DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and magu-1

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_497201.1	Gene:	magu-1 / 190302	WormBaseID:	WBGene00021914	Length:	567	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	90/464 - (19%)
Similarity:	168/464 - (36%)	Gaps:	145/464 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   656 IFVTAVQPGSPASLQG-LMPGDKILKVNDMDMNGVT------REEAVLFLLSLQDRID---LIVQ 710
            ::|..:.....|...| :..||::|:|     ||:|      ||     ::.|.|:.|   :..:
Worm   151 VYVARIMANGVADRSGCIQEGDRVLEV-----NGITVADKEPRE-----IVKLLDKCDNGIITFK 205

  Fly   711 YCKEEYDEVVTNQRGDSFHIKTHFHCD------NP-SKGEMAFKAGDVFRVIDTLHNGVVGSWQV 768
            ....|.::.:..::....:.:..|..|      :| .:..::|:.||:..::|....   ..||.
Worm   206 LIPAEINQKLKQKKSSHRYARALFDYDPWQDKRHPCPEAAISFRGGDILEILDEKDQ---YWWQT 267

  Fly   769 LKIGRG--------HQEMQR------GVIPNKSRAEELATAQFNATKKEMNANES--------RG 811
            .|||.|        |.:..|      |::|:     |....|....:..::.::.        :|
Worm   268 RKIGFGALARRKESHDDENRDDSKKVGLVPS-----EWLQCQSEIPENGIDTSDDFQSFLENHKG 327

  Fly   812 NF----FRRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLAR 872
            .|    ||.|....||.          ||             |:|..||..|..:         |
Worm   328 RFYESVFRWRNKKKRRR----------VV-------------VLLGAPGVGRNEI---------R 360

  Fly   873 ERLAKDFPDKFST----------PLQDDDKSAATSGKCRIVRLSNIRDVMDRGKH---------- 917
            .:..|.|.|:|:.          |.:.|..:...:.:..:.|:...:::::.|:.
Worm   361 RQFFKVFADRFTNAIPHTSRPQRPNESDGVNYYFTSRSEMERMIERKEMLEYGEFRDNLYGTALK 425

  Fly   918 ----------ALLDITPNAVDRLNYAQFYPVVIFLKT----DSKHVIKQLRHGLPKAAHKSSKKL 968
                      .||...|.|::.:...:|.|:|||::.    :.||..:..|....::...:|...
Worm   426 SVRKASEKGTVLLTPHPLAIENIRTWEFAPIVIFVQPPEFGEFKHTREVYRSQTTRSHSAASSSN 490

  Fly   969 LEQ---CQKLERVWSHIFSTQIA--LSDEESWYRKLRDSI----DL-----QQSGAVWMSESK-- 1017
            :.|   .....|.:|.:...||.  .:..|..||...|:|    ||     :.:|.::..|||
Worm   491 ISQNTAATSAARAFSDVEIRQIIDNSAQMEQKYRGYCDAIIRNVDLDTTMNELTGLIYQLESKAT 555

  Fly  1018 --PVESLSD 1024
              |::.|.|
Worm   556 WMPMKWLDD 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492	15/63 (24%)
		SH3_ZO	729..790	CDD:212793	17/81 (21%)
		GuKc	831..1007	CDD:214504	41/223 (18%)
		ZU5	2263..2351	CDD:279170
magu-1	NP_497201.1	PDZ_signaling	128..201	CDD:238492	15/59 (25%)
		SH3_MPP	224..300	CDD:212796	17/83 (20%)
		Guanylate_kin	348..550	CDD:279019	39/210 (19%)
		NK	353..543	CDD:302627	36/198 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910