DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyd and Tjp2

DIOPT Version :9

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:XP_006231239.1 Gene:Tjp2 / 115769 RGDID:619807 Length:1193 Species:Rattus norvegicus


Alignment Length:1319 Identity:388/1319 - (29%)
Similarity:579/1319 - (43%) Gaps:357/1319 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 DRTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVN 306
            :...||.:||.:.:....|||||||||||||||.||:.||.:||||.||||:..||.|||::.||
  Rat    29 EEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVN 93

  Fly   307 GVSLENVEYATAVQVLRDSGNTVQLVVK--RRVPLNPINAAGAVQHQ------------------ 351
            |..:|:|.::.|||.||.||....:|||  |:|.:.|:..:..:.|.                  
  Rat    94 GTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEMMDEFDGRSFRSG 158

  Fly   352 -----------------------------------------------------HSHSLSSVGLMA 363
                                                                 .||..|....:.
  Rat   159 YSERSRHSSHDMLSHSWEDSRERGRPHQRAQSRERERSRGRSLERGLDHEDYGRSHERSRGRSLE 223

  Fly   364 NG------------------------------------SGGVAPT------PITSLSQPNS---L 383
            .|                                    .|..:|:      |.|...:..|   |
  Rat   224 RGLDRDFVSRDYSRGRSIDRDYDRDYERSYHQAYEPDYEGRYSPSYDRRAHPETRYERSRSREHL 288

  Fly   384 NS------SLVQNASSGQ-----PIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYS 437
            .|      |..:....||     ||.|.|||....::||:.||.::|:||::   |..|.....:
  Rat   289 RSRSPTPESRSRQEHKGQHDPDRPIGVLLTKSKANEEYGLRLGSQIFIKEMT---RTGLATKDGN 350

  Fly   438 LQEGDIITRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSAS------ 496
            |.|||||.:|:.| ..:.|||.:|:|:|:..:.:|.|||||| :.||.::..:||:|.|      
  Rat   351 LHEGDIILKINGT-VTENMSLTDARKLIEKSRGKLQLVVLRD-SKQTLINIPSLNDSDSEVEDIS 413

  Fly   497 --------------HQASGNIYATHQPQVSGCSSSNNNLEDPYLPGGASYSSQNLYVQPPTRTSN 547
                          .|.|...|.:...::....||...........||:          ||...:
  Rat   414 EIESNRSFSPEERRQQYSDQEYHSSTEKLKERPSSREETSGRMSRMGAT----------PTPFKS 468

  Fly   548 GPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGA 612
            ..:|...|:.:  :|..||.:...|:           |...|..|...     ||.|        
  Rat   469 TGDITAAGVTE--ANKEPRSQEESPV-----------PQPRTASRVFL-----RPSP-------- 507

  Fly   613 AQEDFYSSRRQLYEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDK 677
              ||         |.......:.:.|:|..|||:||.|||:.||||..:|.|:.|..:||..||:
  Rat   508 --ED---------EAIYGPNTKMVKFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQ 561

  Fly   678 ILKVNDMDMNGVTREEAVLFLLSLQ--DRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPS 740
            |||||..|..|:.||:|||:||.:.  :.:.::.|...:.|.:::...|||||.|::||.|:..:
  Rat   562 ILKVNTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKET 626

  Fly   741 KGEMAFKAGDVFRVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMN 805
            ...:||..|:||||:|||::|.:|.|..::||   .|:::|:||||||||::|:.| ||.::  |
  Rat   627 PQSLAFTRGEVFRVVDTLYDGKLGHWLAVRIG---NELEKGLIPNKSRAEQMASVQ-NAQRE--N 685

  Fly   806 ANESRGNFFRRR--RSTHRRSKSLSRENWDDVVFSDSIS-KFPAYERVVLRHPGFVRPVVLFGPV 867
            |.: |.:|:|.|  ||..:::...|||   |:..:.|:| ||||||:|:||..||.||||||||:
  Rat   686 AGD-RADFWRMRGQRSGVKKNIRKSRE---DLAAAVSVSTKFPAYEKVLLREAGFKRPVVLFGPI 746

  Fly   868 SDLARERLAKDFPDKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNY 932
            :|:|.|||..:.||.|.| .:.:.|.|.:.....:|||:.:|.::::.||||||:||.|||.|||
  Rat   747 ADIAMERLTTELPDLFQT-AKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNY 810

  Fly   933 AQFYPVVIFLKTDSKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIAL-SDEESWY 996
            .|::|:|||...||:..||.:|..|...::|||:||.:|..||::..||:|:..|.: |..:.|:
  Rat   811 TQWFPIVIFFNPDSRQGIKTIRQRLNPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWF 875

  Fly   997 RKLRDSIDLQQSGAVWMSESKPVESLSDD------FLFPMTTSRLSYASSPESDLELSPGPSASL 1055
            ..|:|||..||:.|||:||.| :|.:.||      :|..|....||..|...||.|.:.|...:.
  Rat   876 GSLKDSIQQQQNEAVWVSEGK-MEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAY 939

  Fly  1056 SLGNLPQ-----LVKA---SSDPSIATNQDNLDR-------------DRDIIGEGLPPPYTVPYD 1099
            :...|.:     ||.:   ||:|  ..:::::.:             .||.:.:|.|||...|..
  Rat   940 TDNELDEPAEEPLVSSITRSSEP--VQHEESIRKPSPEPRAQMRRAASRDQLRDGSPPPAFKPEP 1002

  Fly  1100 HAVPANPNRRQTMDSSKYSI---YGTNVPPQQQQPGVGGDT------AAVRPQSLYGINAPDLPP 1155
            ..| .|.||..:.:.||.::   .|:.:|        ||.|      .||:|.....|..|..| 
  Rat  1003 PKV-RNQNREDSFNYSKSNLSAMAGSEIP--------GGSTKGCPPPIAVKPAFGRSILKPSTP- 1057

  Fly  1156 RIDRQSKPGDIPLNTSGSSSRNGTLGRSAQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQ 1220
                      :|:..|..      :|.|.:|        |::.....:.|..:.     |.:|.:
  Rat  1058 ----------VPMPESEE------VGESTEE--------QEEAPKSVLGRVKIF-----EKMDHK 1093

  Fly  1221 QQQQQQTHASLERQARLNAQLKANGVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDD 1285
            .:.|:..    |.|...||::                           ::|.::         .|
  Rat  1094 AKLQRMQ----ELQEAQNARI---------------------------EIAQKH---------PD 1118

  Fly  1286 LKSVPNANGRPLPPTG-QSHEYGRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTP 1349
            :.:||..  .|.|..| ..|...|.|..            |.:|.| .|.|...|...||.....
  Rat  1119 IYAVPIK--APKPDAGLPQHMSSRPPEP------------QKAPSR-LYQDTRGSYGSDPEEEEE 1168

  Fly  1350 QRP-----SNLGLESSPRK 1363
            .|.     |..|..|.|.:
  Rat  1169 YRQQLAAHSKRGYYSQPSR 1187

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ_signaling 249..334 CDD:238492 47/84 (56%)
PDZ_signaling 396..477 CDD:238492 32/80 (40%)
PDZ_signaling 633..710 CDD:238492 35/78 (45%)
SH3_ZO 729..790 CDD:212793 27/60 (45%)
GuKc 831..1007 CDD:214504 80/177 (45%)
ZU5 2263..2351 CDD:279170
Tjp2XP_006231239.1 PDZ_signaling 36..121 CDD:238492 47/84 (56%)
DUF1777 212..>312 CDD:285811 14/99 (14%)
PDZ 315..392 CDD:214570 34/81 (42%)
PDZ_signaling 517..594 CDD:238492 35/76 (46%)
SH3_ZO-2 611..673 CDD:212960 31/64 (48%)
GuKc 707..886 CDD:214504 83/182 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166348853
Domainoid 1 1.000 113 1.000 Domainoid score I5991
eggNOG 1 0.900 - - E1_KOG3580
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1175136at2759
OrthoFinder 1 1.000 - - FOG0001438
OrthoInspector 1 1.000 - - otm44449
orthoMCL 1 0.900 - - OOG6_103390
Panther 1 1.100 - - O PTHR13865
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1692
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.750

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