DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pyd and AgaP_AGAP000452

DIOPT Version :9

Sequence 1:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster
Sequence 2:	XP_310641.4	Gene:	AgaP_AGAP000452 / 1271787	VectorBaseID:	AGAP000452	Length:	1168	Species:	Anopheles gambiae

Alignment Length:	889	Identity:	176/889 - (19%)
Similarity:	277/889 - (31%)	Gaps:	310/889 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   944 TDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALSDEESWYRKLRDSIDLQQS 1008
            |.|..|:....|..|.|......:|.:|.|:     .|::.||..|||.|
Mosquito   108 TASSPVLMPHCHHGPSAGGAQHHQLQQQQQQ-----QHVYGTQSILSDGE--------------- 152

  Fly  1009 GAVWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSDPSIA 1073
             .|...:.:|        .:|..|.    .:...|||.:..|...            ..:.|:..
Mosquito   153 -IVVFDDIEP--------NWPTGTG----GTVNGSDLSMLMGGGG------------GGTTPNKE 192

  Fly  1074 TNQDNLDRDRDIIGEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGVGGDTA 1138
            |:.|:..:.:.||| ||.   ...|:    .:|.|..|:.||.|:..||..|        ||
Mosquito   193 THTDSCTKIQTIIG-GLT---IAEYE----GSPRRFGTIYSSSYADGGTIRP--------GG--- 238

  Fly  1139 AVRPQSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRNGTLGRSAQERLFGKAVVQDDVQAEYI 1203
            |..|:       |..|.|::..:.|.|   .......|...||:...|..|..  ::.::.||.|
Mosquito   239 ASFPR-------PGFPKRVEPSAAPYD---QLDDGRPRQIELGKGPSETSFYN--IKSNMVAELI 291

  Fly  1204 TRNALVGSGAAETLDRQQQQQQQTHASLERQARLNAQLKANGVGAGGGGASTYDSVSSYDSYNNT 1268
            ....|:     ..||.....|:.|...|.:|..:..                  |:...:..:.|
Mosquito   292 LIPELI-----PILDDDDPIQELTLIPLPKQIAIPR------------------SIPIPEPISIT 333

  Fly  1269 Q--------------------------------------------------MAMQNLGRLGPNAP 1283
            :                                                  .|:::.....|:..
Mosquito   334 KPILIPKLIPILDPIPIPKPIPILDPILIPILDLFPILILDLIPKPIPIPITALESTLEWAPDQT 398

  Fly  1284 DDLKSVPNANGRP-LPPTGQSHEYGRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNID---- 1343
            .:.:|:|.:...| |.|..:| |.|            ::::...:..:  |:|...:.:::
Mosquito   399 PESESIPASETAPELIPNTES-ESG------------SEMSAFQTDTK--YYDRPQAGSLEEDFT 448

  Fly  1344 -PRNGTPQRPSNLGLESSPRKPLVETKTDYGKYSRNNSVTQADYTKLPKTAPHGVVPPPNVSNGQ 1407
             |.:||.::|.:..|  ||                     :.||.....||..|....| ||.|:
Mosquito   449 IPASGTGRKPHSFAL--SP---------------------EMDYRSGCGTAEFGTTFRP-VSYGR 489

  Fly  1408 GQMNGSGTPSSNGSGPFKPVPPPKPKNY------RPPVQSGGSSG----SGGTTPWENGDSGSPR 1462
            .|..|.|    ||:|..|.:.......|      .|.::.|.|||    |.|.|...:.|.|...
Mosquito   490 VQKPGGG----NGTGEAKEILNEPCVEYDDMCNSMPILEDGLSSGHASDSEGNTVANSCDQGGDL 550

  Fly  1463 SPNGFYYPPTPSHHHYGQQATPGSPSNGHMQPPPPQQQQPTYGGSNGNYGQAPPPQSYPQANGYN 1527
            ..||                :.|..|..|.|....||||..|
Mosquito   551 MANG----------------SLGMQSMRHQQDQQQQQQQQHY----------------------- 576

  Fly  1528 GNGHHY---NGGSGTGPYIAPHRGMPPPIGNLPPHTPERHALDLAGSREQRGSAFELYRKPQIGA 1589
               ||:   :|.:|.|........:...:.::........||....  |:|.||.:..|.
Mosquito   577 ---HHHAALDGPNGAGISDCLANDIRDALNDIKSTLQNTKALPTGD--ERRDSADQGCRG----- 631

  Fly  1590 TAGHHHNMSEMEPYDERYDDYYNM--------PPPAAHPSQGHHMQRSRSAPRYPHERPPHAQDP 1646
                       ||:...|.|...:        .|...|||..|...:     |:.:..||...:.
Mosquito   632 -----------EPFAHSYGDVSPVWVLRTRDGSPEQEHPSAAHLTDQ-----RHGNPPPPPDLEE 680

  Fly  1647 NYYGHYGTSR--GHSQPRQQYSQHHQQQYYD-DHGLEMGPPPLPPHKKKKSVLKSPLVALKNALL 1708
            .......|.|  ||.|  ||.|...:..||: ::..::|....|         |||..|:. |.|
Mosquito   681 ETDTDLETDRLLGHQQ--QQQSGGGEPSYYEHNNAADVGGVGKP---------KSPNSAML-AKL 733

  Fly  1709 KSTRPLRRMNSMVE----------PERKPKGLRR-QQSMLERGV 1741
            |..:...|.:|.:.          ||.:.||..: ::.:|:..|
Mosquito   734 KRYQTAIRADSEIYVPSDITLENLPEIESKGRHKTREGLLDPAV 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492
		PDZ_signaling	396..477	CDD:238492
		PDZ_signaling	633..710	CDD:238492
		SH3_ZO	729..790	CDD:212793
		GuKc	831..1007	CDD:214504	16/62 (26%)
		ZU5	2263..2351	CDD:279170
AgaP_AGAP000452	XP_310641.4	PTB_X11	775..953	CDD:269919	1/3 (33%)
		PDZ_signaling	986..1071	CDD:238492
		PDZ_signaling	1076..1149	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910