DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyd and par-3

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:NP_001293669.1 Gene:par-3 / 175783 WormBaseID:WBGene00003918 Length:1533 Species:Caenorhabditis elegans


Alignment Length:1840 Identity:353/1840 - (19%)
Similarity:539/1840 - (29%) Gaps:690/1840 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   167 SNSVGNRSITSCMGGGGGGGEKERERGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETASTHS 231
            |.|..:.|.|||..||...|..:....|:      ..:...:|..|...|..|:|     .||..
 Worm     2 SASSTSSSSTSCPEGGEPSGSCKSSDEGE------STLKKRMQQYGIASGYANSS-----ISTLD 55

  Fly   232 SSQ--------RRR-------------FKKGDRTTWEYHTVAV------------TRVPGYGFGI 263
            .||        .||             :|:.|:|..:....|:            .|:..:....
 Worm    56 RSQYQSLPLNGTRRVTVQFGRMKIVVPWKESDQTVGQLADAALLRYKKARGMANEDRIHVHRLEC 120

  Fly   264 AVSGG-------RDNPHFANGDPSIAVSDVLKGG---PAEDRLQVNDRIISVNGVSLENVEYATA 318
            |..||       .:.....|.|..:|::|...||   |...::|....            .||..
 Worm   121 ASDGGILDMDDVLEEVFDLNYDQILAITDEANGGSTTPTYSQIQKQQH------------HYAQP 173

  Fly   319 VQVLR--DSGNTVQLVVKRRVPLNPI-NAAGAVQHQH-SHSLSS---VGLMANGSGGVAPTPITS 376
            :...|  |.|           |..|| :|.|:|...| :|..:|   ||...:.|...||.|..|
 Worm   174 LPYARKFDGG-----------PSTPIASAFGSVTVNHQAHRAASPYNVGFARSNSRDFAPQPTHS 227

  Fly   377 LSQPNSL--NSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQ 439
            ..:.:|:  .||..|...||  ::|:..|..                                  
 Worm   228 KERRDSVVEVSSFDQIPQSG--LRVSTPKPS---------------------------------- 256

  Fly   440 EGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIY 504
                               ::::.:|||  :.:|..:||.          :|...||...:....
 Worm   257 -------------------RQSEDVIDG--KPMNQPILRS----------SLRTEASGSRTEEAT 290

  Fly   505 ATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPR--- 566
            ...|.:|:........|.:   ........:..|.:.|.|.:.|        :|.||.:|..   
 Worm   291 PVKQSRVTLSPEVEKKLAE---QDERKSERRKHYDKNPGRFARG--------SDRKSRITDALLD 344

  Fly   567 GRSRGPIMDGVSLQQLDRPVTPTRGR--SAAIDEPPRP-------PP-PRGSSGGAAQEDFYSSR 621
            .|.|  |.|.:..|   .|...|:.:  ...||:.|.|       || |..|          .:.
 Worm   345 ARDR--IADQLESQ---NPAEETKSQMIRVKIDQGPMPGTSLVTFPPIPEKS----------ENE 394

  Fly   622 RQL-------YEERQ----SAEPRFIS----FQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQG 671
            :||       ::|..    ::||..:|    .:.|....|...|....|..:.|:. |.|.....
 Worm   395 KQLGIEVNAVFDESSELPGTSEPTKLSSVQIMKIEDGGRIAKDGRIRVGDCIVAID-GKPVDQMS 458

  Fly   672 LMPGDKILKVNDMDMNGVTREEAVLFL-LSLQD---------RIDLIVQYCKEEY------DEVV 720
            ::.    ::.:..|:..||.....|.: .||:.         .|...:|....:|      .|::
 Worm   459 IIR----VRASISDLAAVTSRPVTLIINRSLESFLEQESSAKPIQSALQQANTQYIGHTTVVELI 519

  Fly   721 TNQRGDSFHIKTHFHCDNPSKGEMAF---------------KAGDVFRVIDTLHNGV-VGSWQVL 769
            .:..|..|.:...    ..:|||..|               |:||  |:::.  ||. .|.|...
 Worm   520 KSSNGFGFTVTGR----ETAKGERLFYIGTVKPYGVALGHLKSGD--RLLEI--NGTPTGQWTQS 576

  Fly   770 KIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRRRSTHRRSKSLSRENWDD 834
            :|                 .|:|         ||....|.......|...:...|.|.|.||.: 
 Worm   577 EI-----------------VEKL---------KETMVGEKIKFLVSRVSQSAIMSTSASSENKE- 614

  Fly   835 VVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFP-------DKFS--TPLQDD 890
               ::...|....|::..:.|   .|.::..||        .||.|       .:|.  .|..:.
 Worm   615 ---NEETLKVVEEEKIPQKLP---LPALMTPPV--------PKDTPALSPSGASRFEIVIPFING 665

  Fly   891 DKSA--ATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQL 953
            ..||  ..|.|.|:.:.||       |.                          |.|....||.:
 Worm   666 SSSAGLGVSLKARVSKKSN-------GS--------------------------KVDCGIFIKNV 697

  Fly   954 RHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAVWMSESKP 1018
            .||  .||.|.....::     :|:        :.:.|.:      .:.:|.:::.|....:.|.
 Worm   698 MHG--GAAFKEGGLRVD-----DRI--------VGVEDID------LEPLDNREAQAALAKKLKE 741

  Fly  1019 VESLSDDFLFPMTTSRLSYASSPESDLEL--------SPGPSASLSLGNLPQLVKASSDPSIATN 1075
            |..:|.:  ..:|.||.:..:..:...:|        ||.||:.:|....|.    |..||.|| 
 Worm   742 VGMISSN--VRLTISRYNECNPGQISRDLSRITVDASSPSPSSRMSSHTAPD----SLLPSPAT- 799

  Fly  1076 QDNLDRDRDIIGEGLPPPYT--VPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGVGGDTA 1138
                   |.....|....::  .....||||.|.|....||                  :..|..
 Worm   800 -------RGTSSSGADSSHSRQSSASSAVPAVPARLTERDS------------------IVSDGT 839

  Fly  1139 AVRPQSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRNGTLGRSAQERLFGKAVVQDDVQAEYI 1203
            :...:|       :||...|        |.|..|       |||.:.....|.....|....:..
 Worm   840 SRNDES-------ELPDSAD--------PFNREG-------LGRKSLSEKRGMGAAADPQHIKLF 882

  Fly  1204 TRNALVGSGAAETLDRQQQQQQQTHASLERQARLNAQLKANGVGAGGGGASTYDSVSSYDSYNNT 1268
            .........:|.|...|::.:.|..:|.:|..|...:|......|....::...::...|..|..
 Worm   883 QDIKHQRQNSAPTSSTQKRSKSQPRSSSQRNYRSPMKLVDLPTTAAASASTNSQNLDDSDMLNRR 947

  Fly  1269 QMAMQNLGRLGPNAPDDLKSVPNANGRPLPPTGQSHE----YGRTPHDH---------------- 1313
            ..:|:::.|       .::|:....|:  .|||.|.:    ...:|..|                
 Worm   948 SQSMESINR-------PVESILRGTGQ--IPTGSSSKVQFMQAASPDQHPFPPGAALLRLKNEES 1003

  Fly  1314 RSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRKPLVETKTDYGKYSRN 1378
            ||    .|.:|:.|.|.|    .:|.||.                           ..:|..||:
 Worm  1004 RS----RDKSRRKSMGNP----FSAMRNF---------------------------FGFGSKSRD 1033

  Fly  1379 NSVTQADYTKLPKTAPHGVVPPPNVSNGQGQMNGSGTPSS------NGSGPFKPVPPPKPKNYRP 1437
            .|         |:..|...|          |:.....|.|      |||.  :..|||     .|
 Worm  1034 AS---------PEKTPTESV----------QLRSVERPKSIIDERNNGSS--ERAPPP-----LP 1072

  Fly  1438 PVQSGGSSGSGGTTPWENGDSGSPRSPNGFYYPPTPSHHHYGQQATPGSPSNGHMQPPPPQQQQP 1502
            |.|| ...||||..   ..|.|.|       |...|.:.|...:....|..||        .:..
 Worm  1073 PHQS-QRRGSGGNV---FVDYGEP-------YGLIPQYPHNTSKIMATSAQNG--------IRLI 1118

  Fly  1503 TYGGSNGNYGQAPPPQSYPQANGYNGNGHHYNGGSGTGPYIAPHRGMPPPIGNLPPHTPERHALD 1567
            :|   ..|...:|||                                |||.|.|.|       |.
 Worm  1119 SY---TKNQSSSPPP--------------------------------PPPAGGLSP-------LQ 1141

  Fly  1568 LAGSR----------EQRGSAFELYRKPQIGAT----------AGHHHNMSEMEPYDERYDDYYN 1612
            |..|:          .||....::.|.|.:.:|          .|...:|......|.|.     
 Worm  1142 LGNSKFYSSYREPSITQRPRLPDMSRTPTLSSTIDTRPIAITRVGAQSSMKTNTFTDNRV----- 1201

  Fly  1613 MPPPAAHPS--------QGHHMQRSRSAPRYPH-----------ER-----PPHAQD-------- 1645
              |...|.|        ...|:.|:.|.|.|.|           ||     ||:...        
 Worm  1202 --PAVIHRSTRRPMSTMDYQHLMRTMSVPEYHHKPPVEVSRKPVERCVVSIPPNTMKTSPTINKF 1264

  Fly  1646 PNYYGHYG---------------TSRG-------HSQPRQQYSQHHQQQYYDDHGLEMGPPPLPP 1688
            ||......               ::||       .|.|.:..|.....:.|       |..||.|
 Worm  1265 PNNQRDINRVAVVDVVTPTTITCSTRGSRTLAVEQSAPLRSSSPRTDHRRY-------GSQPLRP 1322

  Fly  1689 HKKKKSVLKSPLVALK--------NALLKSTRPL--RRMNSMVEPERKPKGLRRQQSMLERGVQR 1743
            ..:......||.|..:        .||.....||  .::.|.:...|..:.|..:.||::|    
 Worm  1323 SNEANRSSSSPSVVRRPRPLTVGDGALRVEPLPLDHHQLGSNMPRRRSMRMLDLENSMVDR---- 1383

  Fly  1744 PYYPDEYPTYPAGFEERAHG 1763
               ||..      |::.|.|
 Worm  1384 ---PDSL------FQDTAVG 1394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 18/108 (17%)
PDZ_signaling 396..477 CDD:238492 6/80 (8%)
PDZ_signaling 633..710 CDD:238492 16/90 (18%)
SH3_ZO 729..790 CDD:212793 13/76 (17%)
GuKc 831..1007 CDD:214504 32/186 (17%)
ZU5 2263..2351 CDD:279170
par-3NP_001293669.1 DUF3534 68..216 CDD:288873 34/170 (20%)
PDZ_signaling <423..481 CDD:238492 11/62 (18%)
PDZ_signaling 513..595 CDD:238492 21/115 (18%)
PDZ_signaling 663..753 CDD:238492 24/145 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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