DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyd and zoo-1

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:NP_001252376.1 Gene:zoo-1 / 173316 WormBaseID:WBGene00013683 Length:1163 Species:Caenorhabditis elegans


Alignment Length:1472 Identity:391/1472 - (26%)
Similarity:579/1472 - (39%) Gaps:418/1472 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 TWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVS 309
            ||:..:|::.|....|||||:|||||||||.:|||.:.:|||:..|||...|||||||:|.|.||
 Worm    40 TWQLLSVSLHRAANLGFGIAISGGRDNPHFTSGDPVVVISDVVPNGPAWGLLQVNDRILSANQVS 104

  Fly   310 LENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSLSSVGLMANGSGGVAPTPI 374
            .||:||::||.::::..: :.::|||||.:                                 |:
 Worm   105 FENIEYSSAVDIIKNKDH-IDMIVKRRVAV---------------------------------PM 135

  Fly   375 TSLSQPNSLNSSLVQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQ 439
            ....|               :.:|.||:|..||||:|:|:||:.::|||.:   .:|......|:
 Worm   136 LEYEQ---------------RTLKFTLSKSRKKDDFGIVVGCKFYIKEIRN---PKLAEKDPGLK 182

  Fly   440 EGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIY 504
            |||.:.||:..:. :..||:|..|.::..:::|.||:.||:...|  |:....|:. ::..|::.
 Worm   183 EGDSVLRINGQSL-EGASLEEVNKWLERSRDKLCLVIQRDVRRGT--SRWPSQNTV-YERVGSVA 243

  Fly   505 AT--HQPQVSGCSSSNNNLEDPYLPG-GASYSSQNLYVQPPTRTSNGPNIN---GNGLNDEKSNL 563
            ||  |.|             .|.||. ..:..:.:.||..|...|:| ::.   .:..|.:.||.
 Worm   244 ATPRHSP-------------SPMLPHMPITQRNSHEYVNSPRHRSDG-SVERRVSSPANSQLSNF 294

  Fly   564 TPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEER 628
            .....|:      ::.|..|   ..||..|.:||           :.|.|.              
 Worm   295 NGMASSQ------ITTQDYD---CYTRQPSRSID-----------ANGVAN-------------- 325

  Fly   629 QSAEPRFISFQK-EGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTRE 692
                   |.|:| .||||:|:.||||.||||:||...|||||.|:..||:||:||..:|.|||||
 Worm   326 -------IMFRKVGGSVGVRVIGGNEVGIFVSAVAADSPASLHGVSCGDRILEVNGRNMRGVTRE 383

  Fly   693 EAVLFLLSLQDRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKG---EMAFKAGDVFRV 754
            .||..||.|.||:.|.:::.:::::.|..||.||:|:|::||..:...|.   |::...||:|.|
 Worm   384 SAVQLLLGLDDRVSLRLEHARQDFEHVRANQLGDNFYIRSHFSREKRDKASPLELSINEGDIFHV 448

  Fly   755 IDTLHNGVVGSWQVLKI---GRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRR 816
            .|||..|.||.||..::   .....|..:|||||::.||::| .::....:...|.........|
 Worm   449 TDTLFGGTVGLWQAARVYSSSENKGEPVKGVIPNQATAEQIA-KEWRVYVEAKQAKSGGSGTLLR 512

  Fly   817 RRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPD 881
            |:...||:|||.:....|.  ::.....||||||.|..|.|.||||||||::|:||.:|...|..
 Worm   513 RKFESRRTKSLPKNMICDP--TELNLPLPAYERVALNTPSFHRPVVLFGPLADIARHQLLTQFSA 575

  Fly   882 KFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDS 946
            :|.:|..|..          ::|||::..|:...||.:|||:..:|:||..||:.|:|:||..|.
 Worm   576 RFGSPESDGG----------VIRLSSVDHVIASMKHCVLDISIESVERLQLAQYAPIVVFLDVDG 630

  Fly   947 KHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQSGAV 1011
            :..|:::|... .|.|.||:||.|...::::..||:.|..|..:.|..|:..||:.|...|...:
 Worm   631 RSKIREIRKKC-NAPHLSSRKLAENGNQIKKHHSHLLSATIDATHETGWFDALRELIGHLQQRRL 694

  Fly  1012 WMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSDPSIATNQ 1076
            ||.|..|...|.|..|||:          |:.|             |::..|.....|     .|
 Worm   695 WMPEFPPNLPLEDVLLFPL----------PKWD-------------GDVDSLKSEYVD-----YQ 731

  Fly  1077 DNLDRDRDIIGEGL--PPPYTVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGVGGDTAA 1139
            |:|.|..   ||..  ..|...|.|  :|:......||             |:.|...:|.|   
 Worm   732 DSLPRKG---GEKKWDSSPLQTPGD--LPSEMREYSTM-------------PRPQHHQLGQD--- 775

  Fly  1140 VRPQSLYGINAPDLPPRIDRQSKPGDIPLN---TSGSSS----------RNGTLGRSAQERLF-- 1189
                  :|.|.       :|||......|:   |:.|||          |:.:..|:.....:  
 Worm   776 ------FGGNR-------NRQSSNSQSTLSTFVTTASSSNPPRPLLTPTRDESASRTTTPHGYYH 827

  Fly  1190 GKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLERQARL-----NAQLKANGVGAG 1249
            .|.::.||                                ||.:.|||     ||:|:       
 Worm   828 VKQLLDDD--------------------------------SLYQDARLANEIANARLR------- 853

  Fly  1250 GGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRPLPPTGQSHEYGRTPHDHR 1314
                            ...::..:.:               |.....|.|:...|....|...:.
 Worm   854 ----------------EEAKLREERV---------------NRQRSELSPSNMQHRLDNTTPSNF 887

  Fly  1315 SFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRKPLVETKTDYGKYSRNN 1379
            .|.                       |:.|.|..|                    ...|:|    
 Worm   888 DFS-----------------------NVQPSNSNP--------------------VPNGRY---- 905

  Fly  1380 SVTQADYTKLPKTAPHGVVPPPNVSNGQGQMNGSGTPSSNGSGPFKPVPPPKPKNYRPPVQSGGS 1444
                           |.:.|....|      :.||...:.|.|..:..|||:|    |||.||.|
 Worm   906 ---------------HPLTPSSMTS------SSSGASRTAGQGQQQTAPPPRP----PPVNSGNS 945

  Fly  1445 S---GSGGTTPWENGDSGSPRSPNGFYYPPTPSHHHYGQQATPGSPSNGHMQPPPPQQQQPTYGG 1506
            |   .|.....|.|..:...|.......|..|:.       |.||.|..:..........|| |.
 Worm   946 SPYTQSYIRNKWNNDGAMDARGAENQTPPVVPAR-------TNGSASPANASISLTVSNVPT-GS 1002

  Fly  1507 SNGNYGQAPPPQSYPQANGYNGNGHHYNGGSGTGPYIAPHRGMPPPIGNLPPHTPERHAL--DLA 1569
            |..:  ::|.|:.....||.......                        |....|..||  .|.
 Worm  1003 SIAS--KSPTPRLDENENGQKSEEEE------------------------PTVVEESTALIGSLG 1041

  Fly  1570 GSREQRGSAFELYRKPQIGATAGHHHNM-------SEMEPYDERYDDYYNMPPPAAHPSQGHHMQ 1627
            |......|..|| |.|....|.|..|.:       .:..|.|....:....|.....| ||...:
 Worm  1042 GVIRCEKSNVEL-RIPAGAITEGQEHEIYVKVCREGDSSPIDRSKGETLLSPLVMCGP-QGLKFE 1104

  Fly  1628 RSRSAPRYPHERPPHA-QDPNYYGHYGTSRG----HSQPRQQ 1664
            : :...|.||..|..| .|..:.....|..|    |.:..||
 Worm  1105 K-QCELRMPHTGPVTADSDGQWSFSLKTGEGGEWKHMEIEQQ 1145

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 42/84 (50%)
PDZ_signaling 396..477 CDD:238492 29/80 (36%)
PDZ_signaling 633..710 CDD:238492 44/77 (57%)
SH3_ZO 729..790 CDD:212793 23/66 (35%)
GuKc 831..1007 CDD:214504 63/175 (36%)
ZU5 2263..2351 CDD:279170
zoo-1NP_001252376.1 PDZ_signaling 46..128 CDD:238492 42/82 (51%)
PDZ_signaling 146..219 CDD:238492 28/76 (37%)
PDZ_signaling 326..401 CDD:238492 44/74 (59%)
SH3_ZO 420..487 CDD:212793 23/66 (35%)
NK 539..690 CDD:418433 62/161 (39%)
ZU5 1033..1133 CDD:395639 25/102 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160159337
Domainoid 1 1.000 94 1.000 Domainoid score I4728
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 465 1.000 Inparanoid score I858
Isobase 1 0.950 - 0 Normalized mean entropy S6759
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1175136at2759
OrthoFinder 1 1.000 - - FOG0001438
OrthoInspector 1 1.000 - - oto18547
orthoMCL 1 0.900 - - OOG6_103390
Panther 1 1.100 - - LDO PTHR13865
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3326
SonicParanoid 1 1.000 - - X1692
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1312.880

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