504	82/179 (46%)
		PHA03247	<1006..1705	CDD:223021	178/1092 (16%)
		PRK10263	<1227..>1403	CDD:236669	59/371 (16%)
		ZU5	1742..1841	CDD:366307	57/102 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845442
Domainoid	1	1.000	113	1.000	Domainoid score	I6130
eggNOG	1	0.900	-	-		E1_KOG3580
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	625	1.000	Inparanoid score	I865
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001438
OrthoInspector	1	1.000	-	-		otm42386
orthoMCL	1	0.900	-	-		OOG6_103390
Panther	1	1.100	-	-	O	PTHR13865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3326
SonicParanoid	1	1.000	-	-		X1692
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780