DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and dlg-1

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	NP_001024431.1	Gene:	dlg-1 / 180819	WormBaseID:	WBGene00001006	Length:	967	Species:	Caenorhabditis elegans

Alignment Length:	1063	Identity:	235/1063 - (22%)
Similarity:	403/1063 - (37%)	Gaps:	337/1063 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 EQQQLGRRKAAAAAEINLANQVYWL--GKQKTRSR-SRSNSVGNRSITSCM-------------- 179
            ||..|..||:.|...:.:...:..|  |.....|| :.:.|..|.:::|..
Worm    58 EQTLLSERKSDAEKNMEVRRVIERLEGGPHSYNSRPAATTSTSNYNLSSTTPLISDLRDRGGFSY 122

  Fly   180 --GGGGGGGEKERERGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETASTHSSSQRRRFKKGD 242
              |||.|.|                        ||...|....|:...::|||...:|:|....|
Worm   123 LNGGGLGNG------------------------LGNGLGNGLLSSPYNSSSTHYLHERQRQTSHD 163

  Fly   243 RT-------------------------------TWEYHTVAVTRVPGY-GFGIAVSGGRDNPHFA 275
            .|                               .||...:.:.:  |: |.|.:::||.|.| ..
Worm   164 GTWRETTTRTVDTPSGLERRVVEHTGVIDDHGRKWELENIVLEK--GHTGLGFSITGGMDQP-TE 225

  Fly   276 NGDPSIAVSDVLKGGP--AEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRR-- 336
            :||.||.|:::::||.  |:.|::.||.|.:||..:.|||::..||..|:.|||.|.|.:|||
Worm   226 DGDTSIYVTNIIEGGAALADGRMRKNDIITAVNNTNCENVKHEVAVNALKSSGNVVSLSLKRRKD 290

  Fly   337 ---VPL---------------NPINAAGAVQHQ-HSHSLSSVGLMANGSGGVAPTPIT-----SL 377
               :|:               .|..:||.:||. ||           .|..:.|.|..     ||
Worm   291 EAFLPIGGNFGGSTSYLRSGVTPSVSAGNLQHAIHS-----------PSAPIHPPPPPPVHHGSL 344

  Fly   378 SQ----------PNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLG-CRLFVKEISSKAREQL 431
            ||          ||:....||:.| .|....:.   ||:.:::  |.| ..::|.:|..:...:|
Worm   345 SQLSVGQYRSTRPNTSVIDLVKGA-RGLGFSIA---GGQGNEH--VKGDTDIYVTKIIEEGAAEL 403

  Fly   432 NANGYSLQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSAS 496
            :..   |:.||.|..:.:.:..:| :.:.|..::.....|:.|::
Worm   404 DGR---LRVGDKILEVDHHSLINT-THENAVNVLKNTGNRVRLLI-------------------- 444

  Fly   497 HQASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKS 561
            .|.:|.|:             |::....::|           ..|..|.|:..:.|.:.:..: |
Worm   445 QQGTGAIF-------------NDSASQQFMP-----------TTPILRPSSVQDYNRSQMGSQ-S 484

  Fly   562 NLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPP-PRGSSGGAAQEDFYSSRRQLY 625
            :|:    ..||:....|.|   .|:        ||...|||.. .:|.:|
Worm   485 HLS----YGGPLNTSYSSQ---API--------AIPLEPRPVQLVKGQNG--------------- 519

  Fly   626 EERQSAEPRFISFQKEGSVGIRLTGG--NEAGIFVTAVQPGSPASLQG-LMPGDKILKVNDMDMN 687
                              :|..:.||  ||. |:::.|.||..|.|.| :..||.:|:||.:.:.
Worm   520 ------------------LGFNIVGGEDNEP-IYISFVLPGGVADLSGNVKTGDVLLEVNGVVLR 565

  Fly   688 GVTREEAVLFLLSLQDRIDLIVQYCKEEY-----------DEVVTNQR-----GDSFHIKTHFHC 736
            ..|.:||...|.:..:.:.|.:||..:||           ::|:...|     ..|.:::..|..
Worm   566 NATHKEAAEALRNAGNPVYLTLQYRPQEYQIFESKIEKLRNDVIAQSRMGTLSRKSEYVRALFDY 630

  Fly   737 DNPSK-------GEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEE--- 791
            | ||:       ..|.|..||:..:|::..:   ..|...|:....:|...||||:|.|.|:
Worm   631 D-PSRENSVAPHRSMGFNYGDILHIINSSDD---EWWTARKVHENGEETAEGVIPSKKRVEKRER 691

  Fly   792 LATAQ--FNATKKEMNANESRGNFFRRRRSTHRRS--------KSLSRENWDDVVFSDSISKFP- 845
            |...|  ||:..:.:..|.|......||.|..:.|        ||..|.| |....|.::::.|
Worm   692 LRRKQVNFNSGSQSLGRNSSTTGLENRRGSRSQLSFSRKFPFVKSTDRLN-DLNEESSNVAEEPV 755

  Fly   846 -AYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFST------------------------ 885
             :|:.|..:...:||||::.|.:.|...:.|....|.|||:
Worm   756 WSYQAVEQQAINYVRPVIILGALKDRINDELVNRDPSKFSSCVPHTSRPPREGEVNGRDYYFVNK 820

  Fly   886 -PLQDDDKS-------------AATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRL-NYAQF 935
             .:::|.|:             ..||       :.::|||.::|:|.:||::.||:.|| :.|..
Worm   821 HNMEEDVKNNLFIEAGQFQNNLYGTS-------IQSVRDVANQGRHCILDVSGNAIRRLQSNANI 878

  Fly   936 YPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLL---------EQCQKLERVWSHIFSTQIA-LS 990
            .|:.||:|..|...|.:|...|  |.::...:.:         .:|.::|:.:..:|:.:|: :.
Worm   879 QPISIFIKPSSAQQILELDSQL--ATNRQDDRAMSGEEAQAQYSRCHRIEQTFGDLFTQEISNVH 941

  Fly   991 DEESWYRKLRDSIDLQQSGAVWM 1013
            .......|:...|..:....:|:
Worm   942 SANDVLSKVYSIISRESQTPIWV 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	32/87 (37%)
		PDZ_signaling	396..477	CDD:238492	15/81 (19%)
		PDZ_signaling	633..710	CDD:238492	22/79 (28%)
		SH3_ZO	729..790	CDD:212793	18/67 (27%)
		GuKc	831..1007	CDD:214504	48/226 (21%)
		ZU5	2263..2351	CDD:279170
dlg-1	NP_001024431.1	L27_1	7..63	CDD:312556	2/4 (50%)
		PDZ	199..289	CDD:214570	35/92 (38%)
		PDZ_signaling	361..445	CDD:238492	19/113 (17%)
		PDZ	507..591	CDD:214570	29/117 (25%)
		SH3_DLG-like	623..684	CDD:212795	16/64 (25%)
		GuKc	776..944	CDD:214504	36/176 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910