DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pyd and AgaP_AGAP000255

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_003436953.1	Gene:	AgaP_AGAP000255 / 1272003	VectorBaseID:	AGAP000255	Length:	939	Species:	Anopheles gambiae

Alignment Length:	1047	Identity:	225/1047 - (21%)
Similarity:	375/1047 - (35%)	Gaps:	354/1047 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 AGEYLASEQQQQQQQQQQQHQQVQEQQQLGRRKAAAAAEINLANQVYWLGKQKTRSRSRSNSVGN 172
            |.|....:||:|:|||||..||.|:|||       |..::.|..::
Mosquito    89 ANEANRIKQQEQEQQQQQLQQQQQQQQQ-------APPQLQLQQEI------------------- 127

  Fly   173 RSITSCMGGGGGGGEKERERGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETASTHSSSQRRR 237
                          ||:                                .::|..|...::.:
Mosquito   128 --------------EKQ--------------------------------PIIELPSPRLTTTK-- 144

  Fly   238 FKKGDRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPA--EDRLQVND 300
             ..|| :.|||..:.:.| ...|.|.:::||.||||. |.|.||.::.|:.||.|  :.||||||
Mosquito   145 -LNGD-SPWEYDEITLIR-GSTGLGFSIAGGTDNPHI-NLDASIYITKVIPGGAAHVDGRLQVND 205

  Fly   301 RIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVPLNPINAAGAVQHQHSHSL-SSVGLMAN 364
            .|::||.|.:.||.:..||..|:.:|:.|.|.::|:.|     .|.|.:.:....| .|.||..:
Mosquito   206 CIVAVNEVRVVNVTHGEAVDALKQAGDRVTLHIRRKRP-----PAQAPKLEEIELLKGSKGLGFS 265

  Fly   365 GSGGVAPTPITSLSQPNSLNSSLVQNASSGQPIKVT-LTKGGKKDDYGVVLGCRLFVKEISSKAR 428
            .:||:..                 |:......|.|| :.:||.....|     ||.|
Mosquito   266 IAGGIGN-----------------QHIPGDNGIYVTKIMEGGAAHIDG-----RLAV-------- 300

  Fly   429 EQLNANGYSLQEGDIITRIHNTNCG----DTMSLKEAKKIIDGCKERLNLVV-----LRDITNQT 484
                        ||.:..:...:.|    :.:..:||...:.....|..|:|     |:.:.|
Mosquito   301 ------------GDKLIAVRTPDGGERNLENVVHEEAVATLKAITNRATLIVQKTNILQALAN-- 351

  Fly   485 AVSQLN-LNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSNG 548
            ::|.|| |:.:|.:....::.....|...|              ||......:..:...|..|:.
Mosquito   352 SISNLNSLSTNAMNSVGVSMVDHASPDAGG--------------GGGEAGGGDTEMVASTARSHS 402

  Fly   549 PNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAA 613
            |..   ||.:..|                            |..|:.:.|...   |.|:....:
Mosquito   403 PAF---GLENSSS----------------------------RYASSIVLETGM---PIGTPRAVS 433

  Fly   614 QEDFYSSRRQLYEERQSAEPRFISFQKEGS-VGIRLTGGNEA-GIFVTAVQPGSPASLQG-LMPG 675
            .||.            :..||.|..:|..| :|..:.||.:. ||||:.|..|..|.|.| |..|
Mosquito   434 SEDI------------TRVPRTIVIRKGASGLGFNIVGGEDGQGIFVSYVLAGGAADLGGELKRG 486

  Fly   676 DKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIVQYCKEEYDEV--------------------V 720
            |::|.||.:.:...:.|:|...|.:....:.|:|||..|:|:..                    .
Mosquito   487 DQLLSVNGISLANASHEDAAQALKNAGGTVTLVVQYRPEDYNRFEQRIQELKQAVAAGTGTLLRT 551

  Fly   721 TNQRGDSFHIKTHFHCDN------PSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQ 779
            |.:|  :.:::..|..|.      |::| :.|:.||:..|.:...:   ..||..::....:|..
Mosquito   552 TQKR--TLYVRALFDYDPNRDDGLPTRG-LQFRHGDILHVTNASDD---EWWQARRVIGEDEEES 610

  Fly   780 RGVIPNKSRAEELATAQFNATK---------------KEMNANESRGNFFRRRRSTHRRSKSLSR 829
            .|::|:|.|.|....|:..:.|               |....:..:.||...||....:||....
Mosquito   611 IGIVPSKRRWERKQRARDRSVKFQGHAGANNNNNNLEKVSTLDRKKKNFSFSRRFPFMKSKDDKN 675

  Fly   830 ENWDD-----------------------------------VV-------------------FSDS 840
            |:..|                                   ::                   ::||
Mosquito   676 EDGSDQEPNGNLSDPNHHDPDQPFMLCYTQEDANAEGGGEIIYRVELPDMEQITLIYLENNYADS 740

  Fly   841 ISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFST-------PLQD--------- 889
            .....:||.|......:.|||::.||:.|...:.|..::|:||.:       |.:|
Mosquito   741 EENILSYEPVQRLQISYTRPVIILGPLKDRINDDLISEYPNKFGSCVPHTTRPKRDYEVDGRDYH 805

  Fly   890 -----------------------DDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLN 931
                                   :|....||       ::::|:|.::|||.:||::.||:.||.
Mosquito   806 FIASREQMEKDIQNHLFIEAGQYNDNLYGTS-------VASVREVAEKGKHCILDVSGNAIKRLQ 863

  Fly   932 YAQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWY 996
            .||.||:.||:|..|...|.::..   :...:.:||..|:..|:|..:...|:..:.....|..|
Mosquito   864 VAQLYPIAIFIKPMSVESIMEMNR---RMTEEQAKKTYERTLKMEHEFGEYFTAIVQGDTIEEIY 925

  Fly   997 RKLRDSI 1003
            .|:::.|
Mosquito   926 SKVKNVI 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	35/86 (41%)
		PDZ_signaling	396..477	CDD:238492	17/90 (19%)
		PDZ_signaling	633..710	CDD:238492	27/79 (34%)
		SH3_ZO	729..790	CDD:212793	15/66 (23%)
		GuKc	831..1007	CDD:214504	51/266 (19%)
		ZU5	2263..2351	CDD:279170
AgaP_AGAP000255	XP_003436953.1	L27_1	4..62	CDD:286187
		PDZ_signaling	155..239	CDD:238492	35/85 (41%)
		PDZ_signaling	252..341	CDD:238492	23/130 (18%)
		PDZ_signaling	441..521	CDD:238492	27/79 (34%)
		SH3_DLG-like	558..618	CDD:212795	13/63 (21%)
		Guanylate_kin	757..935	CDD:279019	45/186 (24%)
		GuKc	765..935	CDD:214504	42/178 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910