DRSC/TRiP Functional Genomics Resources

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Protein Alignment pyd and Grip2

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:NP_612544.2 Gene:Grip2 / 171571 RGDID:621668 Length:1043 Species:Rattus norvegicus


Alignment Length:1335 Identity:246/1335 - (18%)
Similarity:414/1335 - (31%) Gaps:537/1335 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 GGGEKERERGGDRDRP--------------YIRNVD-------------DLLQALGKR------- 214
            ||.:|:.:......||              |||:|:             .||:.:|:|       
  Rat    70 GGTDKDGKPRVSNLRPGGLAARSDLLNVGDYIRSVNGIRLTRLRHDEIITLLKNVGERVVLEVEY 134

  Fly   215 ----DGGDNNSNLLETASTHSSSQRRRFKKGDRTTWEYHTVAVTRVPGYGFGIAVSGG-RDNPHF 274
                ...:||..::......|     .:|:|:                 .||..:.|| .::.|.
  Rat   135 ELPPPAPENNPRIISKTVDVS-----LYKEGN-----------------SFGFVLRGGAHEDLHK 177

  Fly   275 ANGDPSIAVSDVLKGGPA--EDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRV 337
            :.   .:.::.|..||||  |..|:|.||::|::|:.|....:|||:..|:...:.....|:   
  Rat   178 SR---PLVLTYVRPGGPADREGSLKVGDRLLSIDGIPLHGASHATAIATLQQCSHEALFQVE--- 236

  Fly   338 PLNPINAAGAVQHQHSHSLSSVGLMANGSG----GVAPTPITSLSQPNSLNSSLVQNASSGQPIK 398
                            :.:::...:||.||    .:|.||                    |..:.
  Rat   237 ----------------YDVATPDTVANASGPLVVEIAKTP--------------------GSALG 265

  Fly   399 VTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAKK 463
            ::||.|..::...:.:. |:       |....::.:| :|..||.|..|..|:. :..||.||.|
  Rat   266 ISLTTGSHRNKPAITID-RI-------KPASVVDRSG-ALHAGDHILAIDGTST-EHCSLVEATK 320

  Fly   464 IIDGCKERLNLVVL------RDITNQTAVSQLNLNNSAS-HQASGNIYATHQPQVSGCSSSNNNL 521
            ::....|::.|.:|      |.:....||   .:..|.. |.....:.:.|.|:.|.|.:..   
  Rat   321 LLASVTEKVRLEILPAPQSRRPLKPPEAV---RIQRSEQLHHWDPCVPSCHSPRPSHCRAPT--- 379

  Fly   522 EDPYLPGG--ASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDR 584
               :.|||  .|.|..:.....||.....|..|.:.|        |||                 
  Rat   380 ---WAPGGQDQSRSVSSTPFSSPTMNPAFPCANASTL--------PRG----------------- 416

  Fly   585 PVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAEPRFISFQKEG------- 642
                             |..||.::|         .|||..:|.:|:.....|....|       
  Rat   417 -----------------PMSPRTTAG---------RRRQRRKEHRSSLSLASSTVGPGGQIVHTE 455

  Fly   643 ------------SVGIRLTGGNEAGIFVTA----------VQPGSPASLQGLMP-GDKILKVNDM 684
                        ..|::|.|    |||.|.          ::|.|||...||:. ||::|.:|.:
  Rat   456 TTEVVLCGDPLSGFGLQLQG----GIFATETLSSPPLVRFIEPDSPAERCGLLQVGDRVLAINGI 516

  Fly   685 DMNGVTREEAVLFL--LSLQDRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFK 747
            .....|.|||...|  .:|..::.|.:::   :..|.|....| :||:|                
  Rat   517 ATEDGTMEEANQLLRDAALARKVVLEIEF---DVAESVIPSSG-TFHVK---------------- 561

  Fly   748 AGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKE----MNANE 808
                                               :| |.|..||.....:|::|.    :.::.
  Rat   562 -----------------------------------LP-KRRGVELGITISSASRKRGEPLIISDI 590

  Fly   809 SRGNFFRRRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARE 873
            .:|:...|..:.....|.|:.:|                  :.|.|......|.:.....||.:.
  Rat   591 KKGSVAHRTGTLEPGDKLLAIDN------------------IRLDHCPMEYAVQILRQCEDLVKL 637

  Fly   874 RLAKDFPDKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPV 938
            ::.||..:.     .:.:.|.|.|....:.|..           ..|.||.:..:.    .|.|:
  Rat   638 KIRKDEDNS-----DEQESSGAVSYTVELKRYG-----------GPLGITISGTEE----PFDPI 682

  Fly   939 VIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSI 1003
            :|              .||.|      :.|.|:...:     |:....:|::......|.|.::|
  Rat   683 II--------------SGLTK------RGLAERTGAI-----HVGDRILAINSVSLKGRPLSEAI 722

  Fly  1004 DLQQSGAVWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASS 1068
            .|.|  ....:.:..::...|..|.|..:..||.||..:.|      |..:|..|.|        
  Rat   723 HLLQ--VAGETVTLKIKKQLDRPLLPRQSGSLSEASDVDED------PPEALKGGLL-------- 771

  Fly  1069 DPSIATNQDNLDRDRDIIGEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGV 1133
                                      |..:..|||       ::||:..| :|::.    .:.|.
  Rat   772 --------------------------TTHFSPAVP-------SVDSAVES-WGSSA----TEGGF 798

  Fly  1134 GGD--------TAAVRPQ----SLYGINAPDLPPRIDRQS-KPGDIPLNTSGSSSRNG------- 1178
            ||.        ..:|.||    |....:.|.|.||  |.| .||  |.:.|......|       
  Rat   799 GGSGSYTPQVAVRSVTPQEWRSSRLKSSPPPLEPR--RTSYTPG--PTDESFPEEEEGDWEPPMS 859

  Fly  1179 -TLGRSAQE---RLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLERQARLNA 1239
             ..|.:.:|   |:.|:|:  :|:::          .|.:|.|       ::..||:.       
  Rat   860 PAPGPAREEGFWRVLGEAL--EDLES----------CGQSELL-------RELEASIM------- 898

  Fly  1240 QLKANGVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRP-LPPTGQS 1303
                         ..|..||:                               .:||| ..|..:|
  Rat   899 -------------TGTVQSVA-------------------------------VDGRPGSRPWRRS 919

  Fly  1304 HEYGRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRKPLVET 1368
            .|.|.:|.|.:....|                            ||.....:.|...|      .
  Rat   920 REVGTSPEDLQELLLP----------------------------TPLEMHRVTLHKDP------V 950

  Fly  1369 KTDYGKYSRNNSVTQADY---TKLPKTAPHGVVPP 1400
            :.|:|....:..:.:..|   .::...|.||.:.|
  Rat   951 RNDFGFSVSDGLLEKGVYVHTVRIDGPAQHGGLQP 985

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 22/87 (25%)
PDZ_signaling 396..477 CDD:238492 19/80 (24%)
PDZ_signaling 633..710 CDD:238492 26/108 (24%)
SH3_ZO 729..790 CDD:212793 5/60 (8%)
GuKc 831..1007 CDD:214504 29/175 (17%)
ZU5 2263..2351 CDD:279170
Grip2NP_612544.2 PDZ_signaling 51..133 CDD:238492 13/62 (21%)
PDZ_signaling 153..236 CDD:238492 25/107 (23%)
PDZ_signaling 251..334 CDD:238492 23/112 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 371..450 26/135 (19%)
PDZ_signaling 456..544 CDD:238492 24/91 (26%)
PDZ_signaling 557..640 CDD:238492 20/152 (13%)
PDZ_signaling 657..737 CDD:238492 19/121 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 745..769 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 786..863 20/85 (24%)
PDZ_signaling 941..1020 CDD:238492 9/51 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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